DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and DL1C

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_172936.1	Gene:	DL1C / 838048	AraportID:	AT1G14830	Length:	614	Species:	Arabidopsis thaliana

Alignment Length:	747	Identity:	224/747 - (29%)
Similarity:	345/747 - (46%)	Gaps:	157/747 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQ-------LPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIV 58
            |::||.:|||:|.....:|....:       ||.:.|:|.||||||||:||||||.|||||:|||
plant     4 MKSLIGLINKIQRACTVLGDHGGEGMSLWEALPTVAVVGGQSSGKSSVLESVVGRDFLPRGSGIV 68

  Fly    59 TRRPLVLQLIYSPLDDRENRSAENGTSNAEEWGRFLHT-KKCFTDFDEIRKEIENETERAAGSNK 122
            |||||||||          ...|:||:   |:..|||. ||.|.||..:|||||:||:|..|.:|
plant    69 TRRPLVLQL----------HKTEDGTT---EYAEFLHAPKKRFADFAAVRKEIEDETDRITGKSK 120

  Fly   123 GICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAAN 187
            .|...||.|.|:|.:||||||:||||:|||.|..|||.|...|:.:|..|:|.||.||||::.||
plant   121 QISNIPIQLSIYSPNVVNLTLIDLPGLTKVAVDGQPESIVQDIENMVRSYVEKPNCIILAISPAN 185

  Fly   188 TDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIM 252
            .|:|||:|:|||::|||.|.||..|.||||:||.|||.:|:|.||...::...:|::||||.||
plant   186 QDIATSDAIKLAREVDPTGERTFGVATKLDIMDKGTDCLDVLEGRSYRLQHPWVGIVNRSQADI- 249

  Fly   253 DQKHID---DQMKDEAAF-LQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQ 313
             .|.:|   .:.|::..| ...:|..||:|.|:.||||.|::.|...||..:|.:...:|....:
plant   250 -NKRVDMIAARRKEQEYFETSPEYGHLASRMGSEYLAKLLSQHLETVIRQKIPSIVALINKSIDE 313

  Fly   314 FQSLLNSYGEDVSDKS----QTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFG 374
            ..:.|:..|..::..|    .|:|::...|...:...::|...        ||.|:..:|.....
plant   314 INAELDRIGRPIAVDSGAQLYTILELCRAFDRVFKEHLDGGRP--------GGDRIYGVFDHQLP 370

  Fly   375 RTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQ 439
            ..|..:.....||..::...:..|.|.:|.|..||..:..|:...|...:.|:...|:.:|..::
plant   371 AALKKLPFDRHLSTKNVQKVVSEADGYQPHLIAPEQGYRRLIDGSISYFKGPAEATVDAVHFVLK 435

  Fly   440 RIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDA 504
            .:|:...:|. :|:.|||.|...|.....:.|.|....:...|..:|.:|.:|:..   :|.:
plant   436 ELVRKSISET-EELKRFPTLASDIAAAANEALERFRDESRKTVLRLVDMESSYLTV---EFFR-- 494

  Fly   505 ALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHE 569
                                       :.|:.|:       .::|..:..|.||:..      :.
plant   495 ---------------------------KLHLEPE-------KEKPNPRNAPAPNADP------YS 519

  Fly   570 QNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRR 634
            .||                           .....:|...:.|:|
plant   520 DNH---------------------------FRKIGSNVSAYINMV-------------------- 537

  Fly   635 LTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAE--T 697
                    ||               ::::|:|||:::..|...|.:|.:.....:.:.:|.:  .
plant   538 --------CD---------------TLRNSLPKAVVYCQVREAKRSLLNFFYAQVGRKEKEKLGA 579

  Fly   698 LLNESDHIAVRRKEAADMLKALTRANHIISEI 729
            :|:|...:..||...|..|:...:|...|..:
plant   580 MLDEDPQLMERRGTLAKRLELYKQARDDIDAV 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	145/289 (50%)
		CrfC	88..728	CDD:223771	178/650 (27%)
		Dynamin_M	226..507	CDD:279383	70/288 (24%)
		GED	643..729	CDD:280391	18/87 (21%)
DL1C	NP_172936.1	DLP_1	35..301	CDD:206738	145/280 (52%)
		Dynamin_M	224..488	CDD:395818	68/274 (25%)
		GED	522..611	CDD:396682	22/158 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264244at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780