Protein Alignment Drp1 and DNM1

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_013100.1
• Gene: DNM1 / 850686
• SGDID: S000003924
• Length: 757
• Species: Saccharomyces cerevisiae
• Alignment Length: 795
• Identity: 347/795 - (43%)
• Similarity: 487/795 - (61%)
• Gaps: 108/795 - (13%)

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            :|.|||.:||||||....|.|::.||.:.|:|||||||||::|::|||.||||||||||||||||
Yeast     4 LEDLIPTVNKLQDVMYDSGIDTLDLPILAVVGSQSSGKSSILETLVGRDFLPRGTGIVTRRPLVL 68

  Fly    66 QL----IYSPLDDRENRSA------------ENGT----------SNAEEWGRFLHTK-KCFTDF 103
            ||    ..|||.:.::.|.            |.||          ::|:|||.|||.. |.|.||
Yeast    69 QLNNISPNSPLIEEDDNSVNPHDEVTKISGFEAGTKPLEYRGKERNHADEWGEFLHIPGKRFYDF 133

  Fly   104 DEIRKEIENETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKEL 168
            |:|::||||||.|.||.:|||...|||||:||.||:||||||||||||||:|:||.|||.|||.|
Yeast   134 DDIKREIENETARIAGKDKGISKIPINLKVFSPHVLNLTLVDLPGITKVPIGEQPPDIEKQIKNL 198

  Fly   169 VLKYIENPNSIILAVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRV 233
            :|.||..||.:||||:.||.|:..||:||||::|||.|:||:.|:|||||||:||:|:|||.|::
Yeast   199 ILDYIATPNCLILAVSPANVDLVNSESLKLAREVDPQGKRTIGVITKLDLMDSGTNALDILSGKM 263

  Fly   234 IPVKLGIIGVMNRSQKDIMDQKHIDDQM-KDEAAFLQRKYP---TLATRNGTPYLAKTLNRLLMH 294
            .|:|||.:||:||||:||...|.:::.: |:|..|  ||:|   |::|:.||.||||.||:.|:.
Yeast   264 YPLKLGFVGVVNRSQQDIQLNKTVEESLDKEEDYF--RKHPVYRTISTKCGTRYLAKLLNQTLLS 326

  Fly   295 HIRDCLPDLKTRVNIMATQFQSLLNSYG----EDVSDKSQTLLQIITKFSSAYCCTIEGTARNIE 355
            ||||.|||:||::|.:.:|.:..|..||    .....::..:||::.|||:.:..:|:||:.:|.
Yeast   327 HIRDKLPDIKTKLNTLISQTEQELARYGGVGATTNESRASLVLQLMNKFSTNFISSIDGTSSDIN 391

  Fly   356 TTELCGGARMGYIFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQI 420
            |.|||||||:.||::..||.:|.||.|.:.||.:|:.|||||:|||||.|||||::|:||||.||
Yeast   392 TKELCGGARIYYIYNNVFGNSLKSIDPTSNLSVLDVRTAIRNSTGPRPTLFVPELAFDLLVKPQI 456

  Fly   421 RRLEEPSLRCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENI 485
            :.|.|||.|||||::||:.:|...||:   .|:.|:|||...:::|:::|||.||..|...||::
Yeast   457 KLLLEPSQRCVELVYEELMKICHKCGS---AELARYPKLKSMLIEVISELLRERLQPTRSYVESL 518

  Fly   486 VAIELAYINTKHPDFHKDAALVPSLLKTD--------SDPYSQINLGQRRANTPRNHMSPQISSH 542
            :.|..|||||.||:|......:..::||.        ....||...||.......:.:|..|...
Yeast   519 IDIHRAYINTNHPNFLSATEAMDDIMKTRRKRNQELLKSKLSQQENGQTNGINGTSSISSNIDQD 583

  Fly   543 S------------AGSQQPQ---------QQQPPQP--NSSQQQYSQVHEQNHVAENSTPSMAST 584
            |            |.|:|.:         :.:..||  ::|.::.|...:.| :.:.....::..
Yeast   584 SAKNSDYDDDGIDAESKQTKDKFLNYFFGKDKKGQPVFDASDKKRSIAGDGN-IEDFRNLQISDF 647

  Fly   585 WLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHL 649
            .|.:|        |.:||:                     :.|       ||::|:.:|::|:.|
Yeast   648 SLGDI--------DDLENA---------------------EPP-------LTEREELECELIKRL 676

  Fly   650 IKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAAD 714
            |.|||.|:|:.|:|.||||:|..||||.||::|:.|||.|||....|.||.|...:|..|:....
Yeast   677 IVSYFDIIREMIEDQVPKAVMCLLVNYCKDSVQNRLVTKLYKETLFEELLVEDQTLAQDRELCVK 741

  Fly   715 MLKALTRANHIISEI 729
            .|....:|..:||.|
Yeast   742 SLGVYKKAATLISNI 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	172/308 (56%)
		Dynamin_M	224..507	CDD:460033	136/290 (47%)
		GED	639..729	CDD:460495	40/89 (45%)
DNM1	NP_013100.1	DLP_1	26..333	CDD:206738	172/308 (56%)
		Dynamin_M	254..540	CDD:460033	136/290 (47%)
		GED	665..756	CDD:128597	40/90 (44%)