DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and DL1B

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_191735.2	Gene:	DL1B / 825349	AraportID:	AT3G61760	Length:	610	Species:	Arabidopsis thaliana

Alignment Length:	750	Identity:	216/750 - (28%)
Similarity:	333/750 - (44%)	Gaps:	165/750 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGS-----------DSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRG 54
            ||:||.::||:|.....:|.           ||  ||.|.|:|.||||||||:|||||:.|||||
plant     1 MESLIALVNKIQRACTALGDHGEGSSLPTLWDS--LPAIAVVGGQSSGKSSVLESVVGKDFLPRG 63

  Fly    55 TGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWGRFLH-TKKCFTDFDEIRKEIENETERAA 118
            .||||||||||||              :.....:|:..|:| .||.||||..:|:||.:||:|..
plant    64 AGIVTRRPLVLQL--------------HRIDEGKEYAEFMHLPKKKFTDFAAVRQEISDETDRET 114

  Fly   119 G-SNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILA 182
            | |:|.|...||:|.|||.:|||||||||||:|||.|..|||.|...|:.:|..:||.||.||||
plant   115 GRSSKVISTVPIHLSIFSPNVVNLTLVDLPGLTKVAVDGQPESIVQDIENMVRSFIEKPNCIILA 179

  Fly   183 VTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRS 247
            ::.||.|:|||:|:|::::|||.|.||..|:||:||||.||:|:|||.||...::...:||:|||
plant   180 ISPANQDLATSDAIKISREVDPKGDRTFGVLTKIDLMDQGTNAVDILEGRGYKLRYPWVGVVNRS 244

  Fly   248 QKDIMDQKHIDDQMKDEAAFLQR--KYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIM 310
            |.||.....:....:.|..:.|.  :|..|..|.|:.||.|.|::.|...|:..:|.|::.:...
plant   245 QADINKSVDMIAARRRERDYFQTSPEYRHLTERMGSEYLGKMLSKHLEVVIKSRIPGLQSLITKT 309

  Fly   311 ATQFQSLLNSYGE----DVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHE 371
            .::.::.|:..|:    |...|...:::|...|...:...::||.        .||.::..:|..
plant   310 ISELETELSRLGKPVAADAGGKLYMIMEICRAFDQTFKEHLDGTR--------SGGEKINSVFDN 366

  Fly   372 TFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHE 436
            .|...:..:.....||..::...|..|.|.:|.|..||..:..|::..:..:..|:...|:.:|.
plant   367 QFPAAIKRLQFDKHLSMDNVRKLITEADGYQPHLIAPEQGYRRLIESCLVSIRGPAEAAVDAVHS 431

  Fly   437 EMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFH 501
            .::.::.....|. .|:.::|.|..::.......|.|....:......:|.:|..|:..:.  |.
plant   432 ILKDLIHKSMGET-SELKQYPTLRVEVSGAAVDSLDRMRDESRKATLLLVDMESGYLTVEF--FR 493

  Fly   502 KDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQ 566
            |                                                     .|..|::..:.
plant   494 K-----------------------------------------------------LPQDSEKGGNP 505

  Fly   567 VHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHN 631
            .|                              ||.:..|:..:
plant   506 TH------------------------------SIFDRYNDAYL---------------------- 518

  Fly   632 PRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSD--K 694
             ||:...           :.||..:|...:::|:||:|::..|...|.:|.....|.|.:.:  |
plant   519 -RRIGSN-----------VLSYVNMVCAGLRNSIPKSIVYCQVREAKRSLLDIFFTELGQKEMSK 571

  Fly   695 AETLLNESDHIAVRRKEAADMLKALTRANHIISEI 729
            ...||:|...:..||...|..|:....|...|..:
plant   572 LSKLLDEDPAVQQRRTSIAKRLELYRSAQTDIEAV 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	138/281 (49%)
		CrfC	88..728	CDD:223771	171/649 (26%)
		Dynamin_M	226..507	CDD:279383	63/286 (22%)
		GED	643..729	CDD:280391	22/87 (25%)
DL1B	NP_191735.2	DLP_1	33..300	CDD:206738	139/282 (49%)
		Dynamin_M	222..500	CDD:395818	65/341 (19%)
		GED	513..606	CDD:128597	25/126 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264244at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780