DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and IFIT2

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001538.4	Gene:	IFIT2 / 3433	HGNCID:	5409	Length:	472	Species:	Homo sapiens

Alignment Length:	318	Identity:	64/318 - (20%)
Similarity:	112/318 - (35%)	Gaps:	68/318 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 HQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGA 626
            |.|..| .:|:.|.|:|.||..|.......: .||::.|::   |......|...:.....|:..
Human    62 HLKGQN-EAALECLRKAEELIQQEHADQAEI-RSLVTWGNY---AWVYYHMGRLSDVQIYVDKVK 121

  Fly   627 HVEARYTCYLQLS----------VLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEIL 681
            ||..:::...::.          ...:..|...:.|....|  |||...|:.......|.:...
Human   122 HVCEKFSSPYRIESPELDCEEGWTRLKCGGNQNERAKVCFE--KALEKKPKNPEFTSGLAIASY- 183

  Fly   682 AELQDWNEAEH---QQRLAMQLQPEQGAAYVTYGQTLAR---NGSRLAEAESWFKRALQLAPLEP 740
             .|.:|..:::   ..|.|::|.|:.....|.....|.:   .|....|.|...:.||:.||...
Human   184 -RLDNWPPSQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVT 247

  Fly   741 SSHHHYADFLEQQERHHEALGLRLRAAALAPQDYTLQSCVADALRLLNRLAEAELWYRKAVTLQP 805
            ......|.|..:::...:|:.|                                  .:||:...|
Human   248 DVLRSAAKFYRRKDEPDKAIEL----------------------------------LKKALEYIP 278

  Fly   806 MAAHAHANLGA-----ILQMRGLRKEAVACYHKALELQPGHAIS---RANLARMNVHK 855
            ..|:.|..:|.     :.|:..||:..:....|.||| .|||::   :|:.|..|:.:
Human   279 NNAYLHCQIGCCYRAKVFQVMNLRENGMYGKRKLLEL-IGHAVAHLKKADEANDNLFR 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	9/20 (45%)
		TPR repeat	518..546	CDD:276809
		TPR repeat	551..581	CDD:276809	7/18 (39%)
		TPR_1	552..584	CDD:278916	9/21 (43%)
		TPR	565..841	CDD:223533	56/296 (19%)
		TPR repeat	586..611	CDD:276809	4/24 (17%)
		TPR repeat	634..660	CDD:276809	3/35 (9%)
		TPR repeat	671..699	CDD:276809	5/30 (17%)
		TPR repeat	704..735	CDD:276809	7/33 (21%)
		TPR repeat	740..768	CDD:276809	4/27 (15%)
		TPR repeat	773..803	CDD:276809	2/29 (7%)
		TPR	808..841	CDD:197478	10/37 (27%)
		TPR repeat	808..836	CDD:276809	7/32 (22%)
IFIT2	NP_001538.4	TPR_12	51..112	CDD:290160	15/54 (28%)
		TPR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	51..89		10/27 (37%)
		TPR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	90..135		8/48 (17%)
		TPR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	136..171		7/36 (19%)
		TPR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	172..208		7/37 (19%)
		TPR repeat	208..236	CDD:276809	5/27 (19%)
		TPR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	247..280		7/66 (11%)
		TPR repeat	248..275	CDD:276809	6/60 (10%)
		TPR repeat	280..329	CDD:276809	14/49 (29%)
		TPR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	281..335		16/54 (30%)
		TPR repeat	334..359	CDD:276809	0/2 (0%)
		TPR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	336..366		64/318 (20%)
		TPR 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	367..405
		TPR 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	406..448
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810