Protein Alignment CG9962 and VRK2

DIOPT Version :10

• Sequence 1: NP_608697.1
• Gene: CG9962 / 33448
• FlyBaseID: FBgn0031441
• Length: 319
• Species: Drosophila melanogaster
• Sequence 2: NP_006287.2
• Gene: VRK2 / 7444
• HGNCID: 12719
• Length: 508
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 101/353 - (28%)
• Similarity: 169/353 - (47%)
• Gaps: 62/353 - (17%)

  Fly    13 NSIMVIRKLGSGSFGDIY----------EAKH-----------MGSGLHVALKVERKNAGQSHLS 56
            |..::.:|:|||.||.||          :|:|           :.|.|....:|.:|:..:..:.
Human    27 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCIKKWIE 91

  Fly    57 IESTVYNLLRHGMGIPMTY----QFFSNRRHDVLVMELLGPSLETLFTMCNRRFSMKTVLMLADQ 117
            .:...|      :|||:.|    ..|..|.:..:|||.||..|:.:... |..|...|||.|..:
Human    92 RKQLDY------LGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKSTVLQLGIR 149

  Fly   118 MVDRLEYLHLHHYVHRDIKPENFLMGVGLTRHRLHLIDFGLSKRY---WDMKENRHVPQRRGTKW 179
            |:|.|||:|.:.|||.|||..|.|:|. ....:::|.|:|||.||   .:.|:.:..| |:|..
Human   150 MLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQYQENP-RKGHN- 211

  Fly   180 AGTARYASVNALCCKVQSRRDDLESVGYVLIYLLRGSLPW-QGLLPNSKLQKAEMILEMKLSTLP 243
             ||..:.|::|......|||.|:|.:||.::..|.|.||| |.|.....:|.|:..|   |..||
Human   212 -GTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNL---LDELP 272

  Fly   244 NSLCAGYPN-----EFYNYIIYTRQLGFEEEPDYRMIRCTFLS--------LLFNLKFTNDLIYD 295
            .|:....|:     |...:::....|.::|:|:|:.:: ..|:        |.|:.|..:..::.
Human   273 QSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALK-KILNPHGIPLGPLDFSTKGQSINVHT 336

  Fly   296 WDHAEKNSGKSGSEE-----DRVVVKKV 318
            .:..:.:|.|:.:::     :|::.|||
Human   337 PNSQKVDSQKAATKQVNKAHNRLIEKKV 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9962	NP_608697.1	STKc_CK1	17..279	CDD:270918	90/295 (31%)
VRK2	NP_006287.2	STKc_VRK2	16..314	CDD:271025	91/301 (30%)
		Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393	397..508