DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and tmtc2b

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_021323440.1	Gene:	tmtc2b / 555381	ZFINID:	ZDB-GENE-081031-100	Length:	837	Species:	Danio rerio

Alignment Length:	857	Identity:	331/857 - (38%)
Similarity:	467/857 - (54%)	Gaps:	71/857 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CSALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVL 90
            |||:|.:||:|||:|.|.|||.|||..|.|:....|..|:..:|||||.|..||||.|:||||.|
Zfish     7 CSAVALLLYVNTLDADFCYDDSRAIKTNQDLFPETPWINIFYDDFWGTLLTHSGSHKSYRPLCTL 71

  Fly    91 SFRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLPSRMGVLAAGALFAVHPAHTEAVAGL 155
            ||||||..||:.|.|||||||:|||.||.|...::..||.|....|.||.|||.||.|||||||:
Zfish    72 SFRLNYALGGLDPWGYHLVNVVLHCTATGLFSSLSSLLLGSGCWSLLAGLLFAAHPIHTEAVAGI 136

  Fly   156 VGRADLASCVCYLLAYLSYRRHMLNR-------EWGSLILTIMLALAALLCKETAITALLLCGLC 213
            |||||:.:.:.||||...|..|...|       .|...:.|:..|..::|.||..:|.|.:..:.
Zfish   137 VGRADVGAALFYLLALRCYICHCTLRTSSAHGWSWMWFLGTLGCASCSMLWKEQGVTVLAVAAIY 201

  Fly   214 DV-------LSPVGRENSDKVCDGSISGLASFNFQRRFR---SLSILGFTLLCGLYCRLSLLPRP 268
            ||       |..|.               |.|..::..|   |:.:|||..:..|.|||..:...
Zfish   202 DVFVFHKLKLQQVP---------------ALFQKKKNLRLLLSVFLLGFWGVILLACRLYWMGNK 251

  Fly   269 STAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARNILTA 333
            ...||.:|||.|...||.|||||||:||..|..:||.|..|||||.|:|:..:|::.|.||:.|.
Zfish   252 PPNFSNSDNPAADCPCFLTRTLTFLFLPAINVWLLLCPDMLSFDWSMDALPLLRSIADWRNLHTV 316

  Fly   334 GFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQLSAPSYRS 398
            .||.||:::.|.|..|....|               :...|.:.|...|.:.:.|   |..:...
Zfish   317 AFYTSLLSLAWFGLHLYPTKS---------------KETNGKAHHVANGKSSNGH---SCSTDYE 363

  Fly   399 ASAIYSTSSKSKSASWT------------AAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLP 451
            .|..||.|.:....:.|            :..:.....|.:||:||:||.||||||:||||||:|
Zfish   364 NSTFYSNSVQMNGTNGTVKHYSSSLPTTESLVVFSLGLLAIPFIPATNLFFYVGFVVAERVLYIP 428

  Fly   452 SVGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISIN 516
            |:|||||..||...|:.|:.......|:|.|..||:| :.|::|..||.||::||.|::|.||:|
Zfish   429 SMGYCLLVALGMRCLYVRLRRKSSRTLVLGCSAALVL-LFGIKTVLRNRDWQNEEMLYKSGISVN 492

  Fly   517 PPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIEL 581
            |.||.||||:||..||:.||||...|..|.:|..|||..:|||::.|:...||.|:..::.||..
Zfish   493 PAKAWGNLGNVLKNQGKVEEAEQAYRNALYYRRNMADMLYNLGLLLQENSRFSEALHYYKLAIGS 557

  Fly   582 RPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDG 646
            ||.||.||||.|..|::.| ..:||.....|.|.:....::|..||..:..:|...|..|....|
Zfish   558 RPTLASAYLNTGIVLMNQG-RLEEAKRTFVTCAEISDENLKDPHAHKSSVTSCLYNLGKLLHEQG 621

  Fly   647 RLQDAAAALRESLKALP--LLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYV 709
            ..::|.:..:|:::.:|  ..||.    |:..:||....|....||||..:.:::.:|:...|::
Zfish   622 HQEEAISVYKEAIQKMPRQFAPQS----LYNMMGEAFMRLNKLTEAEHWYKESLRAKPDHIPAHL 682

  Fly   710 TYGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDY 774
            |||:.||..|.: .|||.:|.:|::|.|.:.:.:.||..||.::.|..||..:..:||.|..:::
Zfish   683 TYGKLLAMTGQK-TEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLLEAAEMAEKAAQLDTEEF 746

  Fly   775 TLQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQP 839
            .:....|..||..:....||.:||:|.:|:|....|..||||||.:.|..:||.|.|.:||:|:|
Zfish   747 DVVFSAAHMLRQASLNDAAEKYYRQAASLRPNYPAALMNLGAILHLNGKLQEAEANYLRALQLKP 811

  Fly   840 GHAISRANLARM 851
            ...|:::||.::
Zfish   812 DDTITQSNLRKL 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	36/67 (54%)
		TPR_11	518..583	CDD:290150	29/64 (45%)
		TPR repeat	518..546	CDD:276809	15/27 (56%)
		TPR repeat	551..581	CDD:276809	12/29 (41%)
		TPR_1	552..584	CDD:278916	12/31 (39%)
		TPR	565..841	CDD:223533	91/277 (33%)
		TPR repeat	586..611	CDD:276809	10/24 (42%)
		TPR repeat	634..660	CDD:276809	6/25 (24%)
		TPR repeat	671..699	CDD:276809	8/27 (30%)
		TPR repeat	704..735	CDD:276809	12/30 (40%)
		TPR repeat	740..768	CDD:276809	8/27 (30%)
		TPR repeat	773..803	CDD:276809	8/29 (28%)
		TPR	808..841	CDD:197478	16/32 (50%)
		TPR repeat	808..836	CDD:276809	13/27 (48%)
tmtc2b	XP_021323440.1	DUF1736	250..323	CDD:312047	36/72 (50%)
		TPR	482..713	CDD:223533	86/236 (36%)
		TPR repeat	494..522	CDD:276809	15/27 (56%)
		TPR repeat	527..557	CDD:276809	12/29 (41%)
		TPR repeat	562..585	CDD:276809	10/23 (43%)
		TPR repeat	609..635	CDD:276809	6/25 (24%)
		TPR repeat	640..673	CDD:276809	10/36 (28%)
		TPR_11	<644..824	CDD:330823	63/185 (34%)
		TPR repeat	678..706	CDD:276809	12/28 (43%)
		TPR repeat	780..808	CDD:276809	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8878
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1414
OMA	1	1.010	-	-		QHG52430
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0004694
OrthoInspector	1	1.000	-	-		mtm6573
orthoMCL	1	0.900	-	-		OOG6_106232
Panther	1	1.100	-	-	O	PTHR44216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4791
SonicParanoid	1	1.000	-	-		X3302
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010