DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31690 and Ifit2

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001019924.1	Gene:	Ifit2 / 294091	RGDID:	1307804	Length:	464	Species:	Rattus norvegicus

Alignment Length:	364	Identity:	76/364 - (20%)
Similarity:	122/364 - (33%)	Gaps:	103/364 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 DW---RDEEQLFRSAISINPPKALGNLGSVLSAQGRYE-EAELTLRMTLGHRPTMADAHFNLGVV 561
            ||   .|.......|||::|......:...:..:..:| .|:..:...|...|:..|........
  Rat   187 DWPASNDYIDSLEQAISLSPDNTYVKVLLAMKLEEVHENRAKELVEEALKKDPSAIDTMLGAAKF 251

  Fly   562 HQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGA 626
            :.|..:...||...::|:|..|..|..:..||..      :|.:.:.:|.|...
  Rat   252 YVKVHDTDRAIQLLKKALESMPNNAYVHYYLGCC------YRSKVLHILNTEET----------- 299

  Fly   627 HVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAE 691
                            .|:|.        ||.|:||     .|.|:.|||..|.:.|:.: |...
  Rat   300 ----------------TSNGN--------REKLEAL-----IQPALNHLRKAEDIKEMIE-NSCS 334

  Fly   692 HQQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRAL--QLAPLEPSS--HHHYADF--- 749
            |...|           |||..|        ..||:.:|::..  .|.|| |..  |..|.:|
  Rat   335 HLAGL-----------YVTTKQ--------YEEADYYFQKEFNKDLRPL-PKQLLHLRYGNFQFY 379

  Fly   750 ---LEQQERHHEALGLRLRAAALAPQDYTLQSCVADALR--LLNRLAEAELWYRKAVTLQPMAAH 809
               .|.:..:|...|:::.      ::...:..:.|.||  .|.||:..|        ..|.|..
  Rat   380 ERKCEDRAIYHYMEGVKIN------RESKPKGKMRDKLRKLALRRLSRDE--------SDPEALR 430

  Fly   810 AHANLGAILQMRGLRKEAVACYHKALELQPGHAISRANL 848
            ..|.|....:.:|..|.:..      |..||:.:..|:|
  Rat   431 ILAFLREHREGQGADKASEG------EEDPGNRVPSASL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	10/65 (15%)
		TPR repeat	518..546	CDD:276809	2/28 (7%)
		TPR repeat	551..581	CDD:276809	5/29 (17%)
		TPR_1	552..584	CDD:278916	6/31 (19%)
		TPR	565..841	CDD:223533	60/287 (21%)
		TPR repeat	586..611	CDD:276809	4/24 (17%)
		TPR repeat	634..660	CDD:276809	4/25 (16%)
		TPR repeat	671..699	CDD:276809	9/27 (33%)
		TPR repeat	704..735	CDD:276809	7/32 (22%)
		TPR repeat	740..768	CDD:276809	7/35 (20%)
		TPR repeat	773..803	CDD:276809	7/31 (23%)
		TPR	808..841	CDD:197478	6/32 (19%)
		TPR repeat	808..836	CDD:276809	4/27 (15%)
Ifit2	NP_001019924.1	TPR_12	51..126	CDD:290160
		TPR repeat	96..122	CDD:276809
		TPR repeat	127..167	CDD:276809
		TPR repeat	242..270	CDD:276809	5/27 (19%)
		TPR repeat	275..325	CDD:276809	19/95 (20%)
		TPR repeat	330..355	CDD:276809	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810