DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and kdm6al

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_005168853.1	Gene:	kdm6al / 569207	ZFINID:	ZDB-GENE-070112-2002	Length:	1356	Species:	Danio rerio

Alignment Length:	799	Identity:	149/799 - (18%)
Similarity:	247/799 - (30%)	Gaps:	276/799 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 PSRMGVLAAGA--LFAVHPAHTEAVAGLVGRAD-------------LASCVCYLLAYLSYRRHML 179
            |.|:.|.||.|  |.|......:..||.....:             ||.....|..|  .|.|
Zfish     3 PCRVSVAAAAARRLSAAGDEEKKMAAGKASEPEEESPRLSAQESDTLARVDSSLFGY--QRLH-- 63

  Fly   180 NREWGSLILTIMLALAALLCKETAITALLLCGLCDVLSPVGRENSDKVCDGSISGLASFNFQRRF 244
              |.|:.:..::  :.|:.|.|:.|           |...|:.:.:..|.     |..||.
Zfish    64 --EDGASMKALL--VKAVRCYESLI-----------LKAEGKVDPEFFCQ-----LGHFNL---- 104

  Fly   245 RSLSILGFTLLCGLYCRLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQEL 309
                               ||.....|.||.....:.:|.:| :...|||    ..|::.:...
Zfish   105 -------------------LLEEYPKALSAYQRYYSLQSDYW-KNAAFLY----GLGMVYFHYN- 144

  Fly   310 SFDWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLG- 373
            :|.|.::|...                     :|:...|         |:....|.|    |||
Zfish   145 AFQWAIKAFQE---------------------VLYIDPG---------FSRAKEIHL----RLGL 175

  Fly   374 ---------GNSCHTWLGLTCDCHHQLSAPSYRSASA-IYSTSSKSKSASWTAAPILGTAFLVLP 428
                     .:..|..|.|.......||....:...| :|....:.::|......:|.|..|..|
Zfish   176 MFKVNTDYESSLKHFQLALIDSSRCTLSKAEIQFHIAHLYEIQKRHRAAKEAYESLLQTEDLQTP 240

  Fly   429 FLPASNLLFYVGFVMAERVLYLPSVGYCLLFGLGFGH-----LWQRVNSSWRSRLMLLCGLALLL 488
            ...|:                        |..||:.|     |..:.|..
Zfish   241 VRAAA------------------------LQQLGWMHHTVEQLGDKANKD--------------- 266

  Fly   489 GVHGVRTFRRNLDWRDEEQLFRSAISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMAD 553
             .:.::..:::|:           ...|..::...||...|:.|:.::|.::.|.::......||
Zfish   267 -SYAIQCLQKSLE-----------ADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASAD 319

  Fly   554 AHFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLG---DHRQEAISVLRTGAR 615
            ...::||::|:|.....|:..:..|::|....|.|:::|||...|..   |..:..|:..|:...
Zfish   320 TWCSIGVLYQQQNQPMDALQAYICAVQLDHSHAAAWMDLGTLYESCNQPHDAIKCYINATRSKTC 384

  Fly   616 LEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEI 680
            ...:.:..|..:::|:: |.|:|:              :|:...|.||.:.:....       .|
Zfish   385 SNTAALAARIKYLQAQF-CKLRLN--------------SLQGKSKTLPNIEEAWSL-------PI 427

  Fly   681 LAELQDWNEAEHQQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEA---ESWFKRALQLAPLEPSS 742
            .|||......:.....|.:.||...:........|..:.:.|..|   .|..:|....:|.:.|:
Zfish   428 PAELTSRQGVQSTGPQACKAQPGASSGSQASAPALPPHSTALEPAGAQTSPARRRRSSSPAQSST 492

  Fly   743 H------------HHY-----ADFLEQQERHHEALGLRLRAAALAPQDYTLQSCVADALRLLNRL 790
            .            |.|     ...|||         ||...|:|.|..          |::|.::
Zfish   493 DSWSSGSAHTPVPHWYLTPQKLQLLEQ---------LRASRASLKPAQ----------LQMLEQM 538

  Fly   791 AEAELWYRKAVTLQPMAAHAHANLGAILQMR------------------GLRKEAVACYHKALEL 837
             ||:|          .|.|.|..     |||                  ..|..|:...|.....
Zfish   539 -EAQL----------SAMHLHQQ-----QMRQNSSGQIRPSLSNGPSLPASRGPALQTLHNGPGP 587

  Fly   838 QPG---------HAISRAN 847
            :||         |..||||
Zfish   588 RPGPQTPAVRNNHTESRAN 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	11/67 (16%)
		TPR_11	518..583	CDD:290150	15/64 (23%)
		TPR repeat	518..546	CDD:276809	6/27 (22%)
		TPR repeat	551..581	CDD:276809	8/29 (28%)
		TPR_1	552..584	CDD:278916	9/31 (29%)
		TPR	565..841	CDD:223533	62/325 (19%)
		TPR repeat	586..611	CDD:276809	8/27 (30%)
		TPR repeat	634..660	CDD:276809	4/25 (16%)
		TPR repeat	671..699	CDD:276809	5/27 (19%)
		TPR repeat	704..735	CDD:276809	5/33 (15%)
		TPR repeat	740..768	CDD:276809	8/44 (18%)
		TPR repeat	773..803	CDD:276809	5/29 (17%)
		TPR	808..841	CDD:197478	10/59 (17%)
		TPR repeat	808..836	CDD:276809	8/45 (18%)
kdm6al	XP_005168853.1	TPR_11	92..161	CDD:290150	19/123 (15%)
		TPR repeat	93..121	CDD:276809	9/55 (16%)
		TPR_11	129..194	CDD:290150	17/103 (17%)
		TPR repeat	129..159	CDD:276809	8/55 (15%)
		TPR_1	130..163	CDD:278916	9/67 (13%)
		TPR repeat	164..194	CDD:276809	7/33 (21%)
		TPR repeat	205..233	CDD:276809	3/27 (11%)
		TPR repeat	243..278	CDD:276809	7/74 (9%)
		TPR_17	272..303	CDD:290167	6/41 (15%)
		TPR_11	285..348	CDD:290150	14/62 (23%)
		TPR repeat	285..312	CDD:276809	6/26 (23%)
		TPR repeat	317..347	CDD:276809	8/29 (28%)
		TPR_1	318..351	CDD:278916	9/32 (28%)
		TPR repeat	352..378	CDD:276809	8/25 (32%)
		JmjC	1053..1117	CDD:214721
		JmjC	1087..1195	CDD:202224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900