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Protein Alignment Drp1 and MFN1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_284941.2	Gene:	MFN1 / 55669	HGNCID:	18262	Length:	741	Species:	Homo sapiens

Alignment Length:	634	Identity:	112/634 - (17%)
Similarity:	208/634 - (32%)	Gaps:	190/634 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWG 91
            ::...|..||||||||.:::....||.|.|.:|.       .:..::..:...|...|..::|
Human    77 KVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITN-------CFLSVEGTDGDKAYLMTEGSDE-- 132

  Fly    92 RFLHTKKCFTDFDEIRKEIENETERAAGSNKGICPEPINLKIFSTHVV------NLTLVDLPGIT 150
                 ||.....:::...:..:.:..||     |    .:::|.....      :|.|||.||
Human   133 -----KKSVKTVNQLAHALHMDKDLKAG-----C----LVRVFWPKAKCALLRDDLVLVDSPG-- 181

  Fly   151 KVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATSEAL------KLAKDVDPDGRRT 209
                    .|:..::...:.|:..:.:..:|...:.:|.|.|.:..      :|:|.
Human   182 --------TDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKP-------- 230

  Fly   210 LAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHIDDQMKDEAAFLQRKYPT 274
                                         .|..:.||......:.::::|..:..   ::|....
Human   231 -----------------------------NIFILNNRWDASASEPEYMEDVRRQH---MERCLHF 263

  Fly   275 LATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIM--------------ATQFQSLLNSYGEDV 325
            |..........:..||:.....::.|...|.:...|              ..:||:....:.|.:
Human   264 LVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECI 328

  Fly   326 SDKSQTLLQIITKFS--SAYCCTIEGTARNI-ETTELCGGARMGYIFHETFGR--TLDSIHPLAG 385
            |..:     :.|||.  :.....|..|.:|| ::..|....:..|...|...:  .||.|.....
Human   329 SQSA-----VKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMN 388

  Fly   386 LSKMDILTAIRNATGP--------------RPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHE 436
            |..:|:...|:..|..              |.::.|.|...|......:.::.:..|.  :.|.:
Human   389 LLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELN--KHIED 451

  Fly   437 EMQR-IVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLP---HTNVMVENIVAIELAYINTKH 497
            .|.| :...|.:||...:|   :..::|::.:..||...:.   ||.:..:.   .:|:|....|
Human   452 GMGRNLADRCTDEVNALVL---QTQQEIIENLKPLLPAGIQDKLHTLIPCKK---FDLSYNLNYH 510

  Fly   498 ---PDFHKDAALVPSLLKTDSDPYSQINLG----QRRANTPRNHMSPQISSHSAGSQQPQQQQPP 555
               .||.:|...             :.:||    ..|...|||.....:     |..:|..|.|
Human   511 KLCSDFQEDIVF-------------RFSLGWSSLVHRFLGPRNAQRVLL-----GLSEPIFQLP- 556

  Fly   556 QPNSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENST 604
                                   .|:|||      |.|||.|.:.:|::
Human   557 -----------------------RSLAST------PTAPTTPATPDNAS 576

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.