Protein Alignment Drp1 and MGM1

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_014854.2
• Gene: MGM1 / 854386
• SGDID: S000005737
• Length: 881
• Species: Saccharomyces cerevisiae
• Alignment Length: 740
• Identity: 175/740 - (23%)
• Similarity: 305/740 - (41%)
• Gaps: 213/740 - (28%)

  Fly    10 KLQDVFNTVGSDS--IQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIYSPL 72
            :::.:.|.|.|.|  :.||.|||:||||||||||:||:|||.|||:|:.:|||||:.|.|:.:|
Yeast   193 EIRTILNKVDSSSAHLTLPSIVVIGSQSSGKSSVLESIVGREFLPKGSNMVTRRPIELTLVNTP- 256

  Fly    73 DDRENRSAENGTSNAEEWGRFLHTKKCFTDFDEIRKEIENETERAAGSNKGICPEPINLKIFSTH 137
                  ::.|.|::.... |..:.|    ||.|:::.: .|...|..:::.:..|||.|.|.|:.
Yeast   257 ------NSNNVTADFPSM-RLYNIK----DFKEVKRML-MELNMAVPTSEAVSEEPIQLTIKSSR 309

  Fly   138 VVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATSEALKLAKDV 202
            |.:|:||||||..:|...|||.:::.:|::|..||:..|| ||||::||:.|:|.|.|||.:|..
Yeast   310 VPDLSLVDLPGYIQVEAADQPIELKTKIRDLCEKYLTAPN-IILAISAADVDLANSSALKASKAA 373

  Fly   203 DPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHIDDQMKDEAAF 267
            ||.|.||:.|:|||||:|. ..|..||..:..|:.:|.:||:.::...| ::||:.  :..||.
Yeast   374 DPKGLRTIGVITKLDLVDP-EKARSILNNKKYPLSMGYVGVITKTPSSI-NRKHLG--LFGEAP- 433

  Fly   268 LQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSYGEDVSDKSQT- 331
                             :.:|:.:...                        ..:|:...:::..
Yeast   434 -----------------SSSLSGIFSK------------------------GQHGQSSGEENTNG 457

  Fly   332 LLQIIT-KFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHPLAGLSKMDILTAI 395
            |.||:: :|..||                         |.|                .....|..
Yeast   458 LKQIVSHQFEKAY-------------------------FKE----------------NKKYFTNC 481

  Fly   396 RNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGNEVQQEMLRFPKLH 460
            :.:|                     ::|.|..::.:|:   .|...::.....:|||:
Yeast   482 QVST---------------------KKLREKLIKILEI---SMSNALEPTSTLIQQEL------- 515

  Fly   461 EKIVDVVTQLLR-----RRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLKTDSDP--- 517
                |..:.|.:     |.|...:.::.||..::|. |......||::.  :.|:|:.:.|.
Yeast   516 ----DDTSYLFKVEFNDRHLTPKSYLLNNIDVLKLG-IKEFQEKFHRNE--LKSILRAELDQKVL 573

  Fly   518 -------YSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQV-----HEQ 570
                   :...||                                |..||.:..|..     |::
Yeast   574 DVLATRYWKDDNL--------------------------------QDLSSSKLESDTDMLYWHKK 606

  Fly   571 NHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRL 635
            ..:|.:....|....||.:|.......: ::|...:|.:.|:        .|:.|:.:|.....|
Yeast   607 LELASSGLTKMGIGRLSTMLTTNAILKE-LDNILESTQLKNH--------ELIKDLVSNTAINVL 662

  Fly   636 TDKEQKDCDVIEHLIKSYFYIVRKSIQD-SVPKAIMHFLVNYVKDNLQS-----ELVTHLYKSDK 694
            ..|.....|.:|:.||.:.|.:....:| |:.:   ...:|.:|:.|:.     :.:.:...|.|
Yeast   663 NSKYYSTADQVENCIKPFKYEIDLEERDWSLAR---QHSINLIKEELRQCNSRYQAIKNAVGSKK 724

  Fly   695 AETLLNESDHIAVRRKEAADMLKAL 719
            ...::...::.:..:||...|.|.|
Yeast   725 LANVMGYLENESNLQKETLGMSKLL 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	103/277 (37%)
		Dynamin_M	224..507	CDD:460033	41/289 (14%)
		GED	639..729	CDD:460495	17/87 (20%)
MGM1	NP_014854.2	DLP_1	208..468	CDD:206738	108/319 (34%)