DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and si:dkey-32e23.4

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_005167422.1	Gene:	si:dkey-32e23.4 / 566871	ZFINID:	ZDB-GENE-081105-41	Length:	671	Species:	Danio rerio

Alignment Length:	748	Identity:	448/748 - (59%)
Similarity:	548/748 - (73%)	Gaps:	90/748 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            ||.|||:||:||:||.|||::.||||||||:||||||||||:||:|||.|||||:||||||||||
Zfish     1 METLIPIINRLQEVFLTVGAEIIQLPQIVVVGSQSSGKSSVLESLVGRDFLPRGSGIVTRRPLVL 65

  Fly    66 QLI-YSPLDDRE-----NRSAENGTSN-----AEEWGRFLHTK-KCFTDFDEIRKEIENETERAA 118
            ||: ..||::|.     |.|.:|..:|     |||||.|||.| :.||||:|||||||.||:|:.
Zfish    66 QLVNVPPLEERRKQDNGNGSKQNSQNNYPGIKAEEWGTFLHCKNQIFTDFNEIRKEIEEETDRST 130

  Fly   119 GSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAV 183
             :||||..|||.|||:|.:|::||||||||||||||||||||||.|::|::|.||.||||:||.|
Zfish   131 -NNKGISKEPIYLKIYSPNVLSLTLVDLPGITKVPVGDQPEDIEIQVQEMILSYISNPNSLILCV 194

  Fly   184 TAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQ 248
            :.||:|:|||:|||||::||.||||||.||:|||||||||||:::|.||||||:||||||:||||
Zfish   195 SPANSDLATSDALKLAREVDADGRRTLLVVSKLDLMDAGTDALEVLLGRVIPVRLGIIGVVNRSQ 259

  Fly   249 KDIMDQKHIDDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQ 313
            .|:..||.:.|..:||.|||||.||:||:|.|:.|||:||:||||||||||||:|||||.::..|
Zfish   260 HDLNTQKSLSDSCRDEQAFLQRHYPSLASRCGSRYLARTLSRLLMHHIRDCLPELKTRVTVLTAQ 324

  Fly   314 FQSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLD 378
            :||.|||||:.|.|.|.|||||:|||::.||.|||||||:|:|:||||||||.|||||||||||.
Zfish   325 YQSRLNSYGQPVEDHSATLLQIVTKFATDYCSTIEGTARHIQTSELCGGARMCYIFHETFGRTLQ 389

  Fly   379 SIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQ 443
            ||.||.||:::||||||||||||||||||||||||||||:||:||||||||||||:|||:|||:|
Zfish   390 SIDPLGGLTELDILTAIRNATGPRPALFVPEVSFELLVKKQIKRLEEPSLRCVELVHEELQRIIQ 454

  Fly   444 HCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVP 508
            ||.:...||:|||||||:.||:|||.|||:|||.||.||.|:||||||||||||||| .|||.|.
Zfish   455 HCSSYSTQELLRFPKLHDSIVEVVTGLLRKRLPITNEMVHNLVAIELAYINTKHPDF-TDAAQVS 518

  Fly   509 SLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHV 573
            :  ..:|......:.|:|..|                .:.|.:::.|.|...
Zfish   519 A--SVNSQQAEAGDGGKRWKN----------------EKMPSEEKGPMPGFG------------- 552

  Fly   574 AENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPD-VPANHNPRRLTD 637
                                                     ||.|.:|||.. ||.:   |:|:.
Zfish   553 -----------------------------------------SPSKAINLLDTAVPVS---RKLSS 573

  Fly   638 KEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNES 702
            :||:||:||:.|||.||.||||||||||||.:||||||:||::||||||..|||....:.||.||
Zfish   574 REQRDCEVIQRLIKCYFLIVRKSIQDSVPKTVMHFLVNFVKEHLQSELVGQLYKQPLLQELLIES 638

  Fly   703 DHIAVRRKEAADMLKALTRANHIISEIRETHMW 735
            ...|.:|.|.|.||:||.:|::|||||||||:|
Zfish   639 QETAQQRTEVAHMLEALKKASNIISEIRETHLW 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	197/289 (68%)
		CrfC	88..728	CDD:223771	378/641 (59%)
		Dynamin_M	226..507	CDD:279383	205/280 (73%)
		GED	643..729	CDD:280391	53/85 (62%)
si:dkey-32e23.4	XP_005167422.1	DLP_1	23..312	CDD:206738	197/289 (68%)
		Dynamin_M	236..516	CDD:307257	205/280 (73%)
		GED	577..665	CDD:308047	54/87 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586796
Domainoid	1	1.000	430	1.000	Domainoid score	I573
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	900	1.000	Inparanoid score	I365
OMA	1	1.010	-	-		QHG53558
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		otm25670
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2093
SonicParanoid	1	1.000	-	-		X2114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940