DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31690 and IFIT5

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_036552.1	Gene:	IFIT5 / 24138	HGNCID:	13328	Length:	482	Species:	Homo sapiens

Alignment Length:	412	Identity:	83/412 - (20%)
Similarity:	151/412 - (36%)	Gaps:	116/412 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 NLDWRDEEQLFRSAISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNL----G 559
            ::|..:|.|.:...|        ||:...||:...|:         |....|..:..:.|    |
Human   106 HMDQLEEAQKYTGKI--------GNVCKKLSSPSNYK---------LECPETDCEKGWALLKFGG 153

  Fly   560 VVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQE------AISVLRTGARLEG 618
            ..:||      |...|.:|:|:.|......:....::..|.|..:|      ::..||....|..
Human   154 KYYQK------AKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGPLRKAVTLNP 212

  Fly   619 S--------GVRDRGAHVEARYTCYLQ---------------LSVLYRSDGRLQDAAAALRESLK 660
            .        .::.:..|.||....|::               .:..||.......|...|:::|:
Human   213 DNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYVLRYAAKFYRRKNSWNKALELLKKALE 277

  Fly   661 ALPLLPQKQRAVLHLRLGEIL-AELQDWNEAEHQQ--------------------RLAMQLQPEQ 704
            ..|     ..:.||.::|... |::....:|.|.:                    :.||:.....
Human   278 VTP-----TSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDELISSAIFHFKAAMERDSMF 337

  Fly   705 GAAYVTYGQTLARNGSRLAEAESWFKRALQLAPL----EPSSHHHYADFLEQQER------HH-- 757
            ..||.......| .|.:.:.||..|::||:|..:    :...|:||..|.|...:      ||
Human   338 AFAYTDLANMYA-EGGQYSNAEDIFRKALRLENITDDHKHQIHYHYGRFQEFHRKSENTAIHHYL 401

  Fly   758 EALGLRLRAAALAPQDYTLQSCVADALRLLN--RLAEAELWYRKAVTLQPMAAHAHANLGAILQM 820
            |||.::.|:        .|::.:..||:.|:  ||.      ..|:.:|.::|     ||.:.::
Human   402 EALKVKDRS--------PLRTKLTSALKKLSTKRLC------HNALDVQSLSA-----LGFVYKL 447

  Fly   821 RGLRKEAVACYHKALELQPGHA 842
            .|.:::|...|.||.::.|.:|
Human   448 EGEKRQAAEYYEKAQKIDPENA 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	15/68 (22%)
		TPR repeat	518..546	CDD:276809	5/27 (19%)
		TPR repeat	551..581	CDD:276809	7/33 (21%)
		TPR_1	552..584	CDD:278916	8/35 (23%)
		TPR	565..841	CDD:223533	67/339 (20%)
		TPR repeat	586..611	CDD:276809	3/30 (10%)
		TPR repeat	634..660	CDD:276809	5/40 (13%)
		TPR repeat	671..699	CDD:276809	7/48 (15%)
		TPR repeat	704..735	CDD:276809	9/30 (30%)
		TPR repeat	740..768	CDD:276809	11/35 (31%)
		TPR repeat	773..803	CDD:276809	7/31 (23%)
		TPR	808..841	CDD:197478	9/32 (28%)
		TPR repeat	808..836	CDD:276809	8/27 (30%)
IFIT5	NP_036552.1	TPR_12	49..116	CDD:315987	3/9 (33%)
		TPR 1	51..84
		TPR repeat	53..79	CDD:276809
		TPR repeat	84..133	CDD:276809	8/34 (24%)
		TPR 2	94..127		6/28 (21%)
		TPR 3	138..173		10/40 (25%)
		TPR repeat	138..168	CDD:276809	8/35 (23%)
		PEP_TPR_lipo	<157..470	CDD:274350	70/344 (20%)
		TPR 4	181..214		6/32 (19%)
		TPR repeat	214..244	CDD:276809	4/29 (14%)
		TPR 5	249..282		6/37 (16%)
		TPR repeat	249..277	CDD:276809	4/27 (15%)
		Interaction with the 5'-triphosphate group of PPP-RNA	254..260		0/5 (0%)
		TPR repeat	282..333	CDD:276809	8/50 (16%)
		TPR 6	338..371		10/33 (30%)
		TPR repeat	338..366	CDD:276809	8/28 (29%)
		TPR 7	376..410		10/33 (30%)
		TPR repeat	376..405	CDD:276809	9/28 (32%)
		TPR 8	435..468		10/37 (27%)
		TPR repeat	435..463	CDD:276809	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810