DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drp1 and dnm3a

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_009292874.1	Gene:	dnm3a / 557996	ZFINID:	ZDB-GENE-040724-76	Length:	835	Species:	Danio rerio

Alignment Length:	790	Identity:	301/790 - (38%)
Similarity:	438/790 - (55%)	Gaps:	105/790 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSD-SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|:|||.|:.:|.: .:.||||.|:|.||:|||||:|:.|||.|||||:|||||||||
Zfish     6 MEELIPLVNRLQDAFSAIGQNCDLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            ||||                |:|.|...|||.| |.|||||::|:|||.||:|..|:||||...|
Zfish    71 LQLI----------------SSASEHAEFLHCKGKKFTDFDDVRREIEAETDRVTGTNKGISSIP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||::||.:|:||||:||||||||||||||.|||.||:::::::|...|.:|||||.||.|:|.|
Zfish   120 INLRVFSPNVLNLTLIDLPGITKVPVGDQPADIEYQIRDMIMQFICKENCLILAVTPANMDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :||||||||||.|.||:.|:|||||:|.|||..|:|..|::|::.|.|||:|||||||..:|.|.
Zfish   185 DALKLAKDVDPQGHRTIGVITKLDLVDKGTDVRDVLENRLLPLRRGYIGVVNRSQKDIEGKKDIS 249

  Fly   259 DQMKDEAAFLQR--KYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..:..|..|.:.  .|..:|...|||||.:.||:.|.:||||.||.|::|:.............|
Zfish   250 AALAAEKRFFKSHPAYRHMADYMGTPYLQRLLNQQLTNHIRDTLPALRSRLQAQLLSLDKEAEEY 314

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .:|.|.|::.|:|:|..|...:...|||:...::|.:|.|||::..||||.|...|..:..
Zfish   315 KGLNPDDPSRKTKALMQLIQHFGLDFEKRIEGSGDQVDTVQLSGGAKINRIFHERFPFELVKMEF 379

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            .....:.:|..||:|..|.|..||.|:::||.:||:||.:|:.|.|:||:::.:|:...||.|.|
Zfish   380 DEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPCLKCVDMVIQELINTVQQCTN 444

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLK 512
            :::.    ||||.|:...:||..:|.|...|...|...:.|:|:||||.|.||
Zfish   445 KLES----FPKLREETERIVTTHIRERESQTKDQVLLSLEIQLSYINTNHEDF------------ 493

  Fly   513 TDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAENS 577
                      :|...|....:.:|.:.|:.:.|:..|    ||.....::.:..::..:.:...|
Zfish   494 ----------IGFANAQQKTSQLSNKPSAGNQGAAPP----PPSQIVIRKGWVIINNISLIKGGS 544

  Fly   578 ------TPSMASTWLSN--------ILPPAPTRPDSIENS---------TNNTPVHNNIVSPVKP 619
                  ..:.:.:|..:        :||....:...||.|         ..||. ..|:....:.
Zfish   545 KEYWFVLTAESLSWFKDDEEKEKKYMLPLDNLKVRDIEKSFMSSKHVFAIFNTE-QRNVYKDYRH 608

  Fly   620 VNLLPD------------VPANHNPRRLT--------------DKE-QKDCDVIEHLIKSYFYIV 657
            :.|..|            :.|...|.:.|              |.: ::..:.|.:|:.||..||
Zfish   609 LELACDTQDDVDSWKASLLRAGVYPEKTTADGDGSSQTESFSMDPQLERQVETIRNLVDSYMSIV 673

  Fly   658 RKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRA 722
            .|||:|.:||.|||.::|.|::.:.|||:..||.|....:|::||...|:||:|......||..|
Zfish   674 YKSIRDLMPKTIMHLVINNVEEFIHSELLAQLYSSGDQYSLMDESPEQALRREEVLRTHAALKEA 738

  Fly   723 NHIISEIRET 732
            .:||::|..|
Zfish   739 LNIITDISTT 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	158/280 (56%)
		CrfC	88..728	CDD:223771	251/696 (36%)
		Dynamin_M	226..507	CDD:279383	104/286 (36%)
		GED	643..729	CDD:280391	35/85 (41%)
dnm3a	XP_009292874.1	DYNc	6..245	CDD:197491	151/254 (59%)
		CrfC	78..>502	CDD:223771	194/449 (43%)
		Dynamin_M	217..502	CDD:279383	106/310 (34%)
		PH_dynamin	526..635	CDD:269958	14/109 (13%)
		PH	526..629	CDD:278594	12/103 (12%)
		GED	657..740	CDD:280391	33/82 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720