Protein Alignment Drp1 and OPA1

DIOPT Version :9

• Sequence 1: NP_001259946.1
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_570850.2
• Gene: OPA1 / 4976
• HGNCID: 8140
• Length: 1015
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 141/653 - (21%)
• Similarity: 248/653 - (37%)
• Gaps: 182/653 - (27%)

  Fly     2 EALIPVINKLQDV-------FNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTG-IV 58
            ::||.:.:::.||       :||    ...||::||:|.||:||:||:|.:......|||:| ::
Human   317 KSLIDMYSEVLDVLSDYDASYNT----QDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMM 377

  Fly    59 TRRPLVLQLIYSPLDDRENRSAENGTSNAEEWGRFLHTKKCFTDFDEIRKEIENETERAAGSNKG 123
            ||.|:.:.|...|     :..|....|:.|    |..||:  .|...:|.|||....:.......
Human   378 TRSPVKVTLSEGP-----HHVALFKDSSRE----FDLTKE--EDLAALRHEIELRMRKNVKEGCT 431

  Fly   124 ICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANT 188
            :.||.|:|.:....:..:.||||||:..........|.:..|..:...|::|||:|||.:...:.
Human   432 VSPETISLNVKGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSV 496

  Fly   189 DMATSEALKLAKDVDPDGRRTLAVVTKLDLMD---AGTDAI-DILCGRVIPVK-LGIIGVM---N 245
            |...|....|...:||.||||:.|:||:||.:   |....| .|:.|::.|:| ||...|:   .
Human   497 DAERSIVTDLVSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKG 561

  Fly   246 RSQKDIMDQKHIDDQMKDEAAFLQR---KYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRV 307
            .|.:.|...:..:::....:..|:.   |...:.|||            |...:.||
Human   562 NSSESIEAIREYEEEFFQNSKLLKTSMLKAHQVTTRN------------LSLAVSDC-------- 606

  Fly   308 NIMATQFQSLLNSYGEDVSDK-SQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHE 371
                  |..::....|..:|. ..|...:.|::.:.|     ...|.::..||         |.:
Human   607 ------FWKMVRESVEQQADSFKATRFNLETEWKNNY-----PRLRELDRNEL---------FEK 651

  Fly   372 TFGRTLDSIHPLAGLSKMDILTAIRNATGPRPA------LFVP---------------------- 408
            .....||.:..|:.::.......::.:...|.:      :::|
Human   652 AKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWT 716

  Fly   409 ---------EVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIV------QHCGNEVQQEMLRFPK 458
                     ||::|.|.:...|.:.||..:..:.|.::::..|      :|..|:..::.||..:
Human   717 DKQLPNKAVEVAWETLQEEFSRFMTEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRVIQ 781

  Fly   459 LHEKIVD--------------VVTQLLRRRLPHTNVMVENIVAIE-------------------- 489
             |..:.|              .:.:.|:.||..|...:||:|..:
Human   782 -HNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKRWLYWKNRTQEQCVHNE 845

  Fly   490 -------LAYINTKHPDF--------------HKDAALVPSLLKTDSDPYSQINLGQRR--ANTP 531
                   :...|.:||.:              .:...:.|||:|   |.:.|:   .||  ..|.
Human   846 TKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIK---DTWHQV---YRRHFLKTA 904

  Fly   532 RNH 534
            .||
Human   905 LNH 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	84/289 (29%)
		CrfC	88..728	CDD:223771	112/559 (20%)
		Dynamin_M	226..507	CDD:279383	58/387 (15%)
		GED	643..729	CDD:280391
OPA1	NP_570850.2	DLP_1	342..616	CDD:206738	85/310 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810