Protein Alignment Tmtc1 and Tmtc2

DIOPT Version :10

• Sequence 1: NP_995615.2
• Gene: Tmtc1 / 33455
• FlyBaseID: FBgn0051690
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_001164648.2
• Gene: Tmtc2 / 299762
• RGDID: 1309848
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 856
• Identity: 315/856 - (36%)
• Similarity: 456/856 - (53%)
• Gaps: 72/856 - (8%)

  Fly    27 SALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVLS 91
            |||...||||||:|.|.|||.|||..|.|:....|..::..||||||.|..||||.|:||||.||
  Rat     8 SALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLS 72

  Fly    92 FRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLPSRMGVLAAGALFAVHPAHTEAVAGLV 156
            ||||:..||:.|..||||||:||...|.|....::.||........||.:||.||.|||||||:|
  Rat    73 FRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTRFSKALLGDGYWTFMAGLMFASHPIHTEAVAGIV 137

  Fly   157 GRADLASCVCYLLAYLSYRRHMLN-----REWGSLILTIMLALAALLCKETAITALLLCGLCDVL 216
            ||||:.:.:.:||:.|.|.:|...     |.||..:.|.:.|..::|.||..:|.|.:..:.||
  Rat   138 GRADVGASLFFLLSLLCYTKHCSTRGYSARTWGWFLGTGLCAGCSMLWKEQGVTVLAVSAVYDV- 201

  Fly   217 SPVGRENSDKVCDGSISGLASFNFQR-----------------RFRSLSILGF--TLLCGLYCRL 262
                                 |.|.|                 .|.|:|:|.|  |.|.|  .||
  Rat   202 ---------------------FVFHRLKMRQILPTIYKRKNLSLFLSISLLTFWGTSLLG--ARL 243

  Fly   263 SLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDA 327
            ..:.....:||.:|||.|.......|||||.|||..|..:||.|..|||||.|:||..::|:.|.
  Rat   244 YWMGNKPPSFSNSDNPAADSDSLLARTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDW 308

  Fly   328 RNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQLS 392
            ||:.|..||..|:.:.:.|....|.....:...|.|..    :...|:||::      |..::.|
  Rat   309 RNLHTVAFYSGLLLLAYCGLKSPSLEGECNGKAVTNGK----QNANGHSCYS------DVEYRNS 363

  Fly   393 --APSYRS--ASAIYS-TSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPS 452
              .||:.|  .:.|.| .|.:.:..|.....||..:.|::||:||:||.||||||:||||||:||
  Rat   364 EIKPSFASKVENGIKSCVSQRPQLPSTENIVILSLSLLIIPFIPATNLFFYVGFVIAERVLYIPS 428

  Fly   453 VGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINP 517
            :|:|||..:|...|:.:|...:...|:.. ..|.|:..:|::|..||.||::||.|:||.|.:||
  Rat   429 MGFCLLITVGARALYVKVQKRFLKSLVFY-ATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP 492

  Fly   518 PKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELR 582
            .||.||||:||.:|.:..|||:..|..|.:|..|||..:|||::.|:...|:.|:..::.|:..|
  Rat   493 AKAWGNLGNVLKSQSKISEAEIAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAVGSR 557

  Fly   583 PQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGR 647
            |.||.||||.|..|::.| ..:||.......:.:....::|..||..:..:|...|..||...||
  Rat   558 PTLASAYLNTGIILMNQG-KTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGR 621

  Fly   648 LQDAAAALRESLKALP--LLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVT 710
            .::|.:..||:::.:|  ..||.    |:..:||....|....||||....:::.:.:...|::|
  Rat   622 YEEALSVYREAIQKMPRQFAPQS----LYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLT 682

  Fly   711 YGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDYT 775
            ||:.||..| |.:|||.:|.:|::|.|.:.:.:.||..||.::.|..||..:..:||.|...::.
  Rat   683 YGKLLALTG-RKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELDSTEFD 746

  Fly   776 LQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQPG 840
            :....|..||..:....||.:|..|..|:|....|..||||||.:.|..::|.|.|.:||:|:|.
  Rat   747 VVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPD 811

  Fly   841 HAISRANLARM 851
            ..|:::||.::
  Rat   812 DVITQSNLRKL 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc1	NP_995615.2	ArnT	11..>209	CDD:441412	90/186 (48%)
		TMTC_DUF1736	271..340	CDD:462468	33/68 (49%)
		PilF	501..585	CDD:442297	37/83 (45%)
		TPR repeat	518..546	CDD:276809	13/27 (48%)
		TPR repeat	551..581	CDD:276809	10/29 (34%)
		LapB	556..838	CDD:442196	90/283 (32%)
		TPR repeat	586..611	CDD:276809	10/24 (42%)
		TPR repeat	634..660	CDD:276809	9/25 (36%)
		TPR repeat	671..699	CDD:276809	8/27 (30%)
		TPR repeat	704..735	CDD:276809	13/30 (43%)
		TPR repeat	740..768	CDD:276809	8/27 (30%)
		TPR repeat	773..803	CDD:276809	7/29 (24%)
		TPR repeat	808..836	CDD:276809	12/27 (44%)
Tmtc2	NP_001164648.2	ArnT	<78..>198	CDD:441412	48/119 (40%)
		TMTC_DUF1736	247..321	CDD:462468	33/73 (45%)
		TadD	439..558	CDD:444034	44/119 (37%)
		TPR repeat	493..521	CDD:276809	13/27 (48%)
		LapB	511..807	CDD:442196	98/301 (33%)
		TPR repeat	527..555	CDD:276809	9/27 (33%)
		TPR repeat	560..590	CDD:276809	11/30 (37%)
		TPR repeat	595..634	CDD:276809	12/38 (32%)
		TPR repeat	642..671	CDD:276809	10/32 (31%)
		TPR repeat	679..705	CDD:276809	13/26 (50%)
		TPR repeat	710..774	CDD:276809	17/63 (27%)
		TPR repeat	779..807	CDD:276809	12/27 (44%)