Protein Alignment Tmtc1 and Tmtc2

DIOPT Version :10

• Sequence 1: NP_995615.2
• Gene: Tmtc1 / 33455
• FlyBaseID: FBgn0051690
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_796342.2
• Gene: Tmtc2 / 278279
• MGIID: 1914057
• Length: 836
• Species: Mus musculus
• Alignment Length: 861
• Identity: 315/861 - (36%)
• Similarity: 451/861 - (52%)
• Gaps: 82/861 - (9%)

  Fly    27 SALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVLS 91
            |||...||||||:|.|.|||.|||..|.|:....|..::..||||||.|..||||.|:||||.||
Mouse     8 SALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLS 72

  Fly    92 FRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLPSRMGVLAAGALFAVHPAHTEAVAGLV 156
            ||||:..||:.|..||||||:||...|.|....::.||........||.:||.||.|||||||:|
Mouse    73 FRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTRFSKALLGDGYWTFMAGLMFASHPIHTEAVAGIV 137

  Fly   157 GRADLASCVCYLLAYLSYRRHMLN-----REWGSLILTIMLALAALLCKETAITALLLCGLCDVL 216
            ||||:.:.:.:||:.|.|.:|...     |.||..:.|.:.|..::|.||..:|.|.:..:.||
Mouse   138 GRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGTGLCAGCSMLWKEQGVTVLAVSAVYDV- 201

  Fly   217 SPVGRENSDKVCDGSISGLASFNFQR-----------------RFRSLSILGFTLLCGLYCRLSL 264
                                 |.|.|                 .|.|:|:|.|...|.|..||..
Mouse   202 ---------------------FVFHRLKMKQILPTIYKRKNLSLFLSISLLTFWGTCLLGARLYW 245

  Fly   265 LPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARN 329
            :.....:||.:|||.|.......|||||||||..|..:||.|..|||||.|:||..::|:.|.||
Mouse   246 MGNKPPSFSNSDNPAADSDSLLARTLTFLYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRN 310

  Fly   330 ILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQLSAP 394
            :.|..||..|:.:.:.|....|.....:...:.|..    :...|:|||             |..
Mouse   311 LHTVAFYSGLLLLAYCGLKNPSLEGECNGKALTNGK----QNANGHSCH-------------SDV 358

  Fly   395 SYRSASAIYSTSSKSKSASWTAAP------------ILGTAFLVLPFLPASNLLFYVGFVMAERV 447
            .||::....|.:||.::......|            ||..:.|::||:||:||.||||||:||||
Mouse   359 EYRNSEMKPSFASKVENGIKNCVPQRTQLPSTENIVILSLSLLIIPFIPATNLFFYVGFVIAERV 423

  Fly   448 LYLPSVGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSA 512
            ||:||:|:|||..:|...|:.:|...:...|:.. ..|.|:..:||:|..||.||::||.|:||.
Mouse   424 LYIPSMGFCLLITVGARALYVKVQKRFLKSLVFY-ATATLIVFYGVKTAIRNGDWQNEEMLYRSG 487

  Fly   513 ISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRR 577
            |.:||.||.||||:||.:|.:..|||...|..|.:|..|||..:|||::.|:...|:.|:..::.
Mouse   488 IKVNPAKAWGNLGNVLKSQSKISEAESAYRNALFYRSNMADMLYNLGLLLQENSRFAEALHYYKL 552

  Fly   578 AIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLY 642
            ||..||.||.||||.|..|::.| ..:||.......:.:....::|..||..:..:|...|..||
Mouse   553 AIGSRPTLASAYLNTGIILMNQG-KTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLY 616

  Fly   643 RSDGRLQDAAAALRESLKALP--LLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQG 705
            ...||.::|.:..||:::.:|  ..||.    |:..:||....|....||||....:::.:.:..
Mouse   617 HEQGRYEEALSVYREAIQKMPRHFAPQS----LYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHI 677

  Fly   706 AAYVTYGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALA 770
            .|::|||:.||..| |.:|||.:|.:|::|.|.:.:.:.||..||.::.|..||..:..:||.|.
Mouse   678 PAHLTYGKLLALTG-RKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELD 741

  Fly   771 PQDYTLQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKAL 835
            ..::.:....|..||..:....||.:|..|..|:|....|..||||||.:.|..::|.|.|.:||
Mouse   742 NTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRAL 806

  Fly   836 ELQPGHAISRANLARM 851
            :|:|...|:::||.::
Mouse   807 QLKPDDVITQSNLRKL 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc1	NP_995615.2	ArnT	11..>209	CDD:441412	90/186 (48%)
		TMTC_DUF1736	271..340	CDD:462468	34/68 (50%)
		PilF	501..585	CDD:442297	38/83 (46%)
		TPR repeat	518..546	CDD:276809	13/27 (48%)
		TPR repeat	551..581	CDD:276809	11/29 (38%)
		LapB	556..838	CDD:442196	91/283 (32%)
		TPR repeat	586..611	CDD:276809	10/24 (42%)
		TPR repeat	634..660	CDD:276809	9/25 (36%)
		TPR repeat	671..699	CDD:276809	8/27 (30%)
		TPR repeat	704..735	CDD:276809	13/30 (43%)
		TPR repeat	740..768	CDD:276809	8/27 (30%)
		TPR repeat	773..803	CDD:276809	7/29 (24%)
		TPR repeat	808..836	CDD:276809	12/27 (44%)
Tmtc2	NP_796342.2	ArnT	<78..>198	CDD:441412	48/119 (40%)
		TMTC_DUF1736	247..321	CDD:462468	34/73 (47%)
		TPR	488..707	CDD:440225	78/224 (35%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	493..526		15/32 (47%)
		TPR repeat	493..521	CDD:276809	13/27 (48%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	527..560		12/32 (38%)
		TPR repeat	527..555	CDD:276809	9/27 (33%)
		TPR repeat	560..590	CDD:276809	11/30 (37%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	561..594		10/33 (30%)
		TPR repeat	595..634	CDD:276809	12/38 (32%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	606..639		10/32 (31%)
		TPR	608..>812	CDD:440225	69/208 (33%)
		TPR repeat	642..671	CDD:276809	10/32 (31%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	643..676		9/36 (25%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	677..710		15/33 (45%)
		TPR repeat	679..705	CDD:276809	13/26 (50%)
		TPR repeat	710..774	CDD:276809	17/63 (27%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	711..744		10/32 (31%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	745..778		9/32 (28%)
		TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	779..812		15/32 (47%)
		TPR repeat	779..807	CDD:276809	12/27 (44%)