DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31690 and tmtc2

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001096156.1	Gene:	tmtc2 / 100124656	XenbaseID:	XB-GENE-948541	Length:	836	Species:	Xenopus tropicalis

Alignment Length:	846	Identity:	318/846 - (37%)
Similarity:	462/846 - (54%)	Gaps:	52/846 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVLS 91
            |||..|||||||.|.|.|||.|||..|.|:....|..::..||||||.|..||||.|:||||.||
Frog     8 SALGLVLYLNTLGADFCYDDSRAIKTNQDLLPETPWNHIFFNDFWGTLLTHSGSHKSYRPLCTLS 72

  Fly    92 FRLNYLAGGMTPLGYHLVNVMLHCVATWLVFLVARTLLPSRMGVLAAGALFAVHPAHTEAVAGLV 156
            ||||||.||:.|..|||||::||...|.|...:.:.|..|....|.||.|||.||.|||||||:|
Frog    73 FRLNYLLGGLDPWSYHLVNILLHSAVTGLFTNLCKALFGSGCWTLIAGLLFASHPIHTEAVAGIV 137

  Fly   157 GRADLASCVCYLLAYLSYRRHMLNR-----EWGSLILTIMLALAALLCKETAITALLLCGLCDVL 216
            ||||:.:.:.:||:.|.|.:|...|     .|..::.....|..::|.||..:|.|.:..:.|:.
Frog   138 GRADVGAGLFFLLSLLCYMKHCSTRGYSLSSWCWILCAGFWAACSMLWKEQGVTVLAVSAVYDIF 202

  Fly   217 SPVGRENSDKVCDGSISGLASFNFQRR----FRSLSIL---GFTLLCGLYCRLSLLPRPSTAFSA 274
            .      ..|:   .::.:.|..|:|:    |.|:.:|   |..|| |:  |...:.....:||.
Frog   203 V------FHKL---KMNQIISVVFKRKNVSFFFSVGLLFAWGVVLL-GV--RFYWMGNTPPSFSN 255

  Fly   275 ADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARNILTAGFYGSL 339
            :|||.|......||||||.|||..|..:|..|..|||||.|:||..|:|:.|.|||.|..|:  :
Frog   256 SDNPAADCEVLLTRTLTFFYLPTKNLWLLFCPDTLSFDWSMDAVPLIKTIIDWRNIHTVAFH--I 318

  Fly   340 VAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTC--DCHHQLSAPSYRSASAI 402
            :.||...|.|:.:|...|    .|      .:|..|..|...|.:|  |..|:.:......||.:
Frog   319 LLILLSYSSLKGSAMKRD----CN------GKLFMNGKHNTNGHSCQSDLEHKNAEQKPVIASKL 373

  Fly   403 -----YSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPSVGYCLLFGLG 462
                 :..|.:.:..|.....:|..:.|::||:|||||.||||||:||||||:||:|:|||..:|
Frog   374 ENGIKHHISHEMQLPSTKNIVVLALSLLIVPFVPASNLFFYVGFVIAERVLYIPSMGFCLLVTVG 438

  Fly   463 FGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINPPKALGNLGSV 527
            ...|:.:...::...|:.....||:: .:|::|..||.||::||.|:||.|.:||.||.||||:|
Frog   439 ARALYIKAQKNFLKSLLFYATTALIV-FYGLKTVVRNGDWKNEEMLYRSGIKVNPAKAWGNLGNV 502

  Fly   528 LSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNL 592
            |.:|.:.:|||...|..|.:|..|||..:|||::.|:...||.|:..::.||..||.||..|||.
Frog   503 LKSQSKIDEAENAYRNALYYRSNMADMLYNLGLLLQENSKFSEALHYYKLAIGSRPTLASGYLNT 567

  Fly   593 GTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRE 657
            |..|::.| ..:||.......:.:....::|..||..:..:|...|..||...|:.:||....:|
Frog   568 GIILMNQG-RTEEARRTFLKCSEIPDENLKDPNAHKSSVTSCLYNLGKLYHEQGQYEDALIVYKE 631

  Fly   658 SLKALP--LLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVTYGQTLARNGS 720
            :::.:|  ..||.    |:..:||....|...:||||....:::.:|:...|::|||:.|...|
Frog   632 AIQKMPRQFSPQS----LYNMMGEAYMRLNLVSEAEHWYTESLKSKPDHIPAHLTYGKLLTLTG- 691

  Fly   721 RLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDYTLQSCVADALR 785
            |..|||.:|.:|:||.|.:.:.:.||..||.::.|..||..:..:||.|...::.:....|..||
Frog   692 RKNEAERYFLKAIQLDPNKGNCYMHYGQFLLEEGRLLEAAEMAKKAAELDNSEFDVVFNAAHMLR 756

  Fly   786 LLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQPGHAISRANLAR 850
            ..:....||.:|:.|..|:|....|..||||||.:.|..:||.:.|.:||:|:|..||:::||.:
Frog   757 QASLNEAAEKYYKLAAGLRPNYPAALMNLGAILHLNGKLEEAESNYLRALQLKPDDAITQSNLRK 821

  Fly   851 M 851
            :
Frog   822 L 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	34/67 (51%)
		TPR_11	518..583	CDD:290150	27/64 (42%)
		TPR repeat	518..546	CDD:276809	13/27 (48%)
		TPR repeat	551..581	CDD:276809	12/29 (41%)
		TPR_1	552..584	CDD:278916	12/31 (39%)
		TPR	565..841	CDD:223533	89/277 (32%)
		TPR repeat	586..611	CDD:276809	9/24 (38%)
		TPR repeat	634..660	CDD:276809	8/25 (32%)
		TPR repeat	671..699	CDD:276809	8/27 (30%)
		TPR repeat	704..735	CDD:276809	12/30 (40%)
		TPR repeat	740..768	CDD:276809	8/27 (30%)
		TPR repeat	773..803	CDD:276809	7/29 (24%)
		TPR	808..841	CDD:197478	15/32 (47%)
		TPR repeat	808..836	CDD:276809	12/27 (44%)
tmtc2	NP_001096156.1	PMT_2	43..244	CDD:389829	84/212 (40%)
		DUF1736	247..316	CDD:369859	33/68 (49%)
		PEP_TPR_lipo	<461..821	CDD:274350	131/366 (36%)
		TPR repeat	493..521	CDD:276809	13/27 (48%)
		TPR repeat	526..556	CDD:276809	12/29 (41%)
		TPR repeat	561..589	CDD:276809	9/28 (32%)
		TPR repeat	601..634	CDD:276809	9/32 (28%)
		TPR repeat	642..671	CDD:276809	10/32 (31%)
		TPR repeat	676..706	CDD:276809	12/30 (40%)
		TPR repeat	779..807	CDD:276809	12/27 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3092
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1027
OMA	1	1.010	-	-		QHG52430
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0004694
OrthoInspector	1	1.000	-	-		oto105237
Panther	1	1.100	-	-	O	PTHR44216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3302
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080