DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31690 and Tmtc4

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_006252585.1	Gene:	Tmtc4 / 290501	RGDID:	1560183	Length:	773	Species:	Rattus norvegicus

Alignment Length:	864	Identity:	253/864 - (29%)
Similarity:	382/864 - (44%)	Gaps:	196/864 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVLSFR 93
            ::.:.:..:.:..||:||..||:.|.|:....|||:|..:||||:.|..:.||.|:|||.||:||
  Rat    60 VSLLCFARSYDGDFVFDDSEAIVNNKDLQSDTPLADLWHHDFWGSRLSSNTSHKSYRPLTVLTFR 124

  Fly    94 LN-YLAGGMTPLGYHLVNVMLHCVATWL---VFLV-----------ARTLLPSRMGVLAAGALFA 143
            :| ||:||..|:|:|:||::||...:.|   ||.|           .|..|..|..:||| .|||
  Rat   125 VNYYLSGGFHPVGFHVVNILLHGGISILMLDVFSVLFGGLQYSSKGRRVHLAPRASLLAA-LLFA 188

  Fly   144 VHPAHTEAVAGLVGRADLASCVCYLLAYLSYRRHML---NRE-------WGSLILTIMLALAALL 198
            |||.|||.|||:||||||...:.:||::|.|.|...   |:|       |  ::|:|.|...|:|
  Rat   189 VHPVHTECVAGVVGRADLLCALFFLLSFLGYCRAFKETGNKEGTHSSTFW--VLLSIFLGAVAML 251

  Fly   199 CKETAITAL--------LLCGLCDVLSPVGRE-NSDKVCDGSISGLASFNFQRRFRSLSILGFTL 254
            |||..:|.|        |:.|..|:|..|.:. ..||..: |...|.:.....|...|:|.|.|:
  Rat   252 CKEQGVTVLGLNAVFDILVIGRLDILVAVRKVLRKDKSLE-STGMLKNGGLLFRMALLTIGGSTM 315

  Fly   255 LCGLYCRLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVS 319
               ||.|..::.....||:..|||.:.......|.:.:.|....|..:||.|..|.|||.|..:.
  Rat   316 ---LYIRWKIMGTGPPAFTEVDNPASFADSVLVRAINYNYYYSLNAWLLLCPWWLCFDWSMGCIP 377

  Fly   320 RIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLT 384
            .|:::.|.|.|..|..:..|:.::::      |....|..:         ||:          ||
  Rat   378 LIKSVGDWRVIALAALWLCLIGLIFQ------ALCSEDSCK---------RRI----------LT 417

  Fly   385 CDCHHQLSAPSYRSASAIYSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLY 449
                                               ||..|||:||||||||.|.||||:||||||
  Rat   418 -----------------------------------LGLGFLVIPFLPASNLFFRVGFVVAERVLY 447

  Fly   450 LPSVGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAIS 514
            |||.|||:|...|||.| .|.....:....::.|:.|   ::.:|...|:.:||.|::|||||:|
  Rat   448 LPSAGYCMLLTFGFGTL-SRHTKKKKPVAAIILGILL---INALRCVIRSGEWRSEDRLFRSALS 508

  Fly   515 INPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAI 579
            :.|          |:|:                      .|:|:|.....|.|.::||..:|.|:
  Rat   509 VCP----------LNAK----------------------VHYNIGKNLADQGNQTAAIKYYREAV 541

  Fly   580 ELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRS 644
            .|.|:...|..||| :::...:..|||..:|....:::    .|..|       .::.|.::..|
  Rat   542 RLNPKYVHAMNNLG-NILKERNELQEAEELLSLAVQIQ----PDFAA-------AWMNLGIVQNS 594

  Fly   645 DGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYV 709
            ..|.::|..:.|.::|.....|.     .:..||.:.|:|....:|.:..|.|..::||...|:.
  Rat   595 LKRFEEAEQSYRTAIKHRRKYPD-----CYYNLGRLYADLNRHVDALNAWRNATVMKPEHSLAWN 654

  Fly   710 TYGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDY 774
            .. ..|..|...||:||:..:.|||                                  |.|.|:
  Rat   655 NM-VILLDNTGNLAQAEAVGREALQ----------------------------------LIPNDH 684

  Fly   775 TLQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQP 839
            :|...:|:.|....:..|:|..:.||:...|..|..|.||..:....|....|...|..:|:|.|
  Rat   685 SLMFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDP 749

  Fly   840 -------GHAISRANLARM 851
                   .:::.|..|.:|
  Rat   750 VAVGTKENYSLLRRKLEQM 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	20/67 (30%)
		TPR_11	518..583	CDD:290150	12/64 (19%)
		TPR repeat	518..546	CDD:276809	2/27 (7%)
		TPR repeat	551..581	CDD:276809	9/29 (31%)
		TPR_1	552..584	CDD:278916	10/31 (32%)
		TPR	565..841	CDD:223533	65/282 (23%)
		TPR repeat	586..611	CDD:276809	7/24 (29%)
		TPR repeat	634..660	CDD:276809	5/25 (20%)
		TPR repeat	671..699	CDD:276809	7/27 (26%)
		TPR repeat	704..735	CDD:276809	9/30 (30%)
		TPR repeat	740..768	CDD:276809	0/27 (0%)
		TPR repeat	773..803	CDD:276809	8/29 (28%)
		TPR	808..841	CDD:197478	10/39 (26%)
		TPR repeat	808..836	CDD:276809	7/27 (26%)
Tmtc4	XP_006252585.1	DUF1736	324..398	CDD:285594	21/73 (29%)
		TPR	513..771	CDD:223533	72/330 (22%)
		TPR_1	514..547	CDD:278916	12/54 (22%)
		TPR repeat	514..542	CDD:276809	10/49 (20%)
		TPR_17	536..569	CDD:290167	11/33 (33%)
		TPR repeat	547..577	CDD:276809	8/30 (27%)
		TPR_1	582..615	CDD:278916	7/39 (18%)
		TPR repeat	582..610	CDD:276809	6/34 (18%)
		TPR repeat	616..642	CDD:276809	7/30 (23%)
		TPR repeat	650..678	CDD:276809	8/28 (29%)
		TPR repeat	683..713	CDD:276809	8/29 (28%)
		TPR_17	706..739	CDD:290167	9/32 (28%)
		TPR repeat	718..746	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820