DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31690 and TTC24

DIOPT Version :9

Sequence 1:NP_995615.2 Gene:CG31690 / 33455 FlyBaseID:FBgn0051690 Length:859 Species:Drosophila melanogaster
Sequence 2:NP_001099139.2 Gene:TTC24 / 164118 HGNCID:32348 Length:582 Species:Homo sapiens


Alignment Length:409 Identity:103/409 - (25%)
Similarity:147/409 - (35%) Gaps:92/409 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   483 GLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGH 547
            ||.|||..|.....:..   |..:|.|..|::.:   |||.|...|:...|          .|||
Human    98 GLELLLRAHPEEKAQGR---RHGDQCFNVALAYH---ALGELPQALAWYHR----------ALGH 146

  Fly   548 RPTMAD---AHFNLGVVHQKQLNFSSAIPCFRRAIEL---RPQLAVAYLNLGTS---LISLGDHR 603
            .....|   |...:|..:|.......|..|.:.|.:.   ..||..|.|.||.:   ::..|.||
Human   147 YQPQGDQGEAWAKMGACYQALGQPELAAHCLQEASQAYAQERQLRAAALALGAAAGCMLKSGRHR 211

  Fly   604 -QEAISVLRTGARL-EGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPL-- 664
             .|.:.||....|| |.|..|....|:      |..|.:.|   .:||....|:...|:||||  
Human   212 VGEVVQVLEKSRRLAERSTERRLLGHL------YNDLGLGY---SQLQLFPLAVEAFLQALPLCW 267

  Fly   665 LPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQP------EQGAAYVTYGQTLARNGSRLA 723
            :|.:|..||. .||.....|.::.||....:.|..|..      |||.::.:....|::.|...|
Human   268 VPGEQATVLR-NLGMAHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKA 331

  Fly   724 EAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDYTLQ-------SC-- 779
            ..:::. .|||.|          .|..:.:.:.....||...||.|...|..|:       .|  
Human   332 ARDNYL-HALQAA----------RDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQK 385

  Fly   780 ------------VADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEA----V 828
                        :||.:|  .|||:..|.....:|..|....|.   |...|..|...:|    .
Human   386 EPDSVRERLVAKLADTVR--TRLAQVGLVQTHTLTSAPGRLQAP---GGASQAEGTPAKAGSSTA 445

  Fly   829 ACYHKAL------ELQPGH 841
            ...|::.      |.:.||
Human   446 GVQHRSSSGWEDEEFEEGH 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31690NP_995615.2 DUF1736 272..340 CDD:285594
TPR_11 518..583 CDD:290150 16/70 (23%)
TPR repeat 518..546 CDD:276809 6/27 (22%)
TPR repeat 551..581 CDD:276809 7/32 (22%)
TPR_1 552..584 CDD:278916 7/37 (19%)
TPR 565..841 CDD:223533 78/322 (24%)
TPR repeat 586..611 CDD:276809 9/28 (32%)
TPR repeat 634..660 CDD:276809 6/25 (24%)
TPR repeat 671..699 CDD:276809 8/27 (30%)
TPR repeat 704..735 CDD:276809 7/30 (23%)
TPR repeat 740..768 CDD:276809 4/27 (15%)
TPR repeat 773..803 CDD:276809 10/50 (20%)
TPR 808..841 CDD:197478 7/42 (17%)
TPR repeat 808..836 CDD:276809 6/37 (16%)
TTC24NP_001099139.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
TPR_12 36..105 CDD:290160 5/6 (83%)
TPR 1 36..69
TPR repeat 36..64 CDD:276809
TPR 2 79..112 6/13 (46%)
TPR_12 80..148 CDD:290160 19/65 (29%)
TPR repeat 81..111 CDD:276809 6/12 (50%)
TPR repeat 116..146 CDD:276809 10/42 (24%)
TPR 3 117..150 12/45 (27%)
TPR_11 121..180 CDD:290150 17/71 (24%)
TPR 4 154..187 6/32 (19%)
TPR repeat 154..180 CDD:276809 5/25 (20%)
TPR_12 232..302 CDD:290160 23/79 (29%)
TPR 5 236..271 13/43 (30%)
TPR repeat 238..264 CDD:276809 8/34 (24%)
TPR_12 271..345 CDD:290160 20/85 (24%)
TPR 6 273..306 9/33 (27%)
TPR 273..302 CDD:197478 8/29 (28%)
TPR repeat 273..301 CDD:276809 8/28 (29%)
TPR repeat 312..342 CDD:276809 7/30 (23%)
TPR 7 313..346 8/43 (19%)
TPR_12 314..385 CDD:290160 16/81 (20%)
TPR 8 353..386 8/32 (25%)
TPR repeat 353..381 CDD:276809 7/27 (26%)
TPR_1 353..>380 CDD:278916 7/26 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..481 11/50 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 548..582
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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