DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31690 and tmtc1

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_002942298.2	Gene:	tmtc1 / 100498549	XenbaseID:	XB-GENE-6033540	Length:	1168	Species:	Xenopus tropicalis

Alignment Length:	949	Identity:	293/949 - (30%)
Similarity:	412/949 - (43%)	Gaps:	216/949 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PSMSATLSHKDLAGLAGCSALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGT 73
            || ..:|.|..||..|..:.|.||   .::...||:||..|||.|.|.....||:::..|||||.
Frog   311 PS-GTSLGHWVLALPAILATLCFV---RSVFGEFVHDDVWAILNNPDSRAETPLSSIFGNDFWGK 371

  Fly    74 PLVDSGSHGSWRPLCVLSFRLNYLAGGMTPLGYHLVNVMLH-CVATWLVFLVARTLLPSRMGVLA 137
            .:.|:.||.|:|||||||||:|...||:..:.:|.:|::|| .|::.|:|..:..:...:...||
Frog   372 AMNDNTSHKSYRPLCVLSFRINVFLGGLNAIYFHAINIVLHAAVSSLLMFTCSTAVFEDKRLALA 436

  Fly   138 AGALFAVHPAHTEAVAGLVGRADLASCVCYLLAYLSYRRHMLNREWGS-------------LILT 189
            |..||:.||.|||||||:|||||:.||:.:||.:|||.|.|   :.|.             |:|:
Frog   437 AALLFSAHPIHTEAVAGIVGRADVLSCLLFLLTFLSYIRSM---DSGPPRHSFPPTSAPLFLLLS 498

  Fly   190 IMLALAALLCKETAITALLLCGLCDVL-----------SPVGRENSDKVCDGSISGLASFNFQRR 243
            ::|...|:|.|||.||...:|...|:|           ||..|        .||..:|. .|.:|
Frog   499 LILGTGAVLVKETGITVFGVCLTYDLLLLCPTRCKRYSSPDPR--------ASIWYVAG-PFLKR 554

  Fly   244 FRSLSILGFTLLCGLYCRLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQE 308
            ...:|:  :..|. ||.||.::......||..|||.:......||.||:|||...|..:||.|..
Frog   555 AALVSL--YVALV-LYFRLRIMGGSMPLFSEQDNPASFSPYPLTRFLTYLYLLAFNSWLLLAPIT 616

  Fly   309 LSFDWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLG 373
            |.:||.:.::..|.:|||.||:.|..|.|.:      ||             :|...|..|:|
Frog   617 LCYDWQVGSIPLINSLWDVRNLATLLFVGIV------GS-------------LALHCLAFLKR-- 660

  Fly   374 GNSCHTWLGLTCDCHHQLSAPSYRSASAIYSTSSKSKSASWTAAP----ILGTAFLVLPFLPASN 434
                                                       ||    ::|..|||.||:||||
Frog   661 -------------------------------------------APRREVLVGLLFLVFPFIPASN 682

  Fly   435 LLFYVGFVMAERVLYLPSVGYCLLFGLGF----GHLWQRVNSSWRSRLMLLCGLALLLGVHGVRT 495
            |.|.||||:||||||:||:|:|:|...|.    .|:.||     ||..:.||.|.||| :...::
Frog   683 LFFRVGFVVAERVLYMPSMGFCILCVHGLKVLQSHVGQR-----RSLSLTLCFLFLLL-LFSCKS 741

  Fly   496 FRRNLDWRDEEQLFRSAISINP--PKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNL 558
            ..::..||..|.||||.:...|  .|...|..:.|..|.|.:||.:..:..|...|..:.|..||
Frog   742 LSQSECWRSREALFRSGVQTLPHNAKVHYNYANFLKDQSRKDEAIMHYKTVLRLYPKHSSALNNL 806

  Fly   559 GVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRD 623
            |.:   ..|.:.|...:|||:.:.||.:.|..|||..|.:.|.. .||..:||..... ||...|
Frog   807 GTL---TANTTEAEEYYRRALMISPQHSRALFNLGNLLRNKGQD-DEAELLLRESLHY-GSYFGD 866

  Fly   624 RGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWN 688
                      .|..|..|.....|.::|....:..:|:.|     :.:.||...|..|.:::...
Frog   867 ----------AYSSLGSLLADQKRYEEADDVYQTGIKSCP-----ENSDLHNNYGVFLVDMEKSQ 916

  Fly   689 EAEHQQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQL-----------APLEPSS 742
            :||.....|:.|:|:...|.:..|: |.|:..:..|||.|:::|||:           |.|..:.
Frog   917 KAESHYLHALHLRPDHHVAMLNLGR-LYRSLGQNKEAEKWYRKALQISREADVISPLGALLYNTG 980

  Fly   743 HHHYADFLEQQE----------------------RHHEALGLRLRAAALAPQ------------- 772
            .|..|..|.|:.                      :.|||..|....||..|.
Frog   981 QHEEARRLYQEAVGLHPRNIQIRLSLAQVLAVLGQIHEAEALAYGIAAEVPDCTECFRLLSAIYS 1045

  Fly   773 ------------DYTLQSCVADA-------------LRLLNRLAEAELWYRKAVTLQPMAAHAHA 812
                        |:.||....||             ||.||.|.||...|.:...|.|..|.|..
Frog  1046 KREDYVKALELIDFALQMKSNDAKLLSELHFTRGNQLRELNHLEEAFQSYERVAELNPTQAQAWM 1110

  Fly   813 NLGAILQMRGLRKEAVACYHKALELQPGHAISRANLARM 851
            |:|.|..|:|....|.|.|.||..|.|...:.:.|||::
Frog  1111 NMGGIRHMQGDYTSARAFYQKAAVLDPDSKLLKENLAKL 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	28/67 (42%)
		TPR_11	518..583	CDD:290150	18/64 (28%)
		TPR repeat	518..546	CDD:276809	7/27 (26%)
		TPR repeat	551..581	CDD:276809	9/29 (31%)
		TPR_1	552..584	CDD:278916	9/31 (29%)
		TPR	565..841	CDD:223533	89/346 (26%)
		TPR repeat	586..611	CDD:276809	8/24 (33%)
		TPR repeat	634..660	CDD:276809	5/25 (20%)
		TPR repeat	671..699	CDD:276809	7/27 (26%)
		TPR repeat	704..735	CDD:276809	10/30 (33%)
		TPR repeat	740..768	CDD:276809	8/49 (16%)
		TPR repeat	773..803	CDD:276809	13/42 (31%)
		TPR	808..841	CDD:197478	14/32 (44%)
		TPR repeat	808..836	CDD:276809	12/27 (44%)
tmtc1	XP_002942298.2	DUF1736	574..648	CDD:285594	28/79 (35%)
		TPR_11	765..828	CDD:290150	18/65 (28%)
		TPR repeat	766..794	CDD:276809	7/27 (26%)
		TPR repeat	799..826	CDD:276809	9/29 (31%)
		TPR_17	819..851	CDD:290167	12/32 (38%)
		TPR repeat	831..858	CDD:276809	10/27 (37%)
		TPR	844..1148	CDD:223533	79/321 (25%)
		TPR repeat	866..893	CDD:276809	6/36 (17%)
		TPR repeat	898..928	CDD:276809	7/29 (24%)
		TPR repeat	933..961	CDD:276809	9/28 (32%)
		TPR_8	935..965	CDD:289924	11/30 (37%)
		TPR repeat	966..993	CDD:276809	6/26 (23%)
		TPR_14	972..1009	CDD:290164	6/36 (17%)
		TPR repeat	999..1030	CDD:276809	6/30 (20%)
		TPR repeat	1035..1062	CDD:276809	1/26 (4%)
		TPR repeat	1067..1101	CDD:276809	10/33 (30%)
		TPR_2	1073..1104	CDD:285020	9/30 (30%)
		TPR_1	1106..1138	CDD:278916	13/31 (42%)
		TPR repeat	1106..1132	CDD:276809	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920