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Protein Alignment Drp1 and Mfn1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_077162.2	Gene:	Mfn1 / 67414	MGIID:	1914664	Length:	741	Species:	Mus musculus

Alignment Length:	791	Identity:	136/791 - (17%)
Similarity:	253/791 - (31%)	Gaps:	263/791 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWG 91
            ::...|..||||||||.:::....||.|.|..|.       .:..::..:...|...|..::|
Mouse    77 KVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTN-------CFLSVEGTDGDKAYLMTEGSDE-- 132

  Fly    92 RFLHTKKCFTDFDEIRKEIENETERAAGSNKGICPEPINLKIFSTHVV-----------NLTLVD 145
                 ||.....:::...:..:.:..||     |         ..||.           :|.|||
Mouse   133 -----KKSVKTVNQLAHALHMDKDLKAG-----C---------LVHVFWPKAKCALLRDDLVLVD 178

  Fly   146 LPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATSEAL------KLAKDVDP 204
            .||          .|:..::...:.|:..:.:..:|...:.:|.|.|.:..      :|:|   |
Mouse   179 SPG----------TDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSK---P 230

  Fly   205 D----GRRTLAVVTKLDLMDAGTDAIDI------LCGRVIPVKLGIIG---VMNR----SQKDIM 252
            :    ..|..|..::.:.|:      |:      .|...:..:|.::.   ..||    |.|:::
Mouse   231 NIFILNNRWDASASEPEYME------DVRRQHMERCLHFLVEELKVVSPSEARNRIFFVSAKEVL 289

  Fly   253 DQKHIDDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSL 317
            :               .||:.......|...||:.....|.                   :||:.
Mouse   290 N---------------SRKHKAQGMPEGGGALAEGFQARLQ-------------------EFQNF 320

  Fly   318 LNSYGEDVSDKSQTLLQIITKFSSAYCCTIEG-----TARNI-ETTELCGGARMGYIFHETFGR- 375
            ..::.|.:|..:     :.|||...   ||..     |.:|| ::..:....:..|...|...:
Mouse   321 EQTFEECISQSA-----VKTKFEQH---TIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQI 377

  Fly   376 -TLDSIHPLAGLSKMDILTAIRNATGP--------------RPALFVPEVSFELLVKRQIRRLEE 425
             .||.|.....|..:|:...|:..|..              |.::.|.|...|......:.::.:
Mouse   378 DRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYK 442

  Fly   426 PSLRCVELIHEEMQR-IVQHCGNEVQQEMLRFPKLHEKIVDVVTQLL----RRRLPHTNVMVENI 485
            ..|.  :.|.:.|.| :...|.|||...:|   :..::|::.:..||    :.:| ||.:..:.
Mouse   443 SELN--KHIEDGMGRNLADRCTNEVNASIL---QSQQEIIENLKPLLPAGIQNKL-HTLIPCKK- 500

  Fly   486 VAIELAYINTKH---PDFHKD---------AALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQ 538
              .:|:|....|   .||.:|         ::||...|.:.:.....:.|.:.....||
Mouse   501 --FDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPR------ 557

  Fly   539 ISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENS 603
                                                     |:|||      |.||:.|.:.:|:
Mouse   558 -----------------------------------------SLAST------PTAPSNPAAPDNA 575

  Fly   604 TNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLI-----------------K 651
            .....:          :.|:..:.:      ||.:......|:..:|                 .
Mouse   576 AQEELM----------ITLITGLAS------LTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGA 624

  Fly   652 SYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQ------SELVTHLYKSDKAETLLNESDHIAVRRK 710
            .|.|........:..:|.....|||..:.||      |...:|..:.:.|.|.......:.|.:|
Mouse   625 LYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVSFTSANCSHQVQQEMATTFARLCQQVDVTQK 689

  Fly   711 EAADMLKALTR 721
            ...:.:..|::
Mouse   690 HLEEEIARLSK 700

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.