Protein Alignment Drp1 and dnm2

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_031753735.1
• Gene: dnm2 / 496487
• XenbaseID: XB-GENE-959257
• Length: 881
• Species: Xenopus tropicalis
• Alignment Length: 794
• Identity: 302/794 - (38%)
• Similarity: 443/794 - (55%)
• Gaps: 116/794 - (14%)

  Fly     1 MEALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|||||.|:::| :.::.||||.|:|.||:|||||:|:.|||.|||||:||||||||:
 Frog     6 MEELIPLVNKLQDAFSSIGQACNLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLI 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            ||||:|                ..|:..|||.| |.||||||:|:|||.||:|..|:||||.|.|
 Frog    71 LQLIFS----------------KTEYAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.:|:||||:||||||||||||||.|||.|||:::|::|...:.:|||||..|||:|.|
 Frog   120 INLRVYSPNVLNLTLIDLPGITKVPVGDQPHDIEYQIKDMILQFISRDSCLILAVTPGNTDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :|||:||:|||.|.||:.|:|||||||.||||.|||..:::|::.|.|||:|||||||..:|.|.
 Frog   185 DALKMAKEVDPQGLRTIGVITKLDLMDEGTDAKDILENKLLPLRRGYIGVVNRSQKDIDGKKDIK 249

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..:..|..|.  ...|..:|.|.|||:|.||||:.|.:|||:.||.|:.::.......:..:..|
 Frog   250 AALGAERKFFLSHPGYRHIAERMGTPHLQKTLNQQLTNHIRETLPALRNKLQSQLLSLEKEVEEY 314

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .:|.:.|::.|||::.:|...:...|||:...::|.||.||||:..||||.|        |
 Frog   315 KNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERF--------P 371

  Fly   383 LAGLSKM---------DILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEM 438
            .. |.||         :|..||:|..|.|..||.|:::||.:||:|:.:|:||.|:||:::.:|:
 Frog   372 FE-LVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQVVKLKEPCLKCVDMVIQEL 435

  Fly   439 QRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDF--H 501
            ...|:.|    ..::|.:|||.|:...:||..:|.|...|...:..::.|||:||||.|.||  .
 Frog   436 INTVRQC----TAKLLSYPKLREETERIVTTYIREREGKTKDQILLLIDIELSYINTNHEDFIGF 496

  Fly   502 KDAALVPSLLKTDSDPYSQIN-----------LGQRRANTPRNHMS---------------PQIS 540
            .:|.....::.......||:|           |..||.....|::|               ..:|
 Frog   497 ANAYYTEQIIPGAQQRSSQLNKKRAVPNQGEILVIRRGWLTINNISIMKGGSKEYWFILTAESLS 561

  Fly   541 SHSAGSQQPQQQQPPQPN-----------SSQQQYSQVH-EQNHVAEN--------STPSMASTW 585
            .:....::.::...|..|           |::..::..: ||.:|.::        .:.....:|
 Frog   562 WYKDEEEKEKKYMLPLDNLKIRDIEKGFMSTKHIFAIFNTEQRNVYKDLRQIELACDSQEDVDSW 626

  Fly   586 LSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLI 650
            .::.| .|...|:..:.....|                     ..|...:..:.::..:.|.:|:
 Frog   627 KASFL-RAGVYPEKDQREEEET---------------------QENTFSMDPQLERQVETIRNLV 669

  Fly   651 KSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADM 715
            .||..||.|||:|.:||.|||.::|..||.:.|||:.:||.|....:|:.||...|.||::...|
 Frog   670 DSYICIVNKSIRDLMPKTIMHLMINNSKDFIHSELLAYLYSSADQNSLMEESADQAQRREDMLRM 734

  Fly   716 LKALTRANHIISEI 729
            ..||..|..||.:|
 Frog   735 YHALKEALKIIGDI 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	159/280 (57%)
		Dynamin_M	224..507	CDD:460033	109/299 (36%)
		GED	639..729	CDD:460495	36/89 (40%)
dnm2	XP_031753735.1	DYNc	6..245	CDD:197491	152/254 (60%)
		Dynamin_M	215..499	CDD:460033	108/296 (36%)
		PH_dynamin	530..639	CDD:269958	15/109 (14%)
		GED	658..748	CDD:460495	36/89 (40%)
		PHA03247	<748..877	CDD:223021	1/1 (100%)