DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and TMTC3

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_861448.2	Gene:	TMTC3 / 160418	HGNCID:	26899	Length:	914	Species:	Homo sapiens

Alignment Length:	906	Identity:	266/906 - (29%)
Similarity:	388/906 - (42%)	Gaps:	200/906 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ATLSHKDLAGLAGCSALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVD 77
            |.::.|::..:.|   :....|.|:|..|||:||..|||.|.|:..:.||..|.:|||||||:.:
Human     2 ANINLKEITLIVG---VVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSE 63

  Fly    78 SGSHGSWRPLCVLSFRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLPSRMGVLAAGALF 142
            ..||.|:|||.||:||||||...:.|:.|||:|::.|.|.:.:...|.:..|.::..|:|: .||
Human    64 ERSHKSYRPLTVLTFRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFLDNKSSVIAS-LLF 127

  Fly   143 AVHPAHTEAVAGLVGRADLASCVCYLLAYLSYRRHM---LNREWGSLILTIMLALAALLCKETAI 204
            ||||.|||||.|:||||:|.|.:.:|.|:|||.|..   .:..|..:.||:.|...|.||||..|
Human   128 AVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRSKGPDNSIIWTPIALTVFLVAVATLCKEQGI 192

  Fly   205 TALLLCGLCDVLSPVGRENSDKVC---------DGSISGLASFNFQRRFRSLSILGFTLLCGLYC 260
            |.:.:|.:.:|....| .....:|         .|||    .|:..:....|.:|.|:.|..:..
Human   193 TVVGICCVYEVFIAQG-YTLPLLCTTAGQFLRGKGSI----PFSMLQTLVKLIVLMFSTLLLVVI 252

  Fly   261 RLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLW 325
            |:.::......|:..|||.| .|...||.|||.||...|..:||.|.||..||.|..:..|.:|.
Human   253 RVQVIQSQLPVFTRFDNPAA-VSPTPTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESLL 316

  Fly   326 DARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQ 390
            |.||:.|..|:                                        |  :||:
Human   317 DIRNLATFTFF----------------------------------------C--FLGM------- 332

  Fly   391 LSAPSYRSASAIYSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPSVGY 455
            |...|.|     ||..| ||:.      ::....:.|||:|||||.|.||||:||||||:||:|:
Human   333 LGVFSIR-----YSGDS-SKTV------LMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGF 385

  Fly   456 CLLFGLGFGHLWQRVNS-SWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINP-- 517
            |:|    ..|.||:::: |...:|..:| |::::..|.::||.||.||..|..||.||:.:|.
Human   386 CIL----VAHGWQKISTKSVFKKLSWIC-LSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNN 445

  Fly   518 PKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLN--------------- 567
            .|...|:|..|..:..:|.|..........:|....||.|:|..: |.||
Human   446 AKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTY-KNLNRTKEAEESYMMAKSL 509

  Fly   568 FSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHR-QEAISVLRTGARLEGSGVRDRGAHVEAR 631
            ....||..:.|..:.|.....|:|| .:||...:.| :||..:.|....:..
Human   510 MPQIIPGKKYAARIAPNHLNVYINL-ANLIRANESRLEEADQLYRQAISMRP------------- 560

  Fly   632 YTCYLQLSVLYRSDG----RLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEH 692
                 .....|.|.|    ::.....|....||||.|  .:..|.|...|..:..||::.|||..
Human   561 -----DFKQAYISRGELLLKMNKPLKAKEAYLKALEL--DRNNADLWYNLAIVHIELKEPNEALK 618

  Fly   693 QQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHH 757
            ....|::|.|:...|.......:..:|......|: .||.|.....||...:.|.:
Human   619 NFNRALELNPKHKLALFNSAIVMQESGEVKLRPEA-RKRLLSYINEEPLDANGYFN--------- 673

  Fly   758 EALGLRLRAAALAPQDYTLQSCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANL-------- 814
              ||:      ||..|              .:..|||:|.:||:.||.....|..||
Human   674 --LGM------LAMDD--------------KKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTA 716

  Fly   815 ---------------------GAILQ---MRGLRKE---AVACYHKALELQPGHAISRANL 848
                                 |.||:   :...:|:   |..|:.:.||:.|.:...:.||
Human   717 KELKALPILEELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNL 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	29/67 (43%)
		TPR_11	518..583	CDD:290150	17/79 (22%)
		TPR repeat	518..546	CDD:276809	6/27 (22%)
		TPR repeat	551..581	CDD:276809	10/44 (23%)
		TPR_1	552..584	CDD:278916	10/46 (22%)
		TPR	565..841	CDD:223533	69/330 (21%)
		TPR repeat	586..611	CDD:276809	8/25 (32%)
		TPR repeat	634..660	CDD:276809	4/29 (14%)
		TPR repeat	671..699	CDD:276809	9/27 (33%)
		TPR repeat	704..735	CDD:276809	6/30 (20%)
		TPR repeat	740..768	CDD:276809	4/27 (15%)
		TPR repeat	773..803	CDD:276809	7/29 (24%)
		TPR	808..841	CDD:197478	12/67 (18%)
		TPR repeat	808..836	CDD:276809	9/62 (15%)
TMTC3	NP_861448.2	DUF1736	259..331	CDD:312047	30/114 (26%)
		TPR 1	412..445		13/32 (41%)
		TPR_11	<435..802	CDD:330823	87/397 (22%)
		TPR 2	446..479		7/32 (22%)
		TPR repeat	446..474	CDD:276809	6/27 (22%)
		TPR repeat	479..523	CDD:276809	10/44 (23%)
		TPR 3	481..513		7/32 (22%)
		TPR 4	528..562		9/52 (17%)
		TPR repeat	530..557	CDD:276809	9/27 (33%)
		TPR repeat	562..592	CDD:276809	8/29 (28%)
		TPR 5	563..596		9/34 (26%)
		TPR repeat	597..625	CDD:276809	9/27 (33%)
		TPR 7	668..701		14/63 (22%)
		TPR repeat	668..696	CDD:276809	12/58 (21%)
		TPR repeat	701..731	CDD:276809	3/29 (10%)
		TPR 8	703..735		3/31 (10%)
		TPR 9	736..770		9/33 (27%)
		TPR repeat	736..765	CDD:276809	6/28 (21%)
		TPR repeat	771..799	CDD:276809	2/7 (29%)
		TPR 10	772..804		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..891
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820