Protein Alignment Drp1 and mfn2

DIOPT Version :9

• Sequence 1: NP_001259946.1
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001121726.1
• Gene: mfn2 / 567448
• ZFINID: ZDB-GENE-081105-44
• Length: 757
• Species: Danio rerio
• Alignment Length: 642
• Identity: 110/642 - (17%)
• Similarity: 221/642 - (34%)
• Gaps: 208/642 - (32%)

  Fly    27 QIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWG 91
            ::|..|..|:||||||.:::....||.|.|..|...|.::                ||...|.
Zfish    98 KVVFFGRTSNGKSSVINAMLWDKVLPSGIGHTTNCFLRVE----------------GTDGNES-- 144

  Fly    92 RFLHT-----KKCFTDFDEIRKEIENETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITK 151
             ||.|     :|.....:::...:..:.:..|||...:........:...   :|.|||.|||
Zfish   145 -FLLTEGSDERKSVKTVNQLAHALHQDEDLDAGSLVCVMWPKAKCALLRD---DLVLVDSPGI-- 203

  Fly   152 VPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATSEAL--KLAKDVDPDGRRTLAVVT 214
                    |:..::...:.|:..:.:..:|...:.:|.|.|.::.  |:.:.:..         .
Zfish   204 --------DVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKSFFHKVNERLSS---------P 251

  Fly   215 KLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQ---KHID---DQMKDEAAFLQRKYP 273
            .:.:::...||                   :.::.:.|::   :|:|   ..:.||...:.|.:.
Zfish   252 NIFILNNRWDA-------------------SANEPEYMEEVRRQHMDRCTSFLVDELRVVDRSHA 297

  Fly   274 TLATRNGTPYLAKTLNRLLMHHIRDC--LPD----LKTRVNIMATQFQSLLNSYGEDVSDKSQTL 332
                  |......:...:|...::..  :|:    |.........:||:....:.|.:|..:
Zfish   298 ------GDRIFFVSAKEVLQARVQKAQGMPEAGGALAEGFQARMFEFQNFERRFEECISQSA--- 353

  Fly   333 LQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHPLAGLSKMDILTAIRN 397
              :.|||.       :.|.|..:.:|   ..|:          .:||:|..|...::..|
Zfish   354 --VKTKFE-------QHTTRAKQISE---ALRL----------IMDSVHIAAQEQRIHCL----- 391

  Fly   398 ATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEK 462
                           |:..:|:.|         :|.|.:::..:...|.::::       |:.|:
Zfish   392 ---------------EMKEEREDR---------LEFIDKQLDLLTLDCKSKIK-------KITEE 425

  Fly   463 IVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLKTDSDPYSQINLGQRR 527
            :...|:..:...:....|:|::.           |.||| .:.:|..:.|.:...:.:..||:
Zfish   426 VEKQVSNAMAEEIRRLAVLVDDF-----------HMDFH-PSPVVLKVYKNELHRHIEEGLGR-- 476

  Fly   528 ANTPRNHMSPQISSHSAGSQQPQQQ------QPPQPNSSQQQYSQV---------HEQN------ 571
                  :||.:.||....:.|..|.      :|..|.:.::|..::         ::.|
Zfish   477 ------NMSERCSSAITVALQTTQTDMIDGLKPLLPITIREQVDKMVPRQCFALSYDLNCDKLCS 535

  Fly   572 --------HVAENSTPSMASTWLSN-ILPPAPTR------PDSIENSTNNTPVHNNI 613
                    |.      |:..|.|.| .|.|..||      .|.:..|...|||..::
Zfish   536 DFQEDIGFHF------SLGWTMLVNRFLGPKNTRRALMGYNDQVPRSLAITPVSTSM 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	49/288 (17%)
		CrfC	88..728	CDD:223771	93/581 (16%)
		Dynamin_M	226..507	CDD:279383	41/292 (14%)
		GED	643..729	CDD:280391
mfn2	NP_001121726.1	DLP_2	97..349	CDD:206739	54/316 (17%)
		Fzo_mitofusin	594..754	CDD:282633

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900