DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drp1 and dnm2a

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_021326548.1	Gene:	dnm2a / 559334	ZFINID:	ZDB-GENE-050913-84	Length:	885	Species:	Danio rerio

Alignment Length:	799	Identity:	297/799 - (37%)
Similarity:	439/799 - (54%)	Gaps:	112/799 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||:||||||.|:::| |.::.||||.|:|.||:|||||:|:.|||.|||||:||||||||:
Zfish     6 MEELIPLINKLQDAFSSIGQSCNLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLI 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            |||:                :|..|:..|||.| :.|.||||:|:|||.||:|..||||||.|.|
Zfish    71 LQLV----------------NNKAEYAEFLHCKGRKFVDFDEVRQEIEAETDRITGSNKGISPIP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.:|:||||:||||:|||.|||||.|||.||:::::::|...:.:|||||.||.|:|.|
Zfish   120 INLRVYSPNVLNLTLIDLPGMTKVAVGDQPPDIEHQIRDMIMQFITRESCLILAVTPANMDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :|||:||:|||.|.||:.|:|||||||.||||.|||..:::|::.|.|||:|||||||..:|.|.
Zfish   185 DALKVAKEVDPQGLRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIDGRKDIR 249

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..:..|..|.  ...|..:|.|.|||:|.|.||:.|.:||||.||.|::::.......:..:..|
Zfish   250 AALAAERKFFLSHPSYRHMAERMGTPHLQKALNQQLTNHIRDTLPGLRSKLQSQLLSLEKEVEEY 314

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .:|.:.|::.|||::.:|...:...|||:...::|.||.||||:..||||.|...|..|..
Zfish   315 KNFRPDDPTRKTKALLQMVQQFGVDFEKCIEGSGDQVDTAELSGGARINRIFHERFPFELVKIVF 379

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            .....:.:|..||:|..|.|..||.|:::||.:||:||.:|:||.|:|::|:.:|:....:.|.|
Zfish   380 DEKELRREISHAIKNVHGVRTGLFTPDLAFEAIVKKQIIKLKEPCLKCIDLVIQELINTFRQCTN 444

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDF---------HKD 503
            ::..    :|:|.|:...:||..:|.|...|...|..::..||:||||.|.||         ..|
Zfish   445 KLSS----YPRLREETERIVTTYVREREGKTKDQVLLLIDTELSYINTNHEDFIGFANLDLRRLD 505

  Fly   504 AALVPSLLKTDSDPYSQIN--------LGQRRANTP-----RNHMSPQISSHSAGS--------- 546
            ...:|......:...:.:|        ||..|....     :..::..||....||
Zfish   506 DGTIPGYSNNSAQQRNIVNKKRAIPNQLGGLREGEAEKVIRKGWLTLNISIMKGGSKEYWFVLTA 570

  Fly   547 --------QQPQQQQPPQP-----------------------NSSQQQYSQVHEQNHVAENSTPS 580
                    ::.::::...|                       |:.|:...:...|..:|.:|...
Zfish   571 ESLSWYKDEEEKEKKYMLPLDNLKLRDVEKGFMSTKHIFAIFNTEQRNVYKDLRQIELACDSQED 635

  Fly   581 MASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDV 645
            |.| |.::.| .|...|:..:       |.:...:|....::.|.:             ::..:.
Zfish   636 MDS-WKASFL-RAGVYPEKDQ-------VESEEAAPADSFSMDPQL-------------ERQVET 678

  Fly   646 IEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRK 710
            |.:|:.||..||.|:|:|.:||.|||.::|..||.:.|||:.:||.|....:|:.||...|.||.
Zfish   679 IRNLVDSYIGIVNKTIRDLMPKTIMHLMINSAKDFIHSELLAYLYSSGDQNSLMEESADQAQRRD 743

  Fly   711 EAADMLKALTRANHIISEI 729
            |...|..|:..|..||.:|
Zfish   744 EMLRMYHAIKEALSIIGDI 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	153/280 (55%)
		CrfC	88..728	CDD:223771	248/708 (35%)
		Dynamin_M	226..507	CDD:279383	104/295 (35%)
		GED	643..729	CDD:280391	35/85 (41%)
dnm2a	XP_021326548.1	DYNc	6..245	CDD:197491	148/254 (58%)
		Dynamin_M	216..498	CDD:307257	104/285 (36%)
		PH_dynamin	544..652	CDD:269958	16/109 (15%)
		GED	674..762	CDD:308047	35/87 (40%)
		Atrophin-1	<764..882	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720