DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31690 and CG5038

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_650451.1	Gene:	CG5038 / 41867	FlyBaseID:	FBgn0038324	Length:	705	Species:	Drosophila melanogaster

Alignment Length:	872	Identity:	239/872 - (27%)
Similarity:	352/872 - (40%)	Gaps:	215/872 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSHKDLAGLAGCSALAFVLYLNTLNAG------FVYDDRRAILANGDVTGARPL--ANLLRNDFW 71
            |.||.......|.|:..::.|.....|      ||:||..||:.|.|| .:.|.  ..:..:|||
  Fly     4 LVHKATLHSMVCQAILVLICLLCYGCGGLSGAKFVFDDTVAIVKNRDV-NSLPTNWTAIFTHDFW 67

  Fly    72 GTPLVDSGSHGSWRPLCVLSFRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTL-LP----S 131
            |..|:.|.||.|:|||..|.|...|...|::......:|::||||.|.|::.:.|:| :|    :
  Fly    68 GASLLSSDSHKSFRPLTTLMFHCEYALLGLSAAHMKFLNLLLHCVNTLLMWRLIRSLYVPEVSTA 132

  Fly   132 RMGVLAAGALFAVHPAHTEAVAGLVGRADL----ASCVCYLLAYLSYRRHMLNREWGSLILTIML 192
            |..:|:| ||||.||.|||||:|:||||:|    ...:|.||...:..|  |..:.|.||:  :|
  Fly   133 RWAILSA-ALFAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGR--LGPQTGGLIM--LL 192

  Fly   193 ALAALLCKETAITALLLCGLCDVLSPVGRENSDKVCDGSISGLASFNFQRR-----------FRS 246
            ....:|.||:|:|..:.|.|.|...               :|.....|:.:           |..
  Fly   193 TAVGMLFKESAVTIPMSCVLLDYFQ---------------NGYYHLRFKDQWSLLRTRISYLFYL 242

  Fly   247 LSILGFTLLCGLYCRLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSF 311
            |..||.     |..||......:..|...|||.||.....||.|:..||.|.|..::|.|..|.:
  Fly   243 LGTLGL-----LTARLWWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLCY 302

  Fly   312 DWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNS 376
            ||.:..|..:..:||.|.....|||..::..|            |:|           |||.|
  Fly   303 DWALGCVKLVTNIWDLRLQGVIGFYSIVLVAL------------MNF-----------RRLPG-- 342

  Fly   377 CHTWLGLTCDCHHQLSAPSYRSASAIYSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGF 441
                                                     .:|....:::||||||.:: .|||
  Fly   343 -----------------------------------------MMLALGLMIVPFLPASGII-CVGF 365

  Fly   442 VMAERVLYLPSVGYCLLFGLGFGHLW---QRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWR 503
            |:|||.||:||:|:|||...||.: |   ...|:.||:.|.:|  |.||..|..|||.:|..||.
  Fly   366 VIAERTLYVPSIGFCLLSIYGFLY-WYDSSTENTHWRTALRIL--LMLLFSVMMVRTRQRATDWL 427

  Fly   504 DEEQLFRSAISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNF 568
            :|||||:||:.:.|..                                |..|:|:..:.....|.
  Fly   428 NEEQLFKSALQVCPDN--------------------------------AKVHYNIARLATDMGNN 460

  Fly   569 SSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYT 633
            :.|...:.|||||.|....|.:|||.
  Fly   461 TKAFQHYHRAIELYPNYESALMNLGN--------------------------------------- 486

  Fly   634 CYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAM 698
                   |||..|:|..|...:|.:|:|.|..|     ...:.||.:.:....:::|......|:
  Fly   487 -------LYREHGQLSTAEEYIRLALQAYPAFP-----AAWMNLGIVQSAQGKYDKALASYEKAL 539

  Fly   699 QLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLR 763
            :.:......|...| .|.....|.|||...::.|:.|.|.:|.:..:....|:.:....:||.:.
  Fly   540 KYRANFAVCYYNMG-NLYLEQKRYAEALHHWQHAVALNPRQPKAWANILTMLDNKGLQDDALRIS 603

  Fly   764 LRAAALAPQDYTLQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAV 828
            .:|....|.|.::....|:.|..|....|||..|::.:.|:|.....|.|||.:.......:||:
  Fly   604 NQALQHLPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNTLYHTNLGVLYHRWDKTQEAI 668

  Fly   829 ACYHKALELQPGHAISRANLARMNVHK 855
            ..|..|:.:    :.:||..||.|:.|
  Fly   669 EAYRTAISI----SAARATTARENLSK 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	25/67 (37%)
		TPR_11	518..583	CDD:290150	10/64 (16%)
		TPR repeat	518..546	CDD:276809	0/27 (0%)
		TPR repeat	551..581	CDD:276809	8/29 (28%)
		TPR_1	552..584	CDD:278916	10/31 (32%)
		TPR	565..841	CDD:223533	61/275 (22%)
		TPR repeat	586..611	CDD:276809	4/24 (17%)
		TPR repeat	634..660	CDD:276809	7/25 (28%)
		TPR repeat	671..699	CDD:276809	4/27 (15%)
		TPR repeat	704..735	CDD:276809	8/30 (27%)
		TPR repeat	740..768	CDD:276809	5/27 (19%)
		TPR repeat	773..803	CDD:276809	8/29 (28%)
		TPR	808..841	CDD:197478	8/32 (25%)
		TPR repeat	808..836	CDD:276809	8/27 (30%)
CG5038	NP_650451.1	DUF1736	258..331	CDD:285594	25/72 (35%)
		TPR	442..701	CDD:223533	70/338 (21%)
		TPR_1	444..477	CDD:278916	11/32 (34%)
		TPR repeat	444..472	CDD:276809	7/27 (26%)
		TPR_17	466..499	CDD:290167	16/78 (21%)
		TPR repeat	480..506	CDD:276809	11/71 (15%)
		TPR repeat	511..541	CDD:276809	5/34 (15%)
		TPR_1	512..545	CDD:278916	5/37 (14%)
		TPR_1	546..577	CDD:278916	9/31 (29%)
		TPR repeat	546..574	CDD:276809	8/28 (29%)
		TPR repeat	580..608	CDD:276809	5/27 (19%)
		TPR repeat	614..642	CDD:276809	7/27 (26%)
		TPR repeat	647..677	CDD:276809	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750