DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf4 and TBP

DIOPT Version :9

Sequence 1:	NP_608699.1	Gene:	Trf4 / 33452	FlyBaseID:	FBgn0031444	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_003185.1	Gene:	TBP / 6908	HGNCID:	11588	Length:	339	Species:	Homo sapiens

Alignment Length:	261	Identity:	54/261 - (20%)
Similarity:	96/261 - (36%)	Gaps:	42/261 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EGTSAKLSSLDKLFEELKISKESSAKEDLVTEPMKTESYLYKDYFN-KSPIDFPWEKAYEKGSSL 94
            :|||.:   ..:||.          .:.|.|.|:...:.||..... .:||. |...|.| .|.:
Human   112 QGTSGQ---APQLFH----------SQTLTTAPLPGTTPLYPSPMTPMTPIT-PATPASE-SSGI 161

  Fly    95 GPDFYIDYENIFDNVANLAEIEEKLELHFRPFTCVMDFNCRFSMYELCLLLAESRFDPSSHPSVV 159
            .|..    :||...|                     :..|:..:..:.|....:.::|....:|:
Human   162 VPQL----QNIVSTV---------------------NLGCKLDLKTIALRARNAEYNPKRFAAVI 201

  Fly   160 VKITHPSAQVKIHAGGKISST-ALNADSARSGLFKVIRILQDLDYKVDIMNFSKNIVNASFSMPF 223
            ::|..|.....|.:.||:..| |.:.:.:|....|..|::|.|.:....::|....:..|..:.|
Human   202 MRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKF 266

  Fly   224 KIDLDLMSRRHVVEVAQNRSRRPFITYTTENLGVRFAVFPTGFVLVLHSTSHCETREAIANFLPI 288
            .|.|:.:...|....:......|.:.|......:...:|.:|.|::..:....|..||..|..||
Human   267 PIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPI 331

  Fly   289 L 289
            |
Human   332 L 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4	NP_608699.1	TBP	128..200	CDD:278767	14/72 (19%)
		PLN00062	131..294	CDD:177693	34/160 (21%)
		TBP	213..291	CDD:278767	17/77 (22%)
TBP	NP_003185.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		polyglutamine repeat	58..95
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..159		10/33 (30%)
		PLN00062	162..338	CDD:177693	38/196 (19%)
		Repetitive region	165..241		17/100 (17%)
		Repetitive region	255..332		15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.905639	Normalized mean entropy	S205
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10126
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860