DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and tmtc2a

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001124075.1	Gene:	tmtc2a / 564667	ZFINID:	ZDB-GENE-041210-299	Length:	844	Species:	Danio rerio

Alignment Length:	855	Identity:	329/855 - (38%)
Similarity:	463/855 - (54%)	Gaps:	60/855 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CSALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVL 90
            |||:|.:||:|||:|.|.|||.|||..|.|:....|..|:|.:|||||.|..||||.|:||||.:
Zfish     7 CSAVALLLYMNTLSADFCYDDSRAIKTNQDLLPDTPWTNILYDDFWGTLLTHSGSHKSFRPLCTI 71

  Fly    91 SFRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLPSRMGVLAAGALFAVHPAHTEAVAGL 155
            ||||||..||:.|.|:||.||.|||..|.|.....|.||......|.||.|||.||.|||||||:
Zfish    72 SFRLNYFLGGLDPYGFHLFNVGLHCCVTALFTAFCRPLLGGGPWSLLAGLLFASHPIHTEAVAGV 136

  Fly   156 VGRADLASCVCYLLAYLSYRR---------HMLNREW--GS-LILTIMLALAALLCKETAITALL 208
            |||||:.:..|:||:.|.|.:         |.....|  || |..::..|.||||.||..:|.|.
Zfish   137 VGRADVGAAFCFLLSLLCYSQYCRLRHNAAHSSRVAWRAGSWLAGSLGAAAAALLWKEQGVTVLA 201

  Fly   209 LCGLCDVLSPVGRENSDKVCDGSISGLASFNFQRRFRSLSILGFTLLCG-----LYCRLSLLPRP 268
            :..:.|| ..|.|..        :........:|:.||| ::....|.|     |..|...:...
Zfish   202 VSAVYDV-CVVHRLR--------LRQALIVLLKRKNRSL-LVSLAWLVGWGIILLTARFHWMGNK 256

  Fly   269 STAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARNILTA 333
            ...||.:|||.|....|.||.|||||||..|..:||.|.:|||||.|:||..::::.|.||:.:.
Zfish   257 PPNFSNSDNPAADSPHFLTRALTFLYLPSVNAWLLLCPDKLSFDWSMDAVPLLKSIADWRNLQSV 321

  Fly   334 GFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLG--LTCDCHHQLSAPSY 396
            .||.....:.|  ..||:  .|:...::        ....|.| |...|  .|..|.|:.:...|
Zfish   322 MFYSGFALLAW--FSLRN--PPLQATKI--------NESNGKS-HVSNGKYATNGCSHKHNDNHY 373

  Fly   397 RSASAIYSTS--SKSKSASWTAAP------ILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPSV 453
            |..: :.|..  :||...|....|      :.....|||||:||:||.||||||:||||||:||:
Zfish   374 RDLN-LKSNGYHNKSLKVSQKTLPATESVVVFSLGLLVLPFIPATNLFFYVGFVVAERVLYIPSM 437

  Fly   454 GYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINPP 518
            |:|||...|...|:.|..|.....|:|.|...|:| ::.::|.|||.||:.||.|:||.|::||.
Zfish   438 GFCLLVTAGVRSLFVRCRSKSFRALLLTCTAGLVL-LYSLKTVRRNQDWKSEEMLYRSGIAVNPA 501

  Fly   519 KALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRP 583
            ||.||||:||..||:..|||...|..|.:|..|||..:|||::.|:...||.|:..::.||..||
Zfish   502 KAWGNLGNVLKNQGKMAEAERAYRNALYYRGNMADMLYNLGLLLQENERFSEALHYYKLAIGSRP 566

  Fly   584 QLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRL 648
            .||.||||:|..|:|.| :.:||.....|.|.:....::|..||..:..:|...|..|....|:.
Zfish   567 TLASAYLNVGIILVSQG-NIEEAKRTFHTCADIPDENLKDPHAHKSSVTSCLYNLGKLLHDQGQH 630

  Fly   649 QDAAAALRESLKALP--LLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVTY 711
            ::|.:..:|:::.:|  ..||.    |:..:||....|....||.|..|.:::.:|:...|::||
Zfish   631 EEALSVYKEAVRKMPRQFAPQS----LYNMMGEAYMRLNILEEAGHWYRESLKAKPDHIPAHLTY 691

  Fly   712 GQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDYTL 776
            |:.|:..|.: :|||.:|.:|::|.|...:.:.||..||.::.|..||..:..:||.|..:::.:
Zfish   692 GKLLSIMGQK-SEAERYFLKAIELDPARGNCYMHYGQFLLEESRLAEAAAMAQKAAELDNEEFDV 755

  Fly   777 QSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQPGH 841
            ....|..||..:...|||.:|.||..|:|....|..||||||.:.|..|||.:.|.:||:|:|..
Zfish   756 VFSAAHMLRQASLNEEAETYYGKAADLRPDHPAALMNLGAILHLNGKLKEAESNYLRALQLKPDD 820

  Fly   842 AISRANLARM 851
            .|:::||.::
Zfish   821 LITQSNLHKL 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	33/67 (49%)
		TPR_11	518..583	CDD:290150	28/64 (44%)
		TPR repeat	518..546	CDD:276809	14/27 (52%)
		TPR repeat	551..581	CDD:276809	12/29 (41%)
		TPR_1	552..584	CDD:278916	12/31 (39%)
		TPR	565..841	CDD:223533	92/277 (33%)
		TPR repeat	586..611	CDD:276809	11/24 (46%)
		TPR repeat	634..660	CDD:276809	6/25 (24%)
		TPR repeat	671..699	CDD:276809	8/27 (30%)
		TPR repeat	704..735	CDD:276809	11/30 (37%)
		TPR repeat	740..768	CDD:276809	8/27 (30%)
		TPR repeat	773..803	CDD:276809	9/29 (31%)
		TPR	808..841	CDD:197478	16/32 (50%)
		TPR repeat	808..836	CDD:276809	13/27 (48%)
tmtc2a	NP_001124075.1	DUF1736	254..328	CDD:285594	33/73 (45%)
		TPR_11	501..562	CDD:290150	26/60 (43%)
		TPR repeat	501..529	CDD:276809	14/27 (52%)
		TPR_1	501..>528	CDD:278916	14/26 (54%)
		TPR repeat	534..564	CDD:276809	12/29 (41%)
		TPR_1	535..>562	CDD:278916	9/26 (35%)
		TPR_12	565..642	CDD:290160	25/77 (32%)
		TPR repeat	569..597	CDD:276809	12/28 (43%)
		TPR repeat	603..642	CDD:276809	9/38 (24%)
		TPR_2	617..646	CDD:285020	5/28 (18%)
		TPR_11	653..716	CDD:290150	21/63 (33%)
		TPR repeat	653..679	CDD:276809	8/25 (32%)
		TPR repeat	684..714	CDD:276809	11/30 (37%)
		TPR_8	685..716	CDD:289924	12/31 (39%)
		TPR_16	757..820	CDD:290168	27/62 (44%)
		TPR_1	787..820	CDD:278916	16/32 (50%)
		TPR repeat	787..815	CDD:276809	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	197	1.000	Domainoid score	I3060
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1414
OMA	1	1.010	-	-		QHG52430
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0004694
OrthoInspector	1	1.000	-	-		mtm6573
orthoMCL	1	0.900	-	-		OOG6_106232
Panther	1	1.100	-	-	O	PTHR44216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3302
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840