DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc1 and TTC6

DIOPT Version :10

Sequence 1:NP_995615.2 Gene:Tmtc1 / 33455 FlyBaseID:FBgn0051690 Length:859 Species:Drosophila melanogaster
Sequence 2:XP_047287288.1 Gene:TTC6 / 319089 HGNCID:19739 Length:1894 Species:Homo sapiens


Alignment Length:901 Identity:172/901 - (19%)
Similarity:291/901 - (32%) Gaps:353/901 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 VDSGSHGSWR--------PLCVLS--------FRLNYLAGGMTPL-----------------GYH 107
            :|:.:...|:        |||:.|        |:|:.|...:..|                 |.:
Human  1203 LDNYTEAIWQFSEAIRIDPLCIQSYLCRAETYFKLHKLKKAVNELSRAIHLQPDGIQLYIRRGQY 1267

  Fly   108 LVNVMLHCVATWLVFLVA---RTLLPSRMGVLAAGALFAVHPAHTEAVAGLVG----RADLASCV 165
            |:.:..:.:|.:.::.:|   :.|  |.:..:....:::....|.:|:..|.|    ||::.  :
Human  1268 LLMMKYYDLAKFTIYQIAEMDKGL--SELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMT--M 1328

  Fly   166 CYLLAYLSYRRHMLNREWGSLILTIMLALAALLCKE-----TAITA--LLLCGLC---------- 213
            |.|||    :..|..:.....:..:..||.|:...:     |||:|  |...|||          
Human  1329 CALLA----KVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMA 1389

  Fly   214 -DVLSPVGRENSD-----------KVCDGSISGLASFN---------FQRRFRS-----LSILGF 252
             |..:...:.|.|           ||.....|.:..||         :|.....     ||.:.|
Human  1390 FDSFTKAVKANPDFAESFYQRGLCKVKLHKDSSILDFNRAITLNPKHYQEMHTGGLGAYLSRVAF 1454

  Fly   253 TLLCGLYCR--------LSLLPRPSTAF---------------SAADNPTA------HESCFWTR 288
            ..|.|.|.:        :.:.|....|:               :..|..||      ..:.|:.|
Human  1455 YGLKGRYSKAILNCNKAIKIYPESVRAYLYRGVLKYYNKTYKLAITDLTTAISMDKNSYTAFYNR 1519

  Fly   289 TLTF-----LYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSG 348
            .|.:     |.:.:.::||:|.         ::|...::    ....|..|..  .|.:...|..
Human  1520 ALCYTKIRELQMALTDYGIVLL---------LDATETVK----LNTFLNRGLI--YVELGQYGFA 1569

  Fly   349 LRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQLSAPSYRSASAIYSTSSKSKSAS 413
            |.      ||.:.|     |:.|..|:.||.    |..|||:::  .:..|...:         :
Human  1570 LE------DFKQAA-----LISRTNGSLCHA----TAMCHHRIN--EFEEAVNFF---------T 1608

  Fly   414 WTAAPILGTAFLVLP-FLPASNLLFYVGFVMAERVLYLPSVGYCLLFGLGFGHLWQRVNSSWRSR 477
            |        |..:.| ||.|     |||                                  |..
Human  1609 W--------ALKINPCFLDA-----YVG----------------------------------RGN 1626

  Fly   478 LMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINPP--KALGNLGSVLSAQGRYEEAELT 540
            ..:..|       |...|.:...|       |..|:.|||.  ||..:.|..|.|||::::|.  
Human  1627 SYMEYG-------HDEATKQAQKD-------FLKALHINPAYIKARISFGYNLQAQGKFQKAW-- 1675

  Fly   541 LRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQE 605
                         .||.:                   ||:..|:..:||                
Human  1676 -------------NHFTI-------------------AIDTDPKNYLAY---------------- 1692

  Fly   606 AISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQR 670
                                   |.|....||:.   .:...:||..||::.|..|..|   ..|
Human  1693 -----------------------EGRAVVCLQMG---NNFAAMQDINAAMKISTTAEFL---TNR 1728

  Fly   671 AVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQL 735
            .|:|..:|.....::|:.:       |:.|.|:...||...|.....: .:.::|..:|.:||:.
Human  1729 GVIHEFMGHKQNAMKDYQD-------AITLNPKYSLAYFNAGNIYFHH-RQFSQASDYFSKALKF 1785

  Fly   736 APLEPSSHHHYADFLEQQERHHEALGLRLRAAAL-----APQDY--TLQSCVADALRLLNR---- 789
            .|                |..:..:...:....|     |.:|:  .::||...|....||    
Human  1786 DP----------------ENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFY 1834

  Fly   790 -------LAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQ 838
                   |||.:|  .||::|:|..|..:.....:....||.:||:|.|::||:|:
Human  1835 YCLKQYELAEEDL--NKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1888

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc1NP_995615.2 ArnT 11..>209 CDD:441412 35/179 (20%)
TMTC_DUF1736 271..340 CDD:462468 14/94 (15%)
PilF 501..585 CDD:442297 19/85 (22%)
TPR repeat 518..546 CDD:276809 8/29 (28%)
TPR repeat 551..581 CDD:276809 4/29 (14%)
LapB 556..838 CDD:442196 59/299 (20%)
TPR repeat 586..611 CDD:276809 2/24 (8%)
TPR repeat 634..660 CDD:276809 7/25 (28%)
TPR repeat 671..699 CDD:276809 5/27 (19%)
TPR repeat 704..735 CDD:276809 7/30 (23%)
TPR repeat 740..768 CDD:276809 1/27 (4%)
TPR repeat 773..803 CDD:276809 12/42 (29%)
TPR repeat 808..836 CDD:276809 8/27 (30%)
TTC6XP_047287288.1 TPR repeat 917..945 CDD:276809
PEP_TPR_lipo 924..1816 CDD:274350 149/825 (18%)
TPR repeat 950..980 CDD:276809
TPR repeat 986..1013 CDD:276809
TPR repeat 1018..1047 CDD:276809
TPR repeat 1053..1080 CDD:276809
TPR repeat 1085..1115 CDD:276809
TPR repeat 1157..1183 CDD:276809
TPR repeat 1191..1218 CDD:276809 2/14 (14%)
TPR repeat 1223..1253 CDD:276809 6/29 (21%)
TPR repeat 1292..1317 CDD:276809 3/24 (13%)
TPR repeat 1331..1354 CDD:276809 5/26 (19%)
TPR repeat 1370..1398 CDD:276809 6/27 (22%)
TPR repeat 1403..1432 CDD:276809 5/28 (18%)
TPR repeat 1447..1473 CDD:276809 6/25 (24%)
TPR repeat 1478..1508 CDD:276809 4/29 (14%)
TPR repeat 1513..1536 CDD:276809 4/22 (18%)
TPR repeat 1552..1578 CDD:276809 8/38 (21%)
TPR repeat 1583..1613 CDD:276809 10/52 (19%)
TPR repeat 1618..1648 CDD:276809 11/82 (13%)
TPR repeat 1655..1683 CDD:276809 11/61 (18%)
TPR repeat 1688..1718 CDD:276809 10/71 (14%)
TPR 1722..>1891 CDD:440225 45/196 (23%)
TPR repeat 1722..1750 CDD:276809 8/37 (22%)
TPR repeat 1758..1784 CDD:276809 6/26 (23%)
TPR repeat 1789..1819 CDD:276809 3/29 (10%)
TPR repeat 1824..1852 CDD:276809 9/29 (31%)
TPR repeat 1858..1886 CDD:276809 8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

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