DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and DNM1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_013100.1	Gene:	DNM1 / 850686	SGDID:	S000003924	Length:	757	Species:	Saccharomyces cerevisiae

Alignment Length:	795	Identity:	347/795 - (43%)
Similarity:	487/795 - (61%)	Gaps:	108/795 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            :|.|||.:||||||....|.|::.||.:.|:|||||||||::|::|||.||||||||||||||||
Yeast     4 LEDLIPTVNKLQDVMYDSGIDTLDLPILAVVGSQSSGKSSILETLVGRDFLPRGTGIVTRRPLVL 68

  Fly    66 QL----IYSPLDDRENRSA------------ENGT----------SNAEEWGRFLHTK-KCFTDF 103
            ||    ..|||.:.::.|.            |.||          ::|:|||.|||.. |.|.||
Yeast    69 QLNNISPNSPLIEEDDNSVNPHDEVTKISGFEAGTKPLEYRGKERNHADEWGEFLHIPGKRFYDF 133

  Fly   104 DEIRKEIENETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKEL 168
            |:|::||||||.|.||.:|||...|||||:||.||:||||||||||||||:|:||.|||.|||.|
Yeast   134 DDIKREIENETARIAGKDKGISKIPINLKVFSPHVLNLTLVDLPGITKVPIGEQPPDIEKQIKNL 198

  Fly   169 VLKYIENPNSIILAVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRV 233
            :|.||..||.:||||:.||.|:..||:||||::|||.|:||:.|:|||||||:||:|:|||.|::
Yeast   199 ILDYIATPNCLILAVSPANVDLVNSESLKLAREVDPQGKRTIGVITKLDLMDSGTNALDILSGKM 263

  Fly   234 IPVKLGIIGVMNRSQKDIMDQKHIDDQM-KDEAAFLQRKYP---TLATRNGTPYLAKTLNRLLMH 294
            .|:|||.:||:||||:||...|.:::.: |:|..|  ||:|   |::|:.||.||||.||:.|:.
Yeast   264 YPLKLGFVGVVNRSQQDIQLNKTVEESLDKEEDYF--RKHPVYRTISTKCGTRYLAKLLNQTLLS 326

  Fly   295 HIRDCLPDLKTRVNIMATQFQSLLNSYG----EDVSDKSQTLLQIITKFSSAYCCTIEGTARNIE 355
            ||||.|||:||::|.:.:|.:..|..||    .....::..:||::.|||:.:..:|:||:.:|.
Yeast   327 HIRDKLPDIKTKLNTLISQTEQELARYGGVGATTNESRASLVLQLMNKFSTNFISSIDGTSSDIN 391

  Fly   356 TTELCGGARMGYIFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQI 420
            |.|||||||:.||::..||.:|.||.|.:.||.:|:.|||||:|||||.|||||::|:||||.||
Yeast   392 TKELCGGARIYYIYNNVFGNSLKSIDPTSNLSVLDVRTAIRNSTGPRPTLFVPELAFDLLVKPQI 456

  Fly   421 RRLEEPSLRCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENI 485
            :.|.|||.|||||::||:.:|...||:   .|:.|:|||...:::|:::|||.||..|...||::
Yeast   457 KLLLEPSQRCVELVYEELMKICHKCGS---AELARYPKLKSMLIEVISELLRERLQPTRSYVESL 518

  Fly   486 VAIELAYINTKHPDFHKDAALVPSLLKTD--------SDPYSQINLGQRRANTPRNHMSPQISSH 542
            :.|..|||||.||:|......:..::||.        ....||...||.......:.:|..|...
Yeast   519 IDIHRAYINTNHPNFLSATEAMDDIMKTRRKRNQELLKSKLSQQENGQTNGINGTSSISSNIDQD 583

  Fly   543 S------------AGSQQPQ---------QQQPPQP--NSSQQQYSQVHEQNHVAENSTPSMAST 584
            |            |.|:|.:         :.:..||  ::|.::.|...:.| :.:.....::..
Yeast   584 SAKNSDYDDDGIDAESKQTKDKFLNYFFGKDKKGQPVFDASDKKRSIAGDGN-IEDFRNLQISDF 647

  Fly   585 WLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHL 649
            .|.:|        |.:||:                     :.|       ||::|:.:|::|:.|
Yeast   648 SLGDI--------DDLENA---------------------EPP-------LTEREELECELIKRL 676

  Fly   650 IKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAAD 714
            |.|||.|:|:.|:|.||||:|..||||.||::|:.|||.|||....|.||.|...:|..|:....
Yeast   677 IVSYFDIIREMIEDQVPKAVMCLLVNYCKDSVQNRLVTKLYKETLFEELLVEDQTLAQDRELCVK 741

  Fly   715 MLKALTRANHIISEI 729
            .|....:|..:||.|
Yeast   742 SLGVYKKAATLISNI 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	172/308 (56%)
		CrfC	88..728	CDD:223771	291/679 (43%)
		Dynamin_M	226..507	CDD:279383	135/288 (47%)
		GED	643..729	CDD:280391	39/85 (46%)
DNM1	NP_013100.1	DLP_1	26..333	CDD:206738	172/308 (56%)
		Dynamin_M	255..540	CDD:395818	136/289 (47%)
		GED	665..756	CDD:128597	40/90 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346554
Domainoid	1	1.000	264	1.000	Domainoid score	I299
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6384
Inparanoid	1	1.050	586	1.000	Inparanoid score	I140
Isobase	1	0.950	-	0	Normalized mean entropy	S470
OMA	1	1.010	-	-		QHG53558
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		otm46867
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2093
SonicParanoid	1	1.000	-	-		X2114
TreeFam	1	0.960	-	-
	16	15.740