DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and IFIT1B

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001010987.1	Gene:	IFIT1B / 439996	HGNCID:	23442	Length:	474	Species:	Homo sapiens

Alignment Length:	445	Identity:	91/445 - (20%)
Similarity:	157/445 - (35%)	Gaps:	125/445 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 LGVHGVRTFRRNLDWRDEEQLFRSAISINPPKAL-----------------GNLGSVLSAQGRYE 535
            :|:|.:..:.::|..::||.|    :|:...:.|                 ||...|....||..
Human    52 VGIHNLLAYVKHLKGQNEEAL----VSLKKAEDLIQKEHANQADIRSLVTWGNFAWVYYHMGRLA 112

  Fly   536 EAELTL--------RMTLGHRPTM----ADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQ---- 584
            ||:..|        :.....|..|    .|......:......|:..|..||.:|:|..|:
Human   113 EAQTYLDKVENTCKKFANPSRYRMECPEVDCEEGWALAKCGGKNYERAKTCFEKALEGNPENPEF 177

  Fly   585 ---LAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGV----------RDRGAHVEARYTCYL 636
               .|:....|.....:.|.::..::.||:...||....|          :|.|...|...  |:
Human   178 NTGYAITVYRLDKFNTASGRNKAFSLHVLKRAVRLNPDDVYIRVLLALKLQDEGQEAEGEK--YI 240

  Fly   637 QLSV---------------LYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEI------ 680
            :.::               .||..|.:..|...|:.:|:..|     ..|.||.::|..
Human   241 EEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTP-----TSAFLHHQMGLCYRAQMI 300

  Fly   681 -LAELQDW----NEAEHQQRL----------AMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFK 730
             :.|..:|    .:.|...||          .:.|:.....|||...:|.|..|.. .:||..|:
Human   301 QIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHH-RKAEEHFQ 364

  Fly   731 RALQLA----PLEPSSHHHYADFLEQQERH---------HEALGLRLRAAALAPQDYTLQSCVAD 782
            :.|::.    .|:...|:||..|   ||.|         |...||::...:.:.:
Human   365 KGLRMKIFEDQLKQEIHYHYGRF---QEHHGKSQDKAITHYLKGLKIEKMSHSRE---------- 416

  Fly   783 ALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALEL 837
              :|||.|   |...::.:........:.:.||.|.:::|...:|:.||.:||.|
Human   417 --KLLNAL---EKLAKRCIHQNVRVVESVSLLGLIHKLKGEVSDALLCYERALRL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	18/93 (19%)
		TPR repeat	518..546	CDD:276809	9/52 (17%)
		TPR repeat	551..581	CDD:276809	7/33 (21%)
		TPR_1	552..584	CDD:278916	7/31 (23%)
		TPR	565..841	CDD:223533	72/339 (21%)
		TPR repeat	586..611	CDD:276809	4/24 (17%)
		TPR repeat	634..660	CDD:276809	6/40 (15%)
		TPR repeat	671..699	CDD:276809	9/48 (19%)
		TPR repeat	704..735	CDD:276809	10/30 (33%)
		TPR repeat	740..768	CDD:276809	10/36 (28%)
		TPR repeat	773..803	CDD:276809	5/29 (17%)
		TPR	808..841	CDD:197478	10/30 (33%)
		TPR repeat	808..836	CDD:276809	8/27 (30%)
IFIT1B	NP_001010987.1	TPR_11	36..>298	CDD:330823	49/256 (19%)
		TPR 1	52..85		8/36 (22%)
		TPR repeat	54..80	CDD:276809	6/29 (21%)
		TPR 2	95..128		8/32 (25%)
		TPR repeat	97..123	CDD:276809	8/25 (32%)
		TPR repeat	128..170	CDD:276809	8/41 (20%)
		TPR 3	139..174		8/34 (24%)
		TPR 4	182..216		7/33 (21%)
		TPR repeat	216..246	CDD:276809	5/31 (16%)
		TPR 5	251..284		7/37 (19%)
		TPR repeat	251..279	CDD:276809	5/27 (19%)
		TPR repeat	284..335	CDD:276809	9/50 (18%)
		TPR_11	<323..469	CDD:330823	37/163 (23%)
		TPR 6	340..373		10/33 (30%)
		TPR repeat	340..368	CDD:276809	9/28 (32%)
		TPR 7	378..412		10/36 (28%)
		TPR repeat	378..407	CDD:276809	9/31 (29%)
		TPR 8	437..470		10/30 (33%)
		TPR repeat	437..465	CDD:276809	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810