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Protein Alignment Drp1 and Mfn2

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_570964.4	Gene:	Mfn2 / 64476	RGDID:	628843	Length:	757	Species:	Rattus norvegicus

Alignment Length:	679	Identity:	119/679 - (17%)
Similarity:	220/679 - (32%)	Gaps:	264/679 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWG 91
            ::...|..|:|||:||.:::....||.|.|..|.       .:..:...:...|...|..:||
  Rat    98 KVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTN-------CFLRVGGTDGHEAFLLTEGSEE-- 153

  Fly    92 RFLHTKKCFTDFDEIRKEIENETERAAGSNKGI------CPEPINLKIFSTHVVNLTLVDLPGIT 150
                 ||.....:::...:..:.:..|||...:      ||   .||      .:|.|:|.|||
  Rat   154 -----KKSVKTVNQLAHALHQDEQLHAGSLVSVMWPNSKCP---LLK------DDLVLMDSPGI- 203

  Fly   151 KVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMAT--------SEALKL--------- 198
                     |:..::...:.|:..:.:..:|...:.:|.|.|        ||.|..
  Rat   204 ---------DVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNR 259

  Fly   199 --AKDVDPD----------GRRTLAVVTKLDLMD---AG-----TDAIDILCGRV-----IPVKL 238
              |...:|:          .|.|..:|.:|.::|   ||     ..|.::|..||     :|...
  Rat   260 WDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRAQAGDRIFFVSAKEVLSARVQKAQGMPEGG 324

  Fly   239 GII-------------------------GVMNRSQKD-------------IMDQKHI-------- 257
            |.:                         .|..:.::.             |||..||
  Rat   325 GALAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVY 389

  Fly   258 ----DDQMKDEAAFLQRKYPTLA--------------TRNGTPYLAKTLNRL------------- 291
                .::.:|...|:.::...||              .|..:..:|:.:.||
  Rat   390 CLEMREERQDRLRFIDKQLELLAQDYKLRIKQMTEEVERQVSTAMAEEIRRLSVLVDEYQMDFHP 454

  Fly   292 -----------LMHHIRDCLPDLKTRVNIMATQFQSLLNSYGEDVSDKSQTLLQIITK------- 338
                       |..||.:.|.  :...:..:|...|.|.:..:|:.|..:.||.:..:
  Rat   455 SPVVLKVYKNELHRHIEEGLG--RNMSDRCSTAIASSLQTMQQDMIDGLKPLLPVSVRNQIDMLV 517

  Fly   339 ----FSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTL-------------------DSI 380
                ||.:|         ::...:||...:....||.:.|.|:                   |.:
  Rat   518 PRQCFSLSY---------DLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRALLGYNDQV 573

  Fly   381 H---------------PLAGLSKMDILTAI---------RNATGPRPALFVPEVSFELLVKRQI- 420
            .               |...|::.:::.::         |.:.|   .|.|..|.::.:..|.|
  Rat   574 QRPLPLTPANPSMPPLPQGSLTQEELMVSMVTGLASLTSRTSMG---ILVVGGVVWKAVGWRLIA 635

  Fly   421 ------------------RRLEEPSLR--CVELIHEEMQRIVQH----CGNEVQQEML-RFPKLH 460
                              .|.:|.:.:  .||...|::|.|:.:    |.::||||:. .|..|.
  Rat   636 LSFGLYGLLYVYERLTWTTRAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLC 700

  Fly   461 EKIVDVVTQLLRRRLPHTNVMVENIVAIE 489
            :: ||:....|.:.:...|..||.:.:::
  Rat   701 QQ-VDITRDNLEQEIAAMNKKVEALDSLQ 728

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.