DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf4 and Tbp

DIOPT Version :9

Sequence 1:	NP_608699.1	Gene:	Trf4 / 33452	FlyBaseID:	FBgn0031444	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_038712.3	Gene:	Tbp / 21374	MGIID:	101838	Length:	316	Species:	Mus musculus

Alignment Length:	235	Identity:	49/235 - (20%)
Similarity:	88/235 - (37%)	Gaps:	29/235 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EDLVTEPMKTESYLYKDYFN-KSPIDFPWEKAYEKGSSLGPDFYIDYENIFDNVANLAEIEEKLE 120
            :.|.|.|:...:.||..... .:||. |...|.| .|.:.|..    :||...|
Mouse   102 QTLTTAPLPGTTPLYPSPMTPMTPIT-PATPASE-SSGIVPQL----QNIVSTV----------- 149

  Fly   121 LHFRPFTCVMDFNCRFSMYELCLLLAESRFDPSSHPSVVVKITHPSAQVKIHAGGKISST-ALNA 184
                      :..|:..:..:.|....:.::|....:|:::|..|.....|.:.||:..| |.:.
Mouse   150 ----------NLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSE 204

  Fly   185 DSARSGLFKVIRILQDLDYKVDIMNFSKNIVNASFSMPFKIDLDLMSRRHVVEVAQNRSRRPFIT 249
            :.:|....|..|::|.|.:....::|....:..|..:.|.|.|:.:...|....:......|.:.
Mouse   205 EQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLI 269

  Fly   250 YTTENLGVRFAVFPTGFVLVLHSTSHCETREAIANFLPIL 289
            |......:...:|.:|.|::..:....|..||..|..|||
Mouse   270 YRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPIL 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4	NP_608699.1	TBP	128..200	CDD:278767	14/72 (19%)
		PLN00062	131..294	CDD:177693	34/160 (21%)
		TBP	213..291	CDD:278767	17/77 (22%)
Tbp	NP_038712.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..135		10/32 (31%)
		PLN00062	139..315	CDD:177693	38/196 (19%)
		TBP_eukaryotes	139..312	CDD:239952	38/196 (19%)
		Repetitive region	142..218		17/100 (17%)
		Repetitive region	232..309		15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.905639	Normalized mean entropy	S205
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10126
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860