DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta4R2 and PSMB8

DIOPT Version :9

Sequence 1:	NP_001259950.1	Gene:	Prosbeta4R2 / 33451	FlyBaseID:	FBgn0031443	Length:	210	Species:	Drosophila melanogaster
Sequence 2:	NP_683720.2	Gene:	PSMB8 / 5696	HGNCID:	9545	Length:	276	Species:	Homo sapiens

Alignment Length:	197	Identity:	40/197 - (20%)
Similarity:	81/197 - (41%)	Gaps:	3/197 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TILGIKGPDFVMLASDTMQAKSLVFMKDDQSKIHRLSDFNMMATVGDGGDTIQFTDFISKNLHLY 69
            |.|..|....|:.|.|:..:..........:|:..::.:.:....|...|...:...::|...||
Human    74 TTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLY 138

  Fly    70 KISHGYHLSAKSAAHFTRKTLADYIRTNTRYQVAMLLAGYDAVEGPDLHYIDSYGAAQSINHAGH 134
            .:.:|..:|..:|:......:..|  ......:..::.|:|. :||.|:|:|.:|...|.|....
Human   139 YLRNGERISVSAASKLLSNMMCQY--RGMGLSMGSMICGWDK-KGPGLYYVDEHGTRLSGNMFST 200

  Fly   135 GWGSMFCGSILQRYWNSKLSQEDAYSLMKKCVLEIQRRLIINQRNFEVYVVDSKGMRKMEAINPG 199
            |.|:.:...::...:...||.|:||.|.::.:.....|...:.....:|.:...|..|:|:.:..
Human   201 GSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVS 265

  Fly   200 SL 201
            .|
Human   266 DL 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta4R2	NP_001259950.1	PRE1	1..194	CDD:223711	38/188 (20%)
Prosbeta4R2	NP_001259950.1	proteasome_beta_type_2	3..194	CDD:239727	38/188 (20%)
PSMB8	NP_683720.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
PSMB8	NP_683720.2	proteasome_beta_type_5	73..260	CDD:239730	38/188 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810