DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31690 and Bbs4

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_780534.1	Gene:	Bbs4 / 102774	MGIID:	2143311	Length:	520	Species:	Mus musculus

Alignment Length:	406	Identity:	85/406 - (20%)
Similarity:	142/406 - (34%)	Gaps:	93/406 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 LLGVHGVRTFRRNLDWRDEEQLFRSAISINPP--KALGNLGSVLSAQGRYEEAELTLRMTL---G 546
            |||.|...|           :::..|..:|..  :...|||...:...::.:|:..|...|   .
Mouse   113 LLGKHKAAT-----------EVYNEAAKLNQKDWEICHNLGVCYTYLKQFNKAQDQLHSALQLNK 166

  Fly   547 HRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLR 611
            |..|    :..||.:|..|.:...||..:::|:|..|:.......||...:.||.: |:|...|
Mouse   167 HDLT----YIMLGKIHLLQGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGVY-QKAFEHL- 225

  Fly   612 TGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQ--------- 667
                  |:.:    .:..|.|...|....:.::.|....|....|....|:|..|.
Mouse   226 ------GNAL----TYDPANYKAILAAGSMMQTHGDFDVALTKYRVVACAIPESPPLWNNIGMCF 280

  Fly   668 --KQRAVLHL------------------RLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVTYG 712
              |::.|..:                  .||.:...:|.:..|.|....|:..||:.|..|:...
Mouse   281 FGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLA 345

  Fly   713 QTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALG----LRLRAAAL---A 770
            ..|. |...:..|...:..|::|....|..:.:||..|..|.....||.    :..:...|   :
Mouse   346 VALT-NLEDIENARRAYVEAVRLDKCNPLVNLNYAVLLYNQGEKKSALAQYQEMEKKVNFLKDNS 409

  Fly   771 PQDYTLQSC-VADALRLLNRLAEAELWYR---------------KAVTLQPMAAHAHANLGAILQ 819
            |.::..:.. :|..|....::.||.:|.:               |:.|||       ..||:| |
Mouse   410 PLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKTKHRTNSGSKSATLQ-------QPLGSI-Q 466

  Fly   820 MRGLRKEAVACYHKAL 835
            ..|....:.|.|.|.|
Mouse   467 ALGQAMSSAAAYRKIL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	16/69 (23%)
		TPR repeat	518..546	CDD:276809	6/32 (19%)
		TPR repeat	551..581	CDD:276809	7/29 (24%)
		TPR_1	552..584	CDD:278916	8/31 (26%)
		TPR	565..841	CDD:223533	67/323 (21%)
		TPR repeat	586..611	CDD:276809	6/24 (25%)
		TPR repeat	634..660	CDD:276809	4/25 (16%)
		TPR repeat	671..699	CDD:276809	7/45 (16%)
		TPR repeat	704..735	CDD:276809	6/30 (20%)
		TPR repeat	740..768	CDD:276809	7/31 (23%)
		TPR repeat	773..803	CDD:276809	6/45 (13%)
		TPR	808..841	CDD:197478	9/28 (32%)
		TPR repeat	808..836	CDD:276809	9/28 (32%)
Bbs4	NP_780534.1	Required for localization to centrosomes. /evidence=ECO:0000250	1..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		TPR 1	67..100
		TPR repeat	68..95	CDD:276809
		Interaction with PCM1. /evidence=ECO:0000250	101..337		51/250 (20%)
		TPR_11	101..166	CDD:290150	13/63 (21%)
		TPR repeat	101..129	CDD:276809	6/26 (23%)
		TPR repeat	134..164	CDD:276809	6/29 (21%)
		TPR_11	136..199	CDD:290150	16/66 (24%)
		TPR_11	169..233	CDD:290150	18/79 (23%)
		TPR repeat	169..196	CDD:276809	8/30 (27%)
		TPR	170..201	CDD:197478	10/34 (29%)
		TPR repeat	202..229	CDD:276809	8/34 (24%)
		TPR repeat	236..264	CDD:276809	5/27 (19%)
		TPR_11	237..301	CDD:290150	9/63 (14%)
		TPR repeat	270..298	CDD:276809	3/27 (11%)
		TPR_11	272..335	CDD:290150	8/62 (13%)
		TPR repeat	303..333	CDD:276809	6/29 (21%)
		TPR_11	305..369	CDD:290150	15/64 (23%)
		Required for localization to centrosomes. /evidence=ECO:0000250	338..520		34/154 (22%)
		TPR repeat	338..366	CDD:276809	6/28 (21%)
		TPR_16	342..400	CDD:290168	12/58 (21%)
		TPR repeat	372..397	CDD:276809	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..520
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900