DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and FZO1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_009738.1	Gene:	FZO1 / 852477	SGDID:	S000000383	Length:	855	Species:	Saccharomyces cerevisiae

Alignment Length:	603	Identity:	106/603 - (17%)
Similarity:	199/603 - (33%)	Gaps:	219/603 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 IKELVLK------YIENPNSIILAVTAANTDMATSEALKLAKDVDPDG-------------RRTL 210
            :|..:||      .::..|:|.....|||.:......|:|  ::..||             ::.|
Yeast    99 LKRSILKTQAFMDQLQEENNIRPIFIAANDEREKLHVLQL--NIKLDGQYNTKEKNGFNIEKKAL 161

  Fly   211 AVVTKLDLMDAGTDAIDILCGRV--IPVKLGIIGVMNRSQ----KDIMDQKHI-DDQMKDEAAFL 268
            :.:....::.. |:.::.|..||  :..|:.|.|.:|..:    ..::.|:.: :||:.....|.
Yeast   162 SKLFHSQIVSV-TNHLNALKKRVDDVSSKVFITGDVNTGKSALCNSLLKQRLLPEDQLPCTNVFS 225

  Fly   269 Q----RKYPTLATRNGTPY-LAKTLNRLL------------MHHIRDCLPDLKTRVNIMATQFQS 316
            :    |:...:...:..|. :|.||...:            :|.::: ||||     :......:
Yeast   226 EILEARENDGIEEVHAIPLNIAPTLKEAIDMYSIQNPKTYEIHTLKE-LPDL-----VPQNGKYA 284

  Fly   317 LLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIH 381
            ||..|.:|  ||...                        :|.|.....:.....::.|..:||:.
Yeast   285 LLKIYIKD--DKRPA------------------------STSLLRNGTVDISLIDSPGLNMDSLQ 323

  Fly   382 PLAGLSK---MDILTAIRNATGPRPALFVPEVSFELLVKRQ-------IRRLEE--PSLRCVELI 434
            ....:|:   :|::..:.||..   .|.:....|..|..|:       :::.::  ...||.|||
Yeast   324 TAEVMSRQEEIDLVIFVVNAEN---QLTLSAKEFISLASREKKLMFFVVKKFDKIRDKQRCKELI 385

  Fly   435 HEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRR--RLPHTNVMVENIVAIELAYINTKH 497
            .::::.:              .|:.:::..|.|..:.:.  .|||              |.|...
Yeast   386 LKQIRDL--------------SPETYKRAADFVHFVSKNGDELPH--------------YHNEND 422

  Fly   498 PDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQ 562
            .:.|.|.       |.|.||||                                ...|.|:.
Yeast   423 NEDHGDR-------KPDDDPYS--------------------------------SSDPDPDF--- 445

  Fly   563 QYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPV-----NL 622
                                               ||:|:|..|..:....:|.:.|.     .|
Yeast   446 -----------------------------------DSLEDSLRNFVLKKRSLSKLLPAKTYLSKL 475

  Fly   623 LPDV--PANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSEL 685
            |.|:  .:..|.:..:::|.|..:.:|.|        |..|..:  :|..:.|...| |.:..:.
Yeast   476 LSDIIMISKSNMKMYSEEEIKINEQLETL--------RPEILSA--RAKCNDLTTSV-DQMAEQT 529

  Fly   686 VTHLYKSDKAETLLNESD 703
            :|..|.:.| |.|||..|
Yeast   530 ITMTYNNTK-EALLNALD 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	31/178 (17%)
		CrfC	88..728	CDD:223771	106/603 (18%)
		Dynamin_M	226..507	CDD:279383	55/318 (17%)
		GED	643..729	CDD:280391	16/61 (26%)
FZO1	NP_009738.1	CrfC	128..841	CDD:223771	98/574 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900