DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosbeta4R2 and pbs-4

DIOPT Version :9

Sequence 1:	NP_001259950.1	Gene:	Prosbeta4R2 / 33451	FlyBaseID:	FBgn0031443	Length:	210	Species:	Drosophila melanogaster
Sequence 2:	NP_491261.1	Gene:	pbs-4 / 171975	WormBaseID:	WBGene00003950	Length:	202	Species:	Caenorhabditis elegans

Alignment Length:	205	Identity:	60/205 - (29%)
Similarity:	108/205 - (52%)	Gaps:	19/205 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 METILGIKGPDFVMLASDTMQ-AKSLVFMKDDQSKIHRLSDFNMMATVGDGGDTIQFTDFISKNL 66
            |..::||...::|:||:|... |...:....:..|.:||.....|..:|:.||..||.|:..:||
Worm     4 MHFLVGISTENYVILAADKATFAYGAILADSENDKEYRLGKKLTMMCIGEEGDVAQFGDWTKRNL 68

  Fly    67 HLYKISHGYHLSAKSAAHFTRKTLADYIRTNTRYQVAMLLAGYDAVEGPDLHYIDSYGAAQSINH 131
            .||.:.:||.:|...|.||.|:::|:.:|:...|.|.:|:.|||..|  |..::.      |:::
Worm    69 QLYSVRNGYEVSPSCAHHFVRRSIAEGLRSQDHYTVDVLIGGYDDKE--DKAFLG------SVDY 125

  Fly   132 AGHGWGSM----------FCGSILQRYWNSKLSQEDAYSLMKKCVLEIQRRLIINQRNFEVYVVD 186
            ..:|.|..          ||.:|:.|.:...:::.:..:||.||:.|.:||.:.|...::|.::|
Worm   126 LANGLGQQPYLFRGFCGRFCYAIMDREYKKDMTEAEGLALMNKCIGEAKRRFVANIPGYKVVIID 190

  Fly   187 SKGMRKMEAI 196
            .||.||::.:
Worm   191 KKGYRKLDDV 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosbeta4R2	NP_001259950.1	PRE1	1..194	CDD:223711	60/201 (30%)
Prosbeta4R2	NP_001259950.1	proteasome_beta_type_2	3..194	CDD:239727	60/201 (30%)
pbs-4	NP_491261.1	proteasome_beta_type_2	4..199	CDD:239727	60/202 (30%)
pbs-4	NP_491261.1	PRE1	8..199	CDD:223711	59/198 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159441
Domainoid	1	1.000	118	1.000	Domainoid score	I3643
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I3187
Isobase	1	0.950	-	0	Normalized mean entropy	S587
OMA	1	1.010	-	-		QHG53714
OrthoDB	1	1.010	-	-		D1392180at2759
OrthoFinder	1	1.000	-	-		FOG0002770
OrthoInspector	1	1.000	-	-		otm14204
orthoMCL	1	0.900	-	-		OOG6_102061
Panther	1	1.100	-	-	O	PTHR11599
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1860
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.760