DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and IFIT1

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001257856.1	Gene:	IFIT1 / 3434	HGNCID:	5407	Length:	478	Species:	Homo sapiens

Alignment Length:	442	Identity:	82/442 - (18%)
Similarity:	166/442 - (37%)	Gaps:	119/442 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 LGVHGVRTFRRNLDWRDEEQL-------------------FRSAISINPPKALGNLGSVLSAQGR 533
            :|:|.:..:.::|..::||.|                   .||.::      .||...:....||
Human    52 VGIHNLLAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVT------WGNFAWMYYHMGR 110

  Fly   534 YEEAELTL--------RMTLGHRPTM----ADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQ-- 584
            ..||:..|        :::...|..|    .|......::.....|:..|..||.:.:|:.|:
Human   111 LAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPENP 175

  Fly   585 -----LAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSG----------VRDRG--------- 625
                 .|::...|....::..:|:..::..||...||....          ::|.|
Human   176 ESSAGYAISAYRLDGFKLATKNHKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYI 240

  Fly   626 ----AHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLG-------- 678
                |::.::...:...:..||..|.:..|...|:::|:..|     ...:||.::|
Human   241 EEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETP-----TSVLLHHQIGLCYKAQMI 300

  Fly   679 EILAELQDWNEAEHQQRL-------------AMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFK 730
            :|....:.....:::::|             |::.:|....|::...:.....|:. .:||..|:
Human   301 QIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNH-RKAEENFQ 364

  Fly   731 RALQLAPLEPSS----HHHYADFLEQQERH------HEALGLRLRAAALAPQDYTLQSCVADALR 785
            :.|.:.|:...:    |.||..|.|.|::.      |....:::..|:|. :|.::.|.....||
Human   365 KLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASLT-RDKSINSLKKLVLR 428

  Fly   786 LLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALEL 837
            .|.         |||:.|:.::.     ||.:.::.|...||:..|.:||.|
Human   429 KLR---------RKALDLESLSL-----LGFVYKLEGNMNEALEYYERALRL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	15/76 (20%)
		TPR repeat	518..546	CDD:276809	7/35 (20%)
		TPR repeat	551..581	CDD:276809	6/33 (18%)
		TPR_1	552..584	CDD:278916	6/31 (19%)
		TPR	565..841	CDD:223533	64/334 (19%)
		TPR repeat	586..611	CDD:276809	3/24 (13%)
		TPR repeat	634..660	CDD:276809	5/25 (20%)
		TPR repeat	671..699	CDD:276809	6/48 (13%)
		TPR repeat	704..735	CDD:276809	6/30 (20%)
		TPR repeat	740..768	CDD:276809	7/37 (19%)
		TPR repeat	773..803	CDD:276809	8/29 (28%)
		TPR	808..841	CDD:197478	9/30 (30%)
		TPR repeat	808..836	CDD:276809	7/27 (26%)
IFIT1	NP_001257856.1	TPR 1	52..85		6/32 (19%)
		TPR_12	54..127	CDD:290160	14/78 (18%)
		TPR repeat	54..80	CDD:276809	5/25 (20%)
		TPR 2	95..128		7/38 (18%)
		TPR repeat	97..123	CDD:276809	7/31 (23%)
		TPR repeat	128..170	CDD:276809	7/41 (17%)
		TPR 3	139..174		7/34 (21%)
		TPR 4	183..216		6/32 (19%)
		TPR repeat	216..246	CDD:276809	2/29 (7%)
		TPR 5	218..249		3/30 (10%)
		TPR 6	251..284		7/37 (19%)
		TPR repeat	252..279	CDD:276809	5/26 (19%)
		Interaction with the 5'-triphosphate group of PPP-RNA. /evidence=ECO:0000250	256..262		0/5 (0%)
		TPR repeat	284..335	CDD:276809	6/50 (12%)
		TPR 7	305..339		3/33 (9%)
		TPR 8	340..373		7/33 (21%)
		TPR repeat	340..367	CDD:276809	5/27 (19%)
		TPR 9	378..412		7/33 (21%)
		TPR repeat	378..407	CDD:276809	7/28 (25%)
		TPR 10	437..470		10/35 (29%)
		TPR repeat	437..465	CDD:276809	8/32 (25%)
		TPR_1	438..470	CDD:278916	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810