DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc1 and BBS4

DIOPT Version :10

Sequence 1:NP_995615.2 Gene:Tmtc1 / 33455 FlyBaseID:FBgn0051690 Length:859 Species:Drosophila melanogaster
Sequence 2:NP_149017.2 Gene:BBS4 / 585 HGNCID:969 Length:519 Species:Homo sapiens


Alignment Length:472 Identity:96/472 - (20%)
Similarity:165/472 - (34%) Gaps:141/472 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   368 LLRRLGGN---------SCHTWLGLTCDCHHQLSAP-----SYRSASAIYSTSSKSKSASWTAAP 418
            |:.||.||         :|......:.|...|::..     .:::|..:|:.::|.....|..:.
Human    75 LIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISH 139

  Fly   419 ILGTAFLVL-PFLPASNLLFY--------VGFVMAERV------------LYLPSVGYC-----L 457
            .||..::.| .|..|.:.|..        :.::|..::            :|..:|.:.     |
Human   140 NLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTEL 204

  Fly   458 LFGLG------------FGHLWQRVN-SSWRSRLMLLCGLALLLGVHG-----VRTFRRNLDWRD 504
            |..||            |.||...:. .....:.:|..|  .::..||     :..:|       
Human   205 LTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAG--SMMQTHGDFDVALTKYR------- 260

  Fly   505 EEQLFRSAISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFS 569
               :...|:..:|| ...|:|.....:.:|..|...|:......|......:|||:||.....::
Human   261 ---VVACAVPESPP-LWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYA 321

  Fly   570 SAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARY-- 632
            ||......||..:|::...|:.|..:|.:|.|              :|.:    :.|:.||.:  
Human   322 SAFHFLSAAINFQPKMGELYMLLAVALTNLED--------------IENA----KRAYAEAVHLD 368

  Fly   633 TC----YLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEHQ 693
            .|    .|..:||..:.|..::|.|..:|..|.:.||  |..:.|..          |....|..
Human   369 KCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLL--KDNSSLEF----------DSEMVEMA 421

  Fly   694 QRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQLAPL-EPSSHHHY------ADFLE 751
            |:|...||                    :.||..|.|      |: :|.|.|..      |.| :
Human   422 QKLGAALQ--------------------VGEALVWTK------PVKDPKSKHQTTSTSKPASF-Q 459

  Fly   752 QQERHHEALGLRLRAAA 768
            |....::|||..:.:||
Human   460 QPLGSNQALGQAMSSAA 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc1NP_995615.2 ArnT 11..>209 CDD:441412
TMTC_DUF1736 271..340 CDD:462468
PilF 501..585 CDD:442297 19/83 (23%)
TPR repeat 518..546 CDD:276809 6/27 (22%)
TPR repeat 551..581 CDD:276809 9/29 (31%)
LapB 556..838 CDD:442196 54/226 (24%)
TPR repeat 586..611 CDD:276809 5/24 (21%)
TPR repeat 634..660 CDD:276809 8/29 (28%)
TPR repeat 671..699 CDD:276809 5/27 (19%)
TPR repeat 704..735 CDD:276809 4/30 (13%)
TPR repeat 740..768 CDD:276809 9/33 (27%)
TPR repeat 773..803 CDD:276809
TPR repeat 808..836 CDD:276809
BBS4NP_149017.2 Required for localization to centrosomes 1..66
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
TPR repeat 36..61 CDD:276809
TPR 1 67..100 6/24 (25%)
TPR repeat 68..95 CDD:276809 6/19 (32%)
LapB 71..332 CDD:442196 50/269 (19%)
Interaction with PCM1. /evidence=ECO:0000269|PubMed:15107855 101..337 46/248 (19%)
TPR repeat 101..129 CDD:276809 4/27 (15%)
TPR repeat 134..164 CDD:276809 7/29 (24%)
TPR repeat 169..196 CDD:276809 2/26 (8%)
TPR repeat 202..229 CDD:276809 7/26 (27%)
TPR repeat 236..264 CDD:276809 5/39 (13%)
Spy 250..>446 CDD:443119 55/262 (21%)
TPR repeat 270..298 CDD:276809 7/28 (25%)
TPR repeat 303..333 CDD:276809 9/29 (31%)
Required for localization to centrosomes 338..519 44/196 (22%)
TPR repeat 338..365 CDD:276809 8/44 (18%)
TPR repeat 372..397 CDD:276809 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..519 11/38 (29%)
Blue background indicates that the domain is not in the aligned region.

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