DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and Tmtc1

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_038964827.1	Gene:	Tmtc1 / 362465	RGDID:	1564868	Length:	942	Species:	Rattus norvegicus

Alignment Length:	1007	Identity:	288/1007 - (28%)
Similarity:	417/1007 - (41%)	Gaps:	267/1007 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PSMSATLSHKDLAGLAGCSALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLA-NLLRNDFWG 72
            |:.:|.|       |.|.|.|.   |..:|...||:||..||:.|.||....||. .:..|||||
  Rat    25 PAGAAAL-------LTGASCLC---YGRSLRGEFVHDDVWAIVNNPDVRPGAPLRWAVFANDFWG 79

  Fly    73 TPLVDSGSHGSWRPLCVLSFRLNYLAGGMTPLGYHLVNVMLHCVATW-LVFLVARTLLPSRMGVL 136
            ..|.||.||.|:|||||||||||....||.|..:|.|||:|||:.|. |::...:|:..:|....
  Rat    80 KGLADSTSHKSYRPLCVLSFRLNIFLTGMNPFYFHAVNVILHCLVTLVLMYTCDKTVFKNRGLAF 144

  Fly   137 AAGALFAVHPAHTEAVAGLVGRADLASCVCYLLAYLSYRRHMLNREWGS-----------LILTI 190
            ....||||||.|||||||:|||||:.:|:.:|||:|||.| .|:::...           |:|::
  Rat   145 VTALLFAVHPVHTEAVAGIVGRADVLACLLFLLAFLSYHR-SLDQDCAGQCFPPTASPFFLLLSL 208

  Fly   191 MLALAALLCKETAITALLLCGLCDVLSPVGRENSDKVCDGSI----------------------- 232
            .|...|:|.|||.:|...:|.:.|:.||..::  ||:.:|:|
  Rat   209 FLGTCAMLVKETGVTVFGVCLVYDLFSPSHKQ--DKLSNGAICQHSPRQPGSPQPSSQQAHPHRE 271

  Fly   233 -------------------------SGL-------------ASFNFQRRF---------RSLSIL 250
                                     ||.             .:.|..|.|         |::.::
  Rat   272 SRKQRFPHRDTWGGCHSPLPPEPKSSGFPVSPRALWSLMRCLTGNSNRSFLLTLRPFLKRAILVI 336

  Fly   251 GFTLLCGLYCRLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGM 315
            .:..:. ||.||.::......||..|||.:......||.||:.||...|..:||.|..|.:||.:
  Rat   337 SYVTVI-LYFRLWIMGGTMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPITLCYDWQV 400

  Fly   316 EAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTW 380
            .::..:.|:||.||:.|.     |:|::.....|...|:              .:||.
  Rat   401 GSIPLVETIWDVRNLATI-----LLAVVMALLSLHCVAA--------------FKRLE------- 439

  Fly   381 LGLTCDCHHQLSAPSYRSASAIYSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAE 445
                   |.::.|                           |..|||.||:|||||.|.||||:||
  Rat   440 -------HKEVLA---------------------------GLLFLVFPFIPASNLFFRVGFVVAE 470

  Fly   446 RVLYLPSVGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFR 510
            ||||:||:|||:||..|...|...::....:.||  ....|||.:...:|.::|..|...|.|||
  Rat   471 RVLYMPSMGYCILFVHGLSKLCAGLSRCGATSLM--ASTVLLLLLFSWKTVKQNEIWLSRESLFR 533

  Fly   511 SAISINP--PKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIP 573
            |.:...|  .|...|..:.|..|||.:||....:..|...|..|.|..|||.:.:   :.:.|..
  Rat   534 SGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYKTALKLYPRHASALNNLGTLTK---DMAEAKM 595

  Fly   574 CFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQL 638
            .::||::|.||...|..||| :|:...:..:|||.:|:...:. |....|          .|..|
  Rat   596 YYQRALQLHPQHNRALFNLG-NLLKSQEKTEEAIVLLKESIKY-GPDFAD----------AYSSL 648

  Fly   639 SVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAE--LQDWNEAEHQQRLAMQLQ 701
            :.|.....|.::|....:..:|..|     ..:.||......|.:  ..:...|.:||  |:||.
  Rat   649 ASLLAEQERFKEAEDVYQAGIKNCP-----DSSDLHNNYAVFLVDSGFPEKAVAHYQQ--AIQLS 706

  Fly   702 PEQGAAYVTYGQTLARNGSRLAEAESWFKRALQLA----PLEPSSHHHYADFLEQQERHHEALGL 762
            |....|.|..|: |.|:....:.||.|::||||:|    .|.|....:|     ...||.|||.:
  Rat   707 PSHHVAVVNLGR-LHRSLGENSMAEEWYRRALQVARTAEVLSPLGALYY-----NTGRHKEALEV 765

  Fly   763 RLRAAALAPQDYTLQSCVADALRLLNRLAEA---------------------------------- 793
            ...|.:|.|....|:..:|..|.::.:..||
  Rat   766 YREAVSLQPSQRDLRLALAQVLAVMGQTKEAEKITSHIVSEEPRCLECYRLLSAIYSKQEHHEKA 830

  Fly   794 -------------------ELWYRK-------------------AVTLQPMAAHAHANLGAILQM 820
                               ||::.|                   ||||.|..|.|..|:|.|..:
  Rat   831 LEAIEKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYEAAVTLDPDQAQAWMNMGGIRHI 895

  Fly   821 RGLRKEAVACYHKALELQPGHAISRANLARMN 852
            :|....|...|.:||.|.|...:.:.|||:::
  Rat   896 QGSYVPARVYYERALRLVPESKLLKENLAKLD 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	24/67 (36%)
		TPR_11	518..583	CDD:290150	19/64 (30%)
		TPR repeat	518..546	CDD:276809	8/27 (30%)
		TPR repeat	551..581	CDD:276809	8/29 (28%)
		TPR_1	552..584	CDD:278916	9/31 (29%)
		TPR	565..841	CDD:223533	83/353 (24%)
		TPR repeat	586..611	CDD:276809	8/24 (33%)
		TPR repeat	634..660	CDD:276809	5/25 (20%)
		TPR repeat	671..699	CDD:276809	7/29 (24%)
		TPR repeat	704..735	CDD:276809	11/30 (37%)
		TPR repeat	740..768	CDD:276809	8/27 (30%)
		TPR repeat	773..803	CDD:276809	10/101 (10%)
		TPR	808..841	CDD:197478	12/32 (38%)
		TPR repeat	808..836	CDD:276809	9/27 (33%)
Tmtc1	XP_038964827.1	DUF1736	352..425	CDD:400627	26/77 (34%)
		PEP_TPR_lipo	<529..942	CDD:274350	107/427 (25%)
		TPR repeat	543..571	CDD:276809	8/27 (30%)
		TPR repeat	576..603	CDD:276809	8/29 (28%)
		TPR repeat	608..636	CDD:276809	9/28 (32%)
		TPR repeat	642..670	CDD:276809	6/37 (16%)
		TPR repeat	675..705	CDD:276809	7/31 (23%)
		TPR repeat	710..738	CDD:276809	10/28 (36%)
		TPR repeat	743..771	CDD:276809	9/32 (28%)
		TPR repeat	776..806	CDD:276809	5/29 (17%)
		TPR repeat	812..839	CDD:276809	0/26 (0%)
		TPR repeat	844..878	CDD:276809	5/33 (15%)
		TPR repeat	883..911	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920