Protein Alignment Tmtc1 and Dnaaf4

DIOPT Version :10

• Sequence 1: NP_995615.2
• Gene: Tmtc1 / 33455
• FlyBaseID: FBgn0051690
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_080590.3
• Gene: Dnaaf4 / 67685
• MGIID: 1914935
• Length: 420
• Species: Mus musculus
• Alignment Length: 316
• Identity: 59/316 - (18%)
• Similarity: 114/316 - (36%)
• Gaps: 82/316 - (25%)

  Fly     9 EKKMFHPNVKRYIQAIKLYNESIAFSEKGSTERALAYVNRSNICLKMQRFEECLENIRLARESNY 73
            ||..:...:::.|.|.         ::.|||:.            ...||......:||:.:.:.
Mouse  1060 EKNTWKDQLEKTISAA---------AQGGSTKP------------NTPRFRSPGAGVRLSADQSE 1103

  Fly    74 PGEKLIQREKEVKNALAKARNKNASSSKASPDVVEEPELSYAAKENAPQVANCLELRKNEEYGRH 138
            ..|..:..::|.:..|:..... |.:::..||  |:|:   ..::|...||        |...:.
Mouse  1104 GSESRMYPDREDEMVLSPVVTP-ADAAEECPD--EDPD---PGQKNKAGVA--------ESALQD 1154

  Fly   139 VVTTRKLKVGDVVMIERPFVTVLKDSFRYVRCD-----FCHEERPFTLIPCEGCTMAMYCSEECL 198
            |.|.|:|...|           |:|.:.....|     ..:|..|||..|      ....|:...
Mouse  1155 VETLRQLIFRD-----------LEDGWSQDSDDTPTNETANERSPFTDRP------GNESSDPAP 1202

  Fly   199 SKAYNNYHRYECGLLRDLWEVFEAVPL----IAIRMIAIAIATFDNNPEALKDHLDALDESNVNG 259
            |::.:.:..          |..||.||    .|::::..|:....:.|:.:.|.:.|...|...|
Mouse  1203 SESSSQWEE----------EPVEAPPLEVLQPAVQVVRKAVGVGCSLPDDITDDVTASQSSEDGG 1257

  Fly   260 FTMDWNKATQQDIFNTVHVLTTNQERRDSFFVAFYIFNATILHTLVLERTELEPVC 315
            .......:|.|.:.:.    :|..|.:|   :...:|:::.::    |..|.:..|
Mouse  1258 NLFYLVMSTDQVVSDE----STTDELKD---LHHSVFSSSFIN----EEEEQDTPC 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc1	NP_995615.2	ArnT	11..>209	CDD:441412	36/202 (18%)
		TMTC_DUF1736	271..340	CDD:462468	7/45 (16%)
		PilF	501..585	CDD:442297
		TPR repeat	518..546	CDD:276809
		TPR repeat	551..581	CDD:276809
		LapB	556..838	CDD:442196
		TPR repeat	586..611	CDD:276809
		TPR repeat	634..660	CDD:276809
		TPR repeat	671..699	CDD:276809
		TPR repeat	704..735	CDD:276809
		TPR repeat	740..768	CDD:276809
		TPR repeat	773..803	CDD:276809
		TPR repeat	808..836	CDD:276809
Dnaaf4	NP_080590.3	Mediates interaction with ESR1 and STUB1. /evidence=ECO:0000250	7..103
		p23_DYX1C1_like	10..87	CDD:107226
		PTZ00121	<106..>270	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	164..212
		3a0801s09	250..>394	CDD:273380
		TPR 1	288..321
		TPR repeat	288..316	CDD:276809
		TPR repeat	321..351	CDD:276809
		TPR 2	322..355
		TPR repeat	362..392	CDD:276809
		TPR 3	364..397