DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and Dnm1l

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001346936.1	Gene:	Dnm1l / 74006	MGIID:	1921256	Length:	755	Species:	Mus musculus

Alignment Length:	781	Identity:	493/781 - (63%)
Similarity:	595/781 - (76%)	Gaps:	72/781 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            |||||||||||||||||||:|.||||||||:|:||||||||:||:|||..||||||:||||||:|
Mouse     1 MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLIL 65

  Fly    66 QLIY-SPLDDRENRSAENGT------------------SNAEEWGRFLHTK-KCFTDFDEIRKEI 110
            ||:: ||.|.|:....|||.                  ..|||||:||||| |.:|||||||:||
Mouse    66 QLVHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEI 130

  Fly   111 ENETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIEN 175
            ||||||.:|:|||:.||||:||:||.:|||||||||||:|||||||||:|||.||:||:|::|.|
Mouse   131 ENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISN 195

  Fly   176 PNSIILAVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGI 240
            ||||||||||||||||||||||::::|||||||||||:||||||||||||:|:|.||||||||||
Mouse   196 PNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGI 260

  Fly   241 IGVMNRSQKDIMDQKHIDDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKT 305
            |||:||||.||.::|.:.|.::||.||||:|||:||.||||.|||:|||||||||||||||:|||
Mouse   261 IGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKT 325

  Fly   306 RVNIMATQFQSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFH 370
            |:|::|.|:|||||||||.|.|||.||||:||||::.||.||||||:.|||:|||||||:.||||
Mouse   326 RINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFH 390

  Fly   371 ETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIH 435
            |||||||:|:.||.||:.:|||||||||||||||||||||||||||||||:||||||||||||:|
Mouse   391 ETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVH 455

  Fly   436 EEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDF 500
            ||||||:|||.|...||:|||||||:.||:|||.|||:|||.||.||.|:|||||||||||||||
Mouse   456 EEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDF 520

  Fly   501 HKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQ----------PQQQQPP 555
            .....|:.:            |:.::|    ||.::.::.  ||||:.          |..|:||
Mouse   521 ADACGLMNN------------NIEEQR----RNRLARELP--SAGSRDKSSKVPSALAPASQEPP 567

  Fly   556 QPNSSQQQYSQVHEQNHVAENSTPS------------MASTWLSNILPPAPTRPDSIENSTNNTP 608
             |.:|.:...::.:.|.....:.||            ....|...:   ..::.:.:.....:.|
Mouse   568 -PAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGML---KTSKAEELLAEEKSKP 628

  Fly   609 VHNNIVSPVK--PVNLLPDVPANHNP--RRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAI 669
            :.....||.|  .|||| |||.   |  |:|:.:||:||:|||.||||||.||||:||||||||:
Mouse   629 IPIMPASPQKGHAVNLL-DVPV---PVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAV 689

  Fly   670 MHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEIRETHM 734
            ||||||:|||.||||||..||||...:.||.||:.:|.||||||||||||..|:.||:||||||:
Mouse   690 MHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHL 754

  Fly   735 W 735
            |
Mouse   755 W 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	211/297 (71%)
		CrfC	88..728	CDD:223771	421/666 (63%)
		Dynamin_M	226..507	CDD:279383	212/280 (76%)
		GED	643..729	CDD:280391	61/85 (72%)
Dnm1l	NP_001346936.1	DLP_1	23..321	CDD:206738	211/297 (71%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	32..39		5/6 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	58..60		1/1 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	165..168		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	234..237		2/2 (100%)
		Dynamin_M	245..528	CDD:307257	214/282 (76%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	264..267		1/2 (50%)
		Middle domain. /evidence=ECO:0000250\|UniProtKB:O00429	363..508		114/144 (79%)
		Interaction with GSK3B. /evidence=ECO:0000250\|UniProtKB:O00429	467..704		110/262 (42%)
		B domain. /evidence=ECO:0000250\|UniProtKB:O00429	521..588		16/85 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..573		10/34 (29%)
		C-terminal dimerization domain. /evidence=ECO:0000250	561..755		94/201 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..607		2/21 (10%)
		GED	661..749	CDD:308047	62/87 (71%)
		Important for homodimerization. /evidence=ECO:0000250\|UniProtKB:O00429	673..687		11/13 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	437	1.000	Domainoid score	I558
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6384
Inparanoid	1	1.050	918	1.000	Inparanoid score	I358
Isobase	1	0.950	-	0	Normalized mean entropy	S470
OMA	1	1.010	-	-		QHG53558
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		oto94252
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2093
SonicParanoid	1	1.000	-	-		X2114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820