DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and tmtc4

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001121486.1	Gene:	tmtc4 / 100158586	XenbaseID:	XB-GENE-5771787	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	794	Identity:	238/794 - (29%)
Similarity:	360/794 - (45%)	Gaps:	163/794 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 AGC--SALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRP 86
            |.|  ..||||.:.|:.|..||:||..||:.|.|:.|..|:|:|..:|||||.|..:.||.|:||
Frog    21 AKCLVGTLAFVCFANSYNGRFVFDDSEAIINNKDLRGETPVADLWLHDFWGTKLSSNASHKSYRP 85

  Fly    87 LCVLSFRLNY-LAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLP----SRMG---------VLA 137
            |.||:||:|| :|||:.|:|:|.||::|||:.:.|:..|...|..    |..|         .|.
Frog    86 LTVLTFRMNYHIAGGLHPVGFHFVNIVLHCLVSVLMLNVFSMLFGGMTCSHKGKQITYAPKASLL 150

  Fly   138 AGALFAVHPAHTEAVAGLVGRADLASCVCYLLAYLSYRRHMLNRE-------WGSLILTIMLALA 195
            |..||||||.|||.|||:||||||...:|.:|::|.|.|.:....       |  ::.:|:||..
Frog   151 AALLFAVHPVHTECVAGIVGRADLLCALCVVLSFLGYCRALPGNNTTHSSVFW--VMFSILLAAV 213

  Fly   196 ALLCKETAITAL---------LLCGLCDVLSPVGRE-NSDKVCDGSISGLASFNFQRR--FRSLS 248
            |:||||..||.|         ::|.| ::|..|.:. ..||..:.:       .|.|:  |..:|
Frog   214 AMLCKEQGITVLGLNAVFDVFVICKL-NILECVQKVLRRDKTSENN-------KFDRKGLFVRIS 270

  Fly   249 ILGFTLLCGLYCRLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDW 313
            :|....:|.||.|..::.....||:..|||.:.......|.:.:.|....|..:||.|..|.|||
Frog   271 LLVSGGICMLYIRWRIMGTGPPAFTEVDNPASFADSLLVRVINYNYYYSLNGWLLLCPWWLCFDW 335

  Fly   314 GMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCH 378
            .|..:..|.:|.|.|.|.....:..|:.::::
Frog   336 SMGCIPLINSLSDWRVIALVALWFCLLGLMYQ--------------------------------- 367

  Fly   379 TWLGLTCDCHHQLSAPSYRSASAIYSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVM 443
                                  |::|.:::.:...     .||..||::||||||||.|.||||:
Frog   368 ----------------------ALFSNNAQKRRML-----TLGLGFLIIPFLPASNLFFRVGFVV 405

  Fly   444 AERVLYLPSVGYCLLFGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQL 508
            |||||||||||||:||..|:..:.:.:    :::.:|...:..::.::.||...|:..|:.||.|
Frog   406 AERVLYLPSVGYCVLFTYGYSKICRLI----KNKKLLSAAILGIMVMNVVRCIYRSNQWKSEELL 466

  Fly   509 FRSAISINP---------------------------------PK---ALGNLGSVLSAQGRYEEA 537
            ||||||:.|                                 ||   |:.|||::|..:.:.:||
Frog   467 FRSAISVCPLNAKVHYNVGKNLADRGYQTEAIEFYRESVRLNPKYVHAMNNLGNILKEKDQLQEA 531

  Fly   538 ELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDH 602
            :..|...:..:|..|.|..|||:|......|..|...:..||:.|.:....|.|||.....|..|
Frog   532 QQLLSRAVSIQPDFAAAWMNLGIVQNSLKYFEEAEKSYLTAIKYRKKYPDCYYNLGRLYADLNRH 596

  Fly   603 RQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQ 667
             .:|::..|....|       :..|..|    :..:.:|..:.|.|..|.|..||:||.||
Frog   597 -VDALNAWRNATFL-------KPEHSLA----WNNMIILMDNTGNLAKAEAIGREALKLLP---- 645

  Fly   668 KQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRA 732
             ....:...|..:|.:.|.:.|:|.....|::..| ..|:|......|......|..|:..::.:
Frog   646 -NDHSITFSLANVLGKAQKYKESESLFLKAIEANP-SSASYHNNLAVLYHRWGNLDLAKKHYEIS 708

  Fly   733 LQLAPLEPSSHHHY 746
            ::|.|..|.:..:|
Frog   709 MKLDPSAPGTKENY 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	20/67 (30%)
		TPR_11	518..583	CDD:290150	21/67 (31%)
		TPR repeat	518..546	CDD:276809	10/30 (33%)
		TPR repeat	551..581	CDD:276809	10/29 (34%)
		TPR_1	552..584	CDD:278916	11/31 (35%)
		TPR	565..841	CDD:223533	43/182 (24%)
		TPR repeat	586..611	CDD:276809	7/24 (29%)
		TPR repeat	634..660	CDD:276809	7/25 (28%)
		TPR repeat	671..699	CDD:276809	6/27 (22%)
		TPR repeat	704..735	CDD:276809	5/30 (17%)
		TPR repeat	740..768	CDD:276809	2/7 (29%)
		TPR repeat	773..803	CDD:276809
		TPR	808..841	CDD:197478
		TPR repeat	808..836	CDD:276809
tmtc4	NP_001121486.1	DUF1736	288..362	CDD:369859	21/73 (29%)
		TPR	423..708	CDD:223533	72/306 (24%)
		TPR repeat	478..506	CDD:276809	0/27 (0%)
		TPR repeat	514..540	CDD:276809	8/25 (32%)
		TPR repeat	545..575	CDD:276809	10/29 (34%)
		TPR repeat	580..606	CDD:276809	8/26 (31%)
		TPR repeat	614..642	CDD:276809	8/31 (26%)
		TPR repeat	647..677	CDD:276809	6/29 (21%)
		TPR repeat	682..710	CDD:276809	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7022
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010