DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and bbs4

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001016280.1	Gene:	bbs4 / 549034	XenbaseID:	XB-GENE-952107	Length:	516	Species:	Xenopus tropicalis

Alignment Length:	467	Identity:	93/467 - (19%)
Similarity:	154/467 - (32%)	Gaps:	158/467 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 LPFLPASNLLFYVGFVMAERVLYLPSVGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGL------- 484
            ||.|...|.|.::.:|..:                     ::...:..:.:|....|:
Frog    26 LPILERRNWLIHLHYVRKD---------------------YESCKAVIKEQLQATQGVCEYAVYV 69

  Fly   485 -ALLLGVHGVRTFRRNLDWRDEEQLFRSAISINP---------PKALGNLGSVLSAQGRYEEA-- 537
             ||:|.:.|        ..::..:||::...:||         .::|..||...:|...|.||
Frog    70 QALILRLEG--------KIQESLELFQTCAVLNPTSSDNLKQVARSLFLLGKHKAAVEVYNEAAR 126

  Fly   538 ---------------------------ELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCF 575
                                       :|||.:.| ||..:  :...||.:..::.:...||..|
Frog   127 LNQKDWEICHNLGVCYLFLKDLSKSKEQLTLALQL-HRQDL--SAITLGKIQLQEGDIDGAIQTF 188

  Fly   576 RRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSV 640
            .:|::|.|:        .|.|::                                      .|.:
Frog   189 TQALQLSPE--------NTELLT--------------------------------------TLGL 207

  Fly   641 LYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQG 705
            ||..:|..|.|...|.   .||...|...:.:  |..|.::....|::.|..:.|:|....||..
Frog   208 LYLQNGLFQKAFEYLG---NALTYDPSNYKGI--LAAGCMMQSHGDYDVALSKYRVAASSVPESS 267

  Fly   706 AAYVTYGQTLARNGSRLAEAESWFKRALQLAP----------LEPSSHHHYAD---FLEQQ-ERH 756
            ..:...|.........:| |.|..||||.|:|          |...|...||.   ||... ..|
Frog   268 PLWNNIGMCFYGKKKYVA-AISCLKRALYLSPFDWRVLYNLGLVHLSMQQYASAFHFLSAAISLH 331

  Fly   757 HEALGLRLRAAALAPQDYTLQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMR 821
            |...||           |.|   :|.||..|:.:..|:..|::|.:|.......:.|...:|..:
Frog   332 HGNAGL-----------YML---LAVALTYLDDIENAKSSYQQAASLDQTDPLVNLNFAVLLYNQ 382

  Fly   822 GLRKEAVACYHK 833
            |.:|.|:..|.:
Frog   383 GDKKGALGQYQE 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	20/93 (22%)
		TPR repeat	518..546	CDD:276809	10/56 (18%)
		TPR repeat	551..581	CDD:276809	6/29 (21%)
		TPR_1	552..584	CDD:278916	7/31 (23%)
		TPR	565..841	CDD:223533	62/283 (22%)
		TPR repeat	586..611	CDD:276809	2/24 (8%)
		TPR repeat	634..660	CDD:276809	7/25 (28%)
		TPR repeat	671..699	CDD:276809	6/27 (22%)
		TPR repeat	704..735	CDD:276809	8/30 (27%)
		TPR repeat	740..768	CDD:276809	9/31 (29%)
		TPR repeat	773..803	CDD:276809	9/29 (31%)
		TPR	808..841	CDD:197478	6/26 (23%)
		TPR repeat	808..836	CDD:276809	6/26 (23%)
bbs4	NP_001016280.1	TPR 1	64..97		8/40 (20%)
		TPR repeat	65..92	CDD:276809	6/34 (18%)
		PEP_TPR_lipo	<66..398	CDD:274350	85/406 (21%)
		TPR 2	98..131		7/32 (22%)
		TPR repeat	101..126	CDD:276809	7/24 (29%)
		TPR repeat	131..161	CDD:276809	3/29 (10%)
		TPR 3	133..165		6/32 (19%)
		TPR 4	166..198		8/41 (20%)
		TPR repeat	166..193	CDD:276809	6/28 (21%)
		TPR repeat	199..226	CDD:276809	9/67 (13%)
		TPR 5	200..232		11/72 (15%)
		TPR 6	234..266		7/33 (21%)
		TPR repeat	237..261	CDD:276809	6/23 (26%)
		TPR 7	267..300		10/33 (30%)
		TPR repeat	269..295	CDD:276809	7/26 (27%)
		TPR repeat	300..330	CDD:276809	6/29 (21%)
		TPR 8	302..334		8/31 (26%)
		TPR repeat	335..361	CDD:276809	10/39 (26%)
		TPR 9	336..368		12/45 (27%)
		TPR repeat	369..394	CDD:276809	6/24 (25%)
		TPR 10	370..402		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..516
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910