DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and VPS1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_012926.1	Gene:	VPS1 / 853870	SGDID:	S000001709	Length:	704	Species:	Saccharomyces cerevisiae

Alignment Length:	777	Identity:	317/777 - (40%)
Similarity:	432/777 - (55%)	Gaps:	124/777 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EALIPVINKLQDVFNTVGSDS---IQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPL 63
            |.||..||||||....:|..|   |.||||.|:||||||||||:|::|||.||||||||||||||
Yeast     3 EHLISTINKLQDALAPLGGGSQSPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPL 67

  Fly    64 VLQLIYS--------------------PLDDRENRSAENG--------TSNAEEWGRFLHTK-KC 99
            |||||..                    .::|.:.:..|:|        ..|.||||.|||.. |.
Yeast    68 VLQLINRRPKKSEHAKVNQTANELIDLNINDDDKKKDESGKHQNEGQSEDNKEEWGEFLHLPGKK 132

  Fly   100 FTDFDEIRKEIENETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQ 164
            |.:||||||||..||::..|:|.||...||||:|:|.||:.||||||||:|||||||||.|||.|
Yeast   133 FYNFDEIRKEIVKETDKVTGANSGISSVPINLRIYSPHVLTLTLVDLPGLTKVPVGDQPPDIERQ 197

  Fly   165 IKELVLKYIENPNSIILAVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDIL 229
            ||:::||||..||:|||:|.|||||:|.|:.||||::|||:|.||:.|:||:||||.|||.||||
Yeast   198 IKDMLLKYISKPNAIILSVNAANTDLANSDGLKLAREVDPEGTRTIGVLTKVDLMDQGTDVIDIL 262

  Fly   230 CGRVIPVKLGIIGVMNRSQKDIMDQKHIDDQMKDEAAFLQR--KYPTLATRNGTPYLAKTLNRLL 292
            .|||||::.|.|.|:||.||||..:|.|.:.:::|..|.:.  .|.:.|...|||||||.||.:|
Yeast   263 AGRVIPLRYGYIPVINRGQKDIEHKKTIREALENERKFFENHPSYSSKAHYCGTPYLAKKLNSIL 327

  Fly   293 MHHIRDCLPDLKTRVNIMATQFQSLLNSYGEDVSDK-SQTLLQIITKFSSAYCCTIEGTARNIET 356
            :||||..||::|.::.....::|:.|.:.|.:..|. |..:|.:||.||:.|...::|.|:.:.:
Yeast   328 LHHIRQTLPEIKAKIEATLKKYQNELINLGPETMDSASSVVLSMITDFSNEYAGILDGEAKELSS 392

  Fly   357 TELCGGARMGYIFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIR 421
            .||.||||:.|:|||||...:||:.|...:...||.|.:.|::|..|:|||...:||:|||:|||
Yeast   393 QELSGGARISYVFHETFKNGVDSLDPFDQIKDSDIRTIMYNSSGSAPSLFVGTEAFEVLVKQQIR 457

  Fly   422 RLEEPSLRCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIV 486
            |.||||||.|.|:.:|:.|:::...:  |.:..|:|.|.|.|.:...|.|:.....||..|.:|:
Yeast   458 RFEEPSLRLVTLVFDELVRMLKQIIS--QPKYSRYPALREAISNQFIQFLKDATIPTNEFVVDII 520

  Fly   487 AIELAYINTKHPDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQ 551
            ..|..||||.|||          |||                                |||....
Yeast   521 KAEQTYINTAHPD----------LLK--------------------------------GSQAMVM 543

  Fly   552 QQPPQPNSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIEN-------------- 602
            .:           .::|.:....:..|..           |.||:|.|.:.
Yeast   544 VE-----------EKLHPRQVAVDPKTGK-----------PLPTQPSSSKAPVMEEKSGFFGGFF 586

  Fly   603 STNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPK 667
            ||.|......:.||         .|......::|::|..:.:||:.||.|||.||:::|.|.:||
Yeast   587 STKNKKKLAALESP---------PPVLKATGQMTERETMETEVIKLLISSYFSIVKRTIADIIPK 642

  Fly   668 AIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEI 729
            |:|..|:...|.::|..|:..||.....|.|..|:|....||||...|::.|..|:.|:|.:
Yeast   643 ALMLKLIVKSKTDIQKVLLEKLYGKQDIEELTKENDITIQRRKECKKMVEILRNASQIVSSV 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	172/308 (56%)
		CrfC	88..728	CDD:223771	262/657 (40%)
		Dynamin_M	226..507	CDD:279383	117/283 (41%)
		GED	643..729	CDD:280391	34/85 (40%)
VPS1	NP_012926.1	DLP_1	27..336	CDD:206738	172/308 (56%)
		Dynamin_M	258..541	CDD:395818	123/326 (38%)
		GED	616..704	CDD:396682	34/87 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53558
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		otm46867
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2093
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.810