DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and FKBPL

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_071393.2	Gene:	FKBPL / 63943	HGNCID:	13949	Length:	349	Species:	Homo sapiens

Alignment Length:	296	Identity:	71/296 - (23%)
Similarity:	101/296 - (34%)	Gaps:	96/296 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 LPASNL------LFYVGFVMAERVLYLPSVGYC---LLFGLGFGHLWQRVNSSWRSRLMLLCGLA 485
            |.||:|      .|....|:....|..|.:|.|   |..|..||   ......|..
Human    91 LQASDLWYCPDGSFVKKIVIRGHGLDKPKLGSCCRVLALGFPFG---SGPPEGWTE--------- 143

  Fly   486 LLLGVHGVRTFRRNLDWRDEE--QLFRSAISINPPKALGNLGSVLSAQGRYEEAELTL------- 541
            |.:||.         .||:|.  :|..        |.|.::     .||  |||||.|
Human   144 LTMGVG---------PWREETWGELIE--------KCLESM-----CQG--EEAELQLPGHSGPP 184

  Fly   542 -RMTLGHRPTMADAHFNLGVVHQKQL---------------NFSSAIPCFRRAIEL--------R 582
             |:||.......|: :.|....::.|               |...|..|:.||:.|        .
Human   185 VRLTLASFTQGRDS-WELETSEKEALAREERARGTELFRAGNPEGAARCYGRALRLLLTLPPPGP 248

  Fly   583 PQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGR 647
            |:..|.:.||....:.||..:..|.|..|...|..|        |::|.|    :..|...:.|.
Human   249 PERTVLHANLAACQLLLGQPQLAAQSCDRVLEREPG--------HLKALY----RRGVAQAALGN 301

  Fly   648 LQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAE 683
            |:.|.|.|::.|...|    |.||... .||:::.:
Human   302 LEKATADLKKVLAIDP----KNRAAQE-ELGKVVIQ 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	22/95 (23%)
		TPR repeat	518..546	CDD:276809	12/35 (34%)
		TPR repeat	551..581	CDD:276809	8/44 (18%)
		TPR_1	552..584	CDD:278916	9/54 (17%)
		TPR	565..841	CDD:223533	34/142 (24%)
		TPR repeat	586..611	CDD:276809	7/24 (29%)
		TPR repeat	634..660	CDD:276809	6/25 (24%)
		TPR repeat	671..699	CDD:276809	3/13 (23%)
		TPR repeat	704..735	CDD:276809
		TPR repeat	740..768	CDD:276809
		TPR repeat	773..803	CDD:276809
		TPR	808..841	CDD:197478
		TPR repeat	808..836	CDD:276809
FKBPL	NP_071393.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..55
		TPR_11	187..>348	CDD:330823	38/164 (23%)
		TPR 1	210..243		6/32 (19%)
		TPR repeat	210..238	CDD:276809	5/27 (19%)
		TPR repeat	251..281	CDD:276809	8/29 (28%)
		TPR 2	252..285		10/40 (25%)
		TPR 3	286..319		10/40 (25%)
		TPR repeat	286..314	CDD:276809	8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900