DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31690 and TMTC2

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_689801.1	Gene:	TMTC2 / 160335	HGNCID:	25440	Length:	836	Species:	Homo sapiens

Alignment Length:	854	Identity:	309/854 - (36%)
Similarity:	448/854 - (52%)	Gaps:	68/854 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVLS 91
            |||...||||||:|.|.|||.|||..|.|:....|..::..||||||.|..||||.|:||||.||
Human     8 SALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLS 72

  Fly    92 FRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLPSRMGVLAAGALFAVHPAHTEAVAGLV 156
            ||||:..||:.|..||||||:||...|.|....::.||........||.:||.||.|||||||:|
Human    73 FRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIV 137

  Fly   157 GRADLASCVCYLLAYLSYRRHMLN-----REWGSLILTIMLALAALLCKETAITALLLCGLCDVL 216
            ||||:.:.:.:||:.|.|.:|...     |.||..:.:.:.|..::|.||..:|.|.:..:.||
Human   138 GRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDV- 201

  Fly   217 SPVGRENSDKVCDGSISGLASFNFQR-----------------RFRSLSILGFTLLCGLYCRLSL 264
                                 |.|.|                 .|.|:|:|.|.....|..||..
Human   202 ---------------------FVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLGARLYW 245

  Fly   265 LPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARN 329
            :.....:||.:|||.|......||||||.|||..|..:||.|..|||||.|:||..::|:.|.||
Human   246 MGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRN 310

  Fly   330 ILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQLSAP 394
            :.|..||..|:.:.:.|....|.....:...|.|..    :...|:||      ..|..:|.|..
Human   311 LHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGK----QNANGHSC------LSDVEYQNSET 365

  Fly   395 SYRSASAIYS-----TSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPSVG 454
            ....||.:.:     .|.:::..|.....:|..:.|::||:||:||.||||||:||||||:||:|
Human   366 KSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMG 430

  Fly   455 YCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINPPK 519
            :|||..:|...|:.:|...:...| :....|.|:..:|::|..||.||::||.|:||.|.:||.|
Human   431 FCLLITVGARALYVKVQKRFLKSL-IFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAK 494

  Fly   520 ALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQ 584
            |.||||:||.:|.:..|||...|..|.:|..|||..:|||::.|:...|:.|:..::.||..||.
Human   495 AWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPT 559

  Fly   585 LAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQ 649
            ||.||||.|..|::.| ..:||.......:.:....::|..||..:..:|...|..||...|..:
Human   560 LASAYLNTGIILMNQG-RTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYE 623

  Fly   650 DAAAALRESLKALP--LLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVTYG 712
            :|.:..:|:::.:|  ..||.    |:..:||....|....||||....:::.:.:...|::|||
Human   624 EALSVYKEAIQKMPRQFAPQS----LYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYG 684

  Fly   713 QTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDYTLQ 777
            :.||..| |.:|||..|.:|::|.|.:.:.:.||..||.::.|..||..:..:||.|...::.:.
Human   685 KLLALTG-RKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVV 748

  Fly   778 SCVADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQPGHA 842
            ...|..||..:....||.:|..|..|:|....|..||||||.:.|..::|.|.|.:||:|:|...
Human   749 FNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDV 813

  Fly   843 ISRANLARM 851
            |:::||.::
Human   814 ITQSNLRKL 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	34/67 (51%)
		TPR_11	518..583	CDD:290150	26/64 (41%)
		TPR repeat	518..546	CDD:276809	13/27 (48%)
		TPR repeat	551..581	CDD:276809	11/29 (38%)
		TPR_1	552..584	CDD:278916	11/31 (35%)
		TPR	565..841	CDD:223533	87/277 (31%)
		TPR repeat	586..611	CDD:276809	10/24 (42%)
		TPR repeat	634..660	CDD:276809	7/25 (28%)
		TPR repeat	671..699	CDD:276809	8/27 (30%)
		TPR repeat	704..735	CDD:276809	13/30 (43%)
		TPR repeat	740..768	CDD:276809	8/27 (30%)
		TPR repeat	773..803	CDD:276809	7/29 (24%)
		TPR	808..841	CDD:197478	15/32 (47%)
		TPR repeat	808..836	CDD:276809	12/27 (44%)
TMTC2	NP_689801.1	DUF1736	247..318	CDD:285594	33/70 (47%)
		TPR 1	462..492		13/29 (45%)
		TPR_11	493..554	CDD:290150	24/60 (40%)
		TPR 2	493..526		15/32 (47%)
		TPR repeat	493..521	CDD:276809	13/27 (48%)
		TPR_1	493..>520	CDD:278916	13/26 (50%)
		TPR 3	527..560		12/32 (38%)
		TPR repeat	527..555	CDD:276809	9/27 (33%)
		TPR_12	557..634	CDD:290160	23/77 (30%)
		TPR repeat	560..590	CDD:276809	11/30 (37%)
		TPR 4	562..594		9/32 (28%)
		TPR repeat	595..634	CDD:276809	10/38 (26%)
		TPR 5	606..639		8/32 (25%)
		TPR_2	609..638	CDD:285020	6/28 (21%)
		TPR repeat	642..671	CDD:276809	10/32 (31%)
		TPR 6	643..676		9/36 (25%)
		TPR_11	645..708	CDD:290150	22/63 (35%)
		TPR 7	677..710		15/33 (45%)
		TPR repeat	679..705	CDD:276809	13/26 (50%)
		TPR repeat	710..774	CDD:276809	17/63 (27%)
		TPR 8	712..744		10/31 (32%)
		TPR 9	746..778		9/31 (29%)
		TPR_19	755..822	CDD:291240	26/66 (39%)
		TPR 10	779..812		15/32 (47%)
		TPR_1	779..812	CDD:278916	15/32 (47%)
		TPR repeat	779..807	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3317
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	560	1.000	Inparanoid score	I1100
Isobase	1	0.950	-	0	Normalized mean entropy	S4190
OMA	1	1.010	-	-		QHG52430
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0004694
OrthoInspector	1	1.000	-	-		otm42083
orthoMCL	1	0.900	-	-		OOG6_106232
Panther	1	1.100	-	-	O	PTHR44216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4791
SonicParanoid	1	1.000	-	-		X3302
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820