DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and DL1E

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_567094.1	Gene:	DL1E / 825189	AraportID:	AT3G60190	Length:	624	Species:	Arabidopsis thaliana

Alignment Length:	752	Identity:	226/752 - (30%)
Similarity:	350/752 - (46%)	Gaps:	158/752 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQ-------DVFNTVGSDSIQ-----LPQIVVLGSQSSGKSSVIESVVGRSFLPR 53
            ||:||.::|::|       |.....||::..     ||.:.|:|.||||||||:||:|||.||||
plant     4 MESLIGLVNRIQRACTVLGDYGGGTGSNAFNSLWEALPTVAVVGGQSSGKSSVLESIVGRDFLPR 68

  Fly    54 GTGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWGRFLH-TKKCFTDFDEIRKEIENETERA 117
            |:||||||||||||          ...::||   ||:..||| .||.||||..:|:||::||:|.
plant    69 GSGIVTRRPLVLQL----------HKTDDGT---EEYAEFLHLPKKQFTDFALVRREIQDETDRI 120

  Fly   118 AGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILA 182
            .|.||.|.|.||:|.|:|.:||||||:||||:|||.|..|||.|...|:.:|..|::.||.||||
plant   121 TGKNKQISPVPIHLSIYSPNVVNLTLIDLPGLTKVAVEGQPETIAEDIESMVRTYVDKPNCIILA 185

  Fly   183 VTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRS 247
            ::.||.|:|||:|:||||||||.|.||..|:|||||||.||:|:::|.||...::...:|::|||
plant   186 ISPANQDIATSDAIKLAKDVDPTGERTFGVLTKLDLMDKGTNALEVLEGRSYRLQHPWVGIVNRS 250

  Fly   248 QKDIMDQKHIDDQM---KDEAAF-LQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVN 308
            |.||  .|::|..:   |:...| ....|..||::.|:.||||.|::.|...||..:|.:.:.:|
plant   251 QADI--NKNVDMMLARRKEREYFDTSPDYGHLASKMGSEYLAKLLSKHLESVIRTRIPSILSLIN 313

  Fly   309 IMATQFQSLLNSYGE----DVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIF 369
            ....:.:..|:..|.    |...:..|:|::...|...:...::|...        ||.|:..:|
plant   314 KSIEELERELDRMGRPVAVDAGAQLYTILEMCRAFDKIFKEHLDGGRP--------GGDRIYGVF 370

  Fly   370 HETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELI 434
            .......|..:.....||...:...:..|.|.:|.|..||..:..|::..:.....|:...|:.:
plant   371 DNQLPAALKKLPFDRHLSLQSVKKIVSEADGYQPHLIAPEQGYRRLIEGALGYFRGPAEASVDAV 435

  Fly   435 HEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPD 499
            |..::.:|:...:|. :|:.|||.|..::.......|.:....:...|..:|.:|.||:..:.
plant   436 HYVLKELVRKSISET-EELKRFPSLQVELAAAANSSLEKFREESKKSVIRLVDMESAYLTAEF-- 497

  Fly   500 FHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQY 564
            |.|                                             .||:.:.|..||..|
plant   498 FRK---------------------------------------------LPQEIERPVTNSKNQ-- 515

  Fly   565 SQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPAN 629
                       .::||.|:.                                        |...:
plant   516 -----------TASPSSATL----------------------------------------DQYGD 529

  Fly   630 HNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDK 694
            .:.||:...           :.:|..:|..::::::|||.::..|...|..|.:...:.:.|.:.
plant   530 GHFRRIASN-----------VSAYVNMVSDTLRNTIPKACVYCQVRQAKLALLNYFYSQISKREG 583

  Fly   695 AE--TLLNESDHIAVRRKEAADMLKALTRANHIISEI 729
            .:  .||:|...:..||.|.|..|:...:|...|..:
plant   584 KQLGQLLDEDPALMDRRLECAKRLELYKKARDEIDAV 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	145/287 (51%)
		CrfC	88..728	CDD:223771	181/650 (28%)
		Dynamin_M	226..507	CDD:279383	67/288 (23%)
		GED	643..729	CDD:280391	19/87 (22%)
DL1E	NP_567094.1	DLP_1	40..306	CDD:206738	145/280 (52%)
		Dynamin_M	228..493	CDD:395818	65/275 (24%)
		GED	531..620	CDD:396682	21/99 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264244at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.780