DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and mxh

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_009296275.1	Gene:	mxh / 562203	ZFINID:	ZDB-GENE-131126-68	Length:	644	Species:	Danio rerio

Alignment Length:	759	Identity:	198/759 - (26%)
Similarity:	322/759 - (42%)	Gaps:	188/759 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PVINKLQDVFNTVGSD-SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIY 69
            |.|..: |....:|.: .:.||.|.|:|.||||||||:|::.|.: ||||:|||||.||.|:|
Zfish    34 PYIEMI-DFMRRIGIERELALPAIAVVGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLELKL-- 94

  Fly    70 SPLDDRENRSAENGTSNAEEWGRFLHTKKCFTDFDEIRK------EIENETERA----AGSNKGI 124
                    |...:|:.    |...:       .::::|:      ::|:...:|    ||...||
Zfish    95 --------RKMSSGSG----WTAVI-------SYNDVRETFHEPAQVESFVRKAQNMLAGDGVGI 140

  Fly   125 CPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTD 189
            |.:.|:|:|.|..|.:|||:||||||:|||..|||||..||:.|:||:|....:|.|.|...|.|
Zfish   141 CDDLISLEITSPDVCDLTLIDLPGITRVPVKGQPEDIGDQIRRLILKFIAKKETINLVVVPCNVD 205

  Fly   190 MATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDA--IDILCGRVIPVKLGIIGVMNRSQKDIM 252
            :||:|||::|:.|||||.||||::||.||:|.|.:|  :.:|.|:|:|:|.|...|..|.|.||.
Zfish   206 IATTEALRMAQGVDPDGSRTLAILTKPDLVDKGAEADILQVLQGKVVPLKKGYTIVRCRGQSDIN 270

  Fly   253 DQKHIDDQMKDEAAFLQR----KYPTLATRNGTPYLAKTLNRLLMHHIRDC-LPDLKTRVNIMAT 312
            :...:.:..:.|..|...    .|.....|..|..|:..|.:.|:.||:.. ||.|:.:::|..:
Zfish   271 ENVSLSEATRQEKEFFSNHPHFSYLLEEQRATTSCLSTRLTKELVEHIKAASLPSLRDQIHINLS 335

  Fly   313 QFQSLLNSYGE----DVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETF 373
            ..:..|.||.:    :.......|.:.|.:||.             :.:|||   |.|.  .||
Zfish   336 AVRIELRSYADGPPLETERMGPYLSKKILEFSD-------------QISELC---RTGE--SET- 381

  Fly   374 GRTLDSIHPL-------AGLSKMDILTAIRNAT--------GPRPALFVPEVSFELLVKRQIRRL 423
            |.....:.|:       ...||.....:::..|        |.....|.....:|.:|||.:..|
Zfish   382 GNLYSLLRPVFKQWECHLSNSKALFRESVKEMTENYDEGHRGRELVTFSDYCVYESMVKRHVGDL 446

  Fly   424 EEPSLRCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAI 488
            ::|::..::||    :.|||                  |...|:.:|.....||...:::|
Zfish   447 KQPAMETLKLI----RGIVQ------------------KEFRVMCELCFPNYPHLRHIIQN---- 485

  Fly   489 ELAYINTKHPDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQ 553
            .:..|::|...            |.:...:..||: ::...|.....:.:|.......:
Zfish   486 HIDEIHSKQES------------KVEKRIHEYINM-EKLVYTQDPIFTQKIVDFKFVEK------ 531

  Fly   554 PPQPNSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVK 618
                   :|:|..|                               :::...:.|..||..|...:
Zfish   532 -------RQEYESV-------------------------------TLDTGEDATSPHNCAVFDTR 558

  Fly   619 PVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQS 683
              ||.||                      .|| .|:.||.:.:.|.:|..|:.|::......|::
Zfish   559 --NLTPD----------------------KLI-IYYEIVYQRLADYIPMVILLFMLKEAAVMLRA 598

  Fly   684 ELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIIS 727
            :.:.....:|..:.|:.:|: ...:|.|....::.|..|...||
Zfish   599 QAMDLREGADVVKLLMEDSE-AGQKRSELHQRMERLRLAQERIS 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	115/294 (39%)
		CrfC	88..728	CDD:223771	164/676 (24%)
		Dynamin_M	226..507	CDD:279383	65/304 (21%)
		GED	643..729	CDD:280391	19/85 (22%)
mxh	XP_009296275.1	DLP_1	51..324	CDD:206738	115/294 (39%)
		Dynamin_M	244..519	CDD:279383	69/332 (21%)
		GED	568..641	CDD:295362	15/73 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010