DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta4R2 and PSMB2

DIOPT Version :9

Sequence 1:	NP_001259950.1	Gene:	Prosbeta4R2 / 33451	FlyBaseID:	FBgn0031443	Length:	210	Species:	Drosophila melanogaster
Sequence 2:	NP_002785.1	Gene:	PSMB2 / 5690	HGNCID:	9539	Length:	201	Species:	Homo sapiens

Alignment Length:	195	Identity:	86/195 - (44%)
Similarity:	133/195 - (68%)	Gaps:	0/195 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 METILGIKGPDFVMLASDTMQAKSLVFMKDDQSKIHRLSDFNMMATVGDGGDTIQFTDFISKNLH 67
            ||.::||:|||:|::|||.:.|.::|.||||..|:.::|:..::..||:.|||:||.::|.||:.
Human     1 MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQ 65

  Fly    68 LYKISHGYHLSAKSAAHFTRKTLADYIRTNTRYQVAMLLAGYDAVEGPDLHYIDSYGAAQSINHA 132
            |||:.:||.||..:||:|||:.|||.:|:.|.|.|.:||||||..|||.|:|:|...|......|
Human    66 LYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFA 130

  Fly   133 GHGWGSMFCGSILQRYWNSKLSQEDAYSLMKKCVLEIQRRLIINQRNFEVYVVDSKGMRKMEAIN 197
            .||:|:....|||.||:...:|:|.|..|::||:.|:|:|.|:|...|.|.::|..|:..::.|:
Human   131 AHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNIS 195

Fly 198 197
Human 196 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta4R2	NP_001259950.1	PRE1	1..194	CDD:223711	85/190 (45%)
Prosbeta4R2	NP_001259950.1	proteasome_beta_type_2	3..194	CDD:239727	85/190 (45%)
PSMB2	NP_002785.1	proteasome_beta_type_2	1..192	CDD:239727	85/190 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147325
Domainoid	1	1.000	200	1.000	Domainoid score	I3035
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3566
Isobase	1	0.950	-	0	Normalized mean entropy	S587
OMA	1	1.010	-	-		QHG53714
OrthoDB	1	1.010	-	-		D1392180at2759
OrthoFinder	1	1.000	-	-		FOG0002770
OrthoInspector	1	1.000	-	-		otm40860
orthoMCL	1	0.900	-	-		OOG6_102061
Panther	1	1.100	-	-	O	PTHR11599
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1860
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720