DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and DRP3A

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001190906.1	Gene:	DRP3A / 829506	AraportID:	AT4G33650	Length:	809	Species:	Arabidopsis thaliana

Alignment Length:	767	Identity:	322/767 - (41%)
Similarity:	458/767 - (59%)	Gaps:	85/767 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ALIPVINKLQDVFNTVGSDS-IQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQ 66
            ::||::|||||:|..:||.| |.|||:||:||||||||||:|::|||.|||||..|.||||||||
plant    36 SVIPIVNKLQDIFAQLGSQSTIALPQVVVVGSQSSGKSSVLEALVGRDFLPRGNDICTRRPLVLQ 100

  Fly    67 LIYSPLDDRENRSAENGTSNAEEWGRFLHTKKC-FTDFDEIRKEIENETERAAGSNKGICPEPIN 130
            |:       :.:|..||.|: :|||.|.|..:. |.||.|||:|||.||.|..|.|||:....|.
plant   101 LL-------QTKSRANGGSD-DEWGEFRHLPETRFYDFSEIRREIEAETNRLVGENKGVADTQIR 157

  Fly   131 LKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATSEA 195
            |||.|.:|:|:|||||||||||||||||.||||:|:.::|.||:....:|||||.||||:|.|:|
plant   158 LKISSPNVLNITLVDLPGITKVPVGDQPSDIEARIRTMILSYIKQDTCLILAVTPANTDLANSDA 222

  Fly   196 LKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHIDDQ 260
            |::|..|||||.||:.|:||||:||.||||..:|.|.|:|::||.:||:||.|:||:..:.:.:.
plant   223 LQIASIVDPDGHRTIGVITKLDIMDKGTDARKLLLGNVVPLRLGYVGVVNRCQEDILLNRTVKEA 287

  Fly   261 MKDEAAFLQRKYPT---LATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVN--IMATQFQSLLNS 320
            :..|..|. |.:|.   ||.|.|.|.|||.||::|:.||:..|||||:|::  ::||..:.  .|
plant   288 LLAEEKFF-RSHPVYHGLADRLGVPQLAKKLNQILVQHIKVLLPDLKSRISNALVATAKEH--QS 349

  Fly   321 YGEDVSDKS---QTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
            |||....::   ..||..::|:..||...:||.:..:.|:||.||||:.|||...|.::|:.:.|
plant   350 YGELTESRAGQGALLLNFLSKYCEAYSSLLEGKSEEMSTSELSGGARIHYIFQSIFVKSLEEVDP 414

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            ...|:..||.|||:||||||.|||||:|.||:||:|||.||.:|||:|...|.||:.:|...|
plant   415 CEDLTDDDIRTAIQNATGPRSALFVPDVPFEVLVRRQISRLLDPSLQCARFIFEELIKISHRC-- 477

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLK 512
             :..|:.|||.|.:::.:|:...||..|..:..|:.:|:.:|:.||||.||:|
plant   478 -MMNELQRFPVLRKRMDEVIGDFLREGLEPSEAMIGDIIDMEMDYINTSHPNF------------ 529

  Fly   513 TDSDPYSQINLGQRRANTPRNHMSPQISS----HSAGSQQPQQQQPPQPNSSQQQYSQ------- 566
                      :|..:|.....|   |:.|    |.....:....:|.:.:||..|...
plant   530 ----------IGGTKAVEAAMH---QVKSSRIPHPVARPKQDTVEPDRTSSSTSQVKSRSFLGRQ 581

  Fly   567 ----VHEQNHV---AENSTPSMAST---W-LSNILPPAPTR---PDSIENSTNNTPV----HNNI 613
                |.:|..|   ||.:.|:..::   | :.:|.....||   .||:.|...:..|    ||
plant   582 ANGIVTDQGVVSADAEKAQPAANASDTRWGIPSIFRGGDTRAVTKDSLLNKPFSEAVEDMSHN-- 644

  Fly   614 VSPVKPVNLLPDVPANHNPRRL-TDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYV 677
            :|.:    .|.:.||...|... :::|..:..:.:.|::||:.||||:|:|||||||||||||:.
plant   645 LSMI----YLKEPPAVLRPTETHSEQEAVEIQITKLLLRSYYDIVRKNIEDSVPKAIMHFLVNHT 705

  Fly   678 KDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEI 729
            |..|.:..:..||:.:..|.:|.|.|.|||:||...:.|..|.:|...:.|:
plant   706 KRELHNVFIKKLYRENLFEEMLQEPDEIAVKRKRTQETLHVLQQAYRTLDEL 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	154/281 (55%)
		CrfC	88..728	CDD:223771	271/678 (40%)
		Dynamin_M	226..507	CDD:279383	117/288 (41%)
		GED	643..729	CDD:280391	37/85 (44%)
DRP3A	NP_001190906.1	DLP_1	57..330	CDD:206738	154/281 (55%)
		Dynamin_M	252..537	CDD:395818	120/312 (38%)
		GED	670..757	CDD:396682	37/86 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	219	1.000	Domainoid score	I726
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	536	1.000	Inparanoid score	I269
OMA	1	1.010	-	-		QHG53558
OrthoDB	1	1.010	-	-		D264244at2759
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		otm3280
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2114
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840